GB1060444A - A new antibiotic ussamycin - Google Patents

A new antibiotic ussamycin

Info

Publication number
GB1060444A
GB1060444A GB12376/64A GB1237664A GB1060444A GB 1060444 A GB1060444 A GB 1060444A GB 12376/64 A GB12376/64 A GB 12376/64A GB 1237664 A GB1237664 A GB 1237664A GB 1060444 A GB1060444 A GB 1060444A
Authority
GB
United Kingdom
Prior art keywords
ussamycin
water
acid
aqueous
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12376/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1060444A publication Critical patent/GB1060444A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/56—Streptomyces lavendulae

Abstract

The invention relates to an antibiotic ussamycin which is active against gram positive micro-organisms and tumours; is basic forming salts with inorganic and organic acids; soluble in methanol; insoluble in acetone, ether, benzene, chloroform and petroleum ether; hydrochloride is soluble in water; light-yellow colour, stable at pH 3 to 8; on acid hydrolysis produces glycine, alanine, leucine, serine, aspartic acid, glutamic acid, arginine and lysine; Rf value 0.74 in n-butanol, pyridine, acetic acid, water (15 : 10 : 3 : 12); no U.V. spectrum. Ussamycin is produced by cultivating streptomyces lavendulae NRRL 3119 (mutant) in an aqueous nutrient medium. It is isolated from the clarified broth by (A) adsorption on active carbon, activated earth or a weakly acidic ion exchanger. Elution is by means of aqueous acid or aqueous water-miscible organic solvents, e.g. aqueous methanol; (B) precipitation as picrate of Reineckate. Purification is by adsorption or distribution chromatography or by counter-current distribution between two immiscible solvent phases, e.g. in sec-butanol-3% acetic acid. The crude antibiotic may be dissolved in water and precipitated with Reinecke salt. Specified salts are the hydrochloride, sulphate, phosphate, nitrate, acetate, propionate, valerate, palmitate, oleate, succinate, citrate or mandelate. Pharmaceutical preparations for human or veterinary use comprise ussamycin or a physiologically tolerable salt thereof and a carrier. Formulations may be tablets, dragees, powders, solutions, suspensions, emulsions, suppositories and injections. The antibiotic may be added to an animal feed and may be used as a disinfectant or preservative.
GB12376/64A 1963-03-27 1964-03-24 A new antibiotic ussamycin Expired GB1060444A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH390663 1963-03-27
CH516263 1963-04-24

Publications (1)

Publication Number Publication Date
GB1060444A true GB1060444A (en) 1967-03-01

Family

ID=25694139

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12376/64A Expired GB1060444A (en) 1963-03-27 1964-03-24 A new antibiotic ussamycin

Country Status (6)

Country Link
BE (1) BE645730A (en)
DE (1) DE1208449B (en)
ES (1) ES298011A1 (en)
FR (1) FR3429M (en)
GB (1) GB1060444A (en)
NL (1) NL6403317A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221625A (en) * 1992-01-10 1993-06-22 Merck & Co., Inc. Cyclcic FR-900520 microbial biotransformation agent
US5268281A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268282A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5283183A (en) * 1992-09-28 1994-02-01 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5290689A (en) * 1992-09-28 1994-03-01 Merck & Co., Inc. New cyclic FR-900520 microbial biotransformation agent

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5937952B2 (en) * 1977-09-12 1984-09-12 正 新井 Antibiotic saframycin A, B, C, D, E and its manufacturing method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221625A (en) * 1992-01-10 1993-06-22 Merck & Co., Inc. Cyclcic FR-900520 microbial biotransformation agent
US5268281A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268282A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5283183A (en) * 1992-09-28 1994-02-01 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5290689A (en) * 1992-09-28 1994-03-01 Merck & Co., Inc. New cyclic FR-900520 microbial biotransformation agent

Also Published As

Publication number Publication date
FR3429M (en) 1965-07-12
NL6403317A (en) 1964-09-28
ES298011A1 (en) 1964-12-01
DE1208449B (en) 1966-01-05
BE645730A (en) 1964-09-28

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