ES2963814T3 - Polímeros de ácido nucleico modificados con fosforotioato quelados para usar en combinación con un inhibidor de la polimerasa del VHB para el tratamiento de infecciones por los virus de la hepatitis B y la hepatitis D - Google Patents
Polímeros de ácido nucleico modificados con fosforotioato quelados para usar en combinación con un inhibidor de la polimerasa del VHB para el tratamiento de infecciones por los virus de la hepatitis B y la hepatitis D Download PDFInfo
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- ES2963814T3 ES2963814T3 ES15818148T ES15818148T ES2963814T3 ES 2963814 T3 ES2963814 T3 ES 2963814T3 ES 15818148 T ES15818148 T ES 15818148T ES 15818148 T ES15818148 T ES 15818148T ES 2963814 T3 ES2963814 T3 ES 2963814T3
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A61K31/66—Phosphorus compounds
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
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- Biophysics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201462022846P | 2014-07-10 | 2014-07-10 | |
| US201462091943P | 2014-12-15 | 2014-12-15 | |
| PCT/CA2015/050626 WO2016004525A1 (en) | 2014-07-10 | 2015-07-07 | Methods for the treatment of hepatitis b and hepatitis d virus infections |
Publications (1)
| Publication Number | Publication Date |
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| ES2963814T3 true ES2963814T3 (es) | 2024-04-02 |
Family
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Family Applications (1)
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| ES15818148T Active ES2963814T3 (es) | 2014-07-10 | 2015-07-07 | Polímeros de ácido nucleico modificados con fosforotioato quelados para usar en combinación con un inhibidor de la polimerasa del VHB para el tratamiento de infecciones por los virus de la hepatitis B y la hepatitis D |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9603865B2 (https=) |
| EP (1) | EP3166615B1 (https=) |
| JP (2) | JP2017521433A (https=) |
| KR (2) | KR20170029577A (https=) |
| CN (2) | CN106659730A (https=) |
| AU (1) | AU2015286199B2 (https=) |
| BR (1) | BR112017000320B1 (https=) |
| CA (1) | CA2954182C (https=) |
| CL (1) | CL2017000008A1 (https=) |
| CU (1) | CU20170001A7 (https=) |
| CY (1) | CY1126361T1 (https=) |
| DK (1) | DK3166615T3 (https=) |
| DO (1) | DOP2017000002A (https=) |
| EA (1) | EA036745B1 (https=) |
| EC (1) | ECSP16097355A (https=) |
| ES (1) | ES2963814T3 (https=) |
| FI (1) | FI3166615T3 (https=) |
| HK (1) | HK1231402A1 (https=) |
| HR (1) | HRP20231400T1 (https=) |
| HU (1) | HUE064449T2 (https=) |
| IL (1) | IL249660B (https=) |
| LT (1) | LT3166615T (https=) |
| MD (1) | MD4760C8 (https=) |
| MX (1) | MX381042B (https=) |
| MY (1) | MY178087A (https=) |
| PH (1) | PH12017500010B1 (https=) |
| PL (1) | PL3166615T3 (https=) |
| PT (1) | PT3166615T (https=) |
| RS (1) | RS64833B1 (https=) |
| SG (1) | SG11201700073PA (https=) |
| SI (1) | SI3166615T1 (https=) |
| SM (1) | SMT202300380T1 (https=) |
| TW (1) | TWI766831B (https=) |
| WO (1) | WO2016004525A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20211783A1 (es) * | 2018-11-08 | 2021-09-08 | Aligos Therapeutics Inc | Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos |
| US11166976B2 (en) | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| WO2021119325A1 (en) * | 2019-12-12 | 2021-06-17 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| WO2021223398A1 (zh) * | 2020-05-07 | 2021-11-11 | 西安新通药物研究股份有限公司 | 治疗肝病的晶型及其应用 |
| CN113651852A (zh) * | 2020-05-07 | 2021-11-16 | 西安新通药物研究股份有限公司 | 甲磺酸帕拉德福韦e晶型及其应用 |
| CN114057816B (zh) * | 2020-07-30 | 2025-02-11 | 浙江柏拉阿图医药科技有限公司 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
| WO2022109129A1 (en) * | 2020-11-20 | 2022-05-27 | Aligos Therapeutics, Inc. | Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting |
| TW202245809A (zh) | 2020-12-18 | 2022-12-01 | 美商詹森藥物公司 | 用於治療b型肝炎病毒感染之組合療法 |
| WO2022152869A1 (en) | 2021-01-15 | 2022-07-21 | Janssen Sciences Ireland Unlimited Company | Use of oligonucleotides for individuals with hepatic impairment |
| WO2022261046A1 (en) * | 2021-06-07 | 2022-12-15 | Antios Therapeutics, Inc. | Compositions and methods of treating hepatitis d and hepatitis b/hepatitis d co-infections with phosphoramidate clevudine prodrugs |
| EP4367241A1 (en) | 2021-07-09 | 2024-05-15 | GlaxoSmithKline Intellectual Property (No.3) Limited | Use of oligonucleotides for individuals with renal impairment |
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| US5482836A (en) * | 1993-01-14 | 1996-01-09 | The Regents Of The University Of California | DNA purification by triplex-affinity capture and affinity capture electrophoresis |
| EP2330194A3 (en) | 2002-09-13 | 2011-10-12 | Replicor, Inc. | Non-sequence complementary antiviral oligonucleotides |
| WO2006091798A2 (en) * | 2005-02-22 | 2006-08-31 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vaccines and methods for prevention and treatment of drug-resistant hiv-1 and hepatitis b virus |
| BR112013003875B1 (pt) | 2010-08-20 | 2021-10-05 | Replicor Inc | Composições farmacêuticas compreendendo complexo de quelato de oligonucleotídeo, formulação de oligonucleotídeo, e usos |
| WO2012058210A1 (en) * | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| WO2012075114A2 (en) * | 2010-12-01 | 2012-06-07 | Ablitech, Inc. | Nucleic acid-polymer conjugates and uses thereof |
| AR091065A1 (es) * | 2012-05-18 | 2014-12-30 | Replicor Inc | Una formulacion farmaceutica que comprende un quelato de oligonucleotidos antiviral para el tratamiento de una infeccion antiviral |
| MY168778A (en) * | 2012-05-18 | 2018-12-04 | Replicor Inc | Oligonucleotide chelate complex-polypeptide compositions and methods |
| AU2013308045B2 (en) | 2012-08-30 | 2018-10-04 | Replicor Inc. | Methods for the treatment of hepatitis B and hepatitis D infections |
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2015
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- 2015-07-07 PT PT158181487T patent/PT3166615T/pt unknown
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- 2015-07-07 SI SI201531976T patent/SI3166615T1/sl unknown
- 2015-07-07 PH PH1/2017/500010A patent/PH12017500010B1/en unknown
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2016
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2017
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- 2017-01-03 CL CL2017000008A patent/CL2017000008A1/es unknown
- 2017-01-03 EC ECIEPI201697355A patent/ECSP16097355A/es unknown
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2020
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2023
- 2023-11-07 CY CY20231100626T patent/CY1126361T1/el unknown
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