ES2951648T3 - Inmunoglobulinas de unión a Tgfbeta1 y uso de las mismas - Google Patents
Inmunoglobulinas de unión a Tgfbeta1 y uso de las mismas Download PDFInfo
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- ES2951648T3 ES2951648T3 ES17716332T ES17716332T ES2951648T3 ES 2951648 T3 ES2951648 T3 ES 2951648T3 ES 17716332 T ES17716332 T ES 17716332T ES 17716332 T ES17716332 T ES 17716332T ES 2951648 T3 ES2951648 T3 ES 2951648T3
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Oncology (AREA)
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- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US201762452866P | 2017-01-31 | 2017-01-31 | |
| PCT/US2017/021972 WO2017156500A1 (en) | 2016-03-11 | 2017-03-10 | Tgfb1-binding immunoglobulins and use thereof |
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| EP3658583A1 (en) * | 2017-07-28 | 2020-06-03 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgf-beta 1 and uses thereof |
| EP3694552A1 (en) | 2017-10-10 | 2020-08-19 | Tilos Therapeutics, Inc. | Anti-lap antibodies and uses thereof |
| JP7315566B2 (ja) * | 2018-02-23 | 2023-07-26 | 中外製薬株式会社 | 種交差性抗潜在型ＴＧＦ－β１抗体および使用方法 |
| US20210340238A1 (en) | 2018-07-11 | 2021-11-04 | Scholar Rock, Inc. | TGFß1 INHIBITORS AND USE THEREOF |
| MA53125A (fr) | 2018-07-11 | 2021-05-19 | Scholar Rock Inc | Inhibiteurs de tgf?1 sélectifs selon l'isoforme à affinité élevée |
| RS62914B1 (sr) | 2018-07-11 | 2022-03-31 | Scholar Rock Inc | Izoform selektivni inhibitori tgfbeta1 i njihova upotreba |
| WO2020076969A2 (en) | 2018-10-10 | 2020-04-16 | Tilos Therapeutics, Inc. | Anti-lap antibody variants and uses thereof |
| CA3118186A1 (en) * | 2018-11-05 | 2020-05-14 | Ludwig Institute For Cancer Research Ltd | Humanized and variant tgf-.beta.1 specific antibodies and methods and uses thereof |
| EA202192130A1 (ru) | 2019-01-30 | 2021-12-28 | Сколар Рок, Инк. | Специфичные к ltbp-комплексу ингибиторы tgf и их применение |
| CA3135988C (en) * | 2019-06-10 | 2024-11-19 | Shandong Boan Biotechnology Co., Ltd. | Bifunctional fusion protein against PD-L1 and TGFS and its use |
| KR102823692B1 (ko) | 2019-08-28 | 2025-06-20 | 추가이 세이야쿠 가부시키가이샤 | 종교차성 항잠재형 TGF-β1 항체 및 사용 방법 |
| CN115190812A (zh) | 2020-01-11 | 2022-10-14 | 供石公司 | TGFβ抑制剂及其用途 |
| CA3166328A1 (en) * | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| EP4126919A1 (en) * | 2020-03-24 | 2023-02-08 | Bio-Techne Corporation | Methods of using a tgf beta knockout cell line and compositions resulting therefrom |
| BR112023014319A2 (pt) * | 2021-01-18 | 2023-09-26 | Jiangxi Jemincare Group Co Ltd | Anticorpo contra a proteína garp e aplicação do mesmo |
| WO2022180764A1 (en) | 2021-02-26 | 2022-09-01 | Chugai Seiyaku Kabushiki Kaisha | Uses of cross-species anti-latent tgf-beta 1 antibodies |
| JP7280400B2 (ja) * | 2021-02-26 | 2023-05-23 | 中外製薬株式会社 | 種交差性抗潜在型ＴＧＦ－β１抗体の使用 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| CN117043187A (zh) * | 2021-03-29 | 2023-11-10 | 山东先声生物制药有限公司 | GARP/TGFβ1抗体及其应用 |
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| EP4499680A1 (en) | 2022-03-29 | 2025-02-05 | Allogene Therapeutics, Inc. | Chimeric switch receptors for the conversion of immunesuppressive signals to costimulatory signals |
| WO2024023283A1 (en) | 2022-07-29 | 2024-02-01 | Institut National de la Santé et de la Recherche Médicale | Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas |
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| TW202434643A (zh) * | 2023-01-09 | 2024-09-01 | 大陸商北京拓界生物醫藥科技有限公司 | ＴＧＦβ１結合分子、ＧＡＲＰ－ＴＧＦβ１結合分子及其醫藥用途 |
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| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
| CN120131938B (zh) * | 2025-03-19 | 2025-12-23 | 广州奥奇生物技术有限公司 | 一种益生菌制剂的制备方法及其在改善睡眠中的应用 |
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| DK3365368T3 (da) | 2023-06-26 |
| KR20180122397A (ko) | 2018-11-12 |
| JP2023108057A (ja) | 2023-08-03 |
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| EA201891909A1 (ru) | 2019-02-28 |
| HUE062976T2 (hu) | 2023-12-28 |
| EP3365368B1 (en) | 2023-05-17 |
| US20230348583A1 (en) | 2023-11-02 |
| KR20250011248A (ko) | 2025-01-21 |
| CA3055555A1 (en) | 2017-09-14 |
| IL261442A (en) | 2018-10-31 |
| IL307835A (en) | 2023-12-01 |
| CN109071646A (zh) | 2018-12-21 |
| US20190071493A1 (en) | 2019-03-07 |
| JP2019509737A (ja) | 2019-04-11 |
| AU2017230103A1 (en) | 2018-09-06 |
| AU2024202692A1 (en) | 2024-05-30 |
| PL3365368T3 (pl) | 2023-08-21 |
| JP2022028680A (ja) | 2022-02-16 |
| BR112018068340A2 (pt) | 2019-01-15 |
| SG11201807176XA (en) | 2018-09-27 |
| MX2024005811A (es) | 2024-05-28 |
| KR20230088508A (ko) | 2023-06-19 |
| FI3365368T3 (fi) | 2023-06-13 |
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| WO2017156500A9 (en) | 2018-02-22 |
| US11643459B2 (en) | 2023-05-09 |
| WO2017156500A1 (en) | 2017-09-14 |
| JP2022031403A (ja) | 2022-02-18 |
| MX2018010948A (es) | 2019-06-20 |
| PT3365368T (pt) | 2023-08-17 |
| EP4169942A1 (en) | 2023-04-26 |
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