ES2939534T3 - Activación moduladora de inflamasomas de células supresoras derivadas de mieloides para tratar EICH - Google Patents

Activación moduladora de inflamasomas de células supresoras derivadas de mieloides para tratar EICH Download PDF

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Publication number
ES2939534T3
ES2939534T3 ES20153949T ES20153949T ES2939534T3 ES 2939534 T3 ES2939534 T3 ES 2939534T3 ES 20153949 T ES20153949 T ES 20153949T ES 20153949 T ES20153949 T ES 20153949T ES 2939534 T3 ES2939534 T3 ES 2939534T3
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Prior art keywords
mdsc
mdscs
gvhd
inflammasome
asc
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ES20153949T
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English (en)
Spanish (es)
Inventor
Bruce R Blazar
Brent H Koehn
Peter J Murray
Jenny P Y Ting
Robert Zeiser
Jeff S Miller
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Albert Ludwigs Universitaet Freiburg
University of North Carolina at Chapel Hill
St Jude Childrens Research Hospital
University of Minnesota Twin Cities
University of Minnesota System
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Albert Ludwigs Universitaet Freiburg
University of North Carolina at Chapel Hill
St Jude Childrens Research Hospital
University of Minnesota Twin Cities
University of Minnesota System
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0642Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00Cellular immunotherapy
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
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    • A61K40/41Vertebrate antigens
    • A61K40/418Antigens related to induction of tolerance to non-self
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    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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    • C12N2501/20Cytokines; Chemokines
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES20153949T 2015-08-06 2016-08-05 Activación moduladora de inflamasomas de células supresoras derivadas de mieloides para tratar EICH Active ES2939534T3 (es)

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US201562201990P 2015-08-06 2015-08-06

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ES2939534T3 true ES2939534T3 (es) 2023-04-24

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ES20153949T Active ES2939534T3 (es) 2015-08-06 2016-08-05 Activación moduladora de inflamasomas de células supresoras derivadas de mieloides para tratar EICH
ES16751781T Active ES2789574T3 (es) 2015-08-06 2016-08-05 Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor

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ES16751781T Active ES2789574T3 (es) 2015-08-06 2016-08-05 Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor

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US (2) US10894061B2 (OSRAM)
EP (3) EP3682889B1 (OSRAM)
JP (3) JP6927499B2 (OSRAM)
CN (2) CN114790447A (OSRAM)
AU (2) AU2016303622B2 (OSRAM)
CA (1) CA2993806A1 (OSRAM)
ES (2) ES2939534T3 (OSRAM)
PT (1) PT3682889T (OSRAM)
WO (1) WO2017024213A1 (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2993806A1 (en) 2015-08-06 2017-02-09 Regents Of The University Of Minnesota Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor
FR3100715B1 (fr) * 2019-09-12 2023-09-29 Francais Du Sang Ets Utilisation de HDL dans la prophylaxie de la maladie du greffon contre l’hôte
WO2022216615A1 (en) * 2021-04-05 2022-10-13 Rhode Island Hospital Compositions and methods for the prevention or treatment of rheumatoid arthritis
CN113707223A (zh) * 2021-04-21 2021-11-26 吴安华 一种预测肿瘤炎性小体活性状态及治疗敏感性的基因集系统及方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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US20040136973A1 (en) 2002-11-07 2004-07-15 Eliezer Huberman Human stem cell materials and methods
EP2300000A1 (en) 2008-07-03 2011-03-30 University of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
US8334101B2 (en) 2008-09-26 2012-12-18 University Of Massachusetts Intracellular DNA receptor
US20120082688A1 (en) * 2008-11-26 2012-04-05 Mount Sinai School Of Medicine In Vitro Generation of Myeloid Derived Suppressor Cells
EP2515919A2 (en) * 2009-12-22 2012-10-31 Mount Sinai School of Medicine Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases
US20140377278A1 (en) 2012-01-10 2014-12-25 Yale University Compositions and Methods for Assessing and Treating Inflammatory Diseases and Disorders
AR095882A1 (es) * 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
WO2015016178A1 (ja) 2013-07-29 2015-02-05 国立大学法人鹿児島大学 1,5-d-アンヒドロフルクトースを含むアポトーシス関連スペック様カード蛋白質の機能阻害薬
MX393750B (es) * 2014-12-31 2025-03-24 Checkmate Pharmaceuticals Inc Inmunoterapia antitumoral combinada.
PL3656443T3 (pl) * 2015-01-21 2022-01-31 The Board Of Trustees Of The Leland Stanford Junior University Zastosowanie agonisty trl i środka anty-cd47 do wzmocnienia fagotocytozy komórek nowotworowych
CA2993806A1 (en) * 2015-08-06 2017-02-09 Regents Of The University Of Minnesota Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor
US11047114B2 (en) 2015-11-13 2021-06-29 Qf Technologies As Method and device to collect water
GB201721185D0 (en) * 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
CN112646777B (zh) * 2020-12-31 2022-11-04 广州医科大学 一种扩增髓系来源的抑制性细胞的方法

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Publication number Publication date
PT3682889T (pt) 2023-03-09
EP3331538A1 (en) 2018-06-13
HK1256917A1 (en) 2019-10-04
CA2993806A1 (en) 2017-02-09
JP2023053338A (ja) 2023-04-12
AU2016303622B2 (en) 2022-07-07
EP3682889A1 (en) 2020-07-22
EP4218776A2 (en) 2023-08-02
CN108883131B (zh) 2022-04-29
ES2789574T3 (es) 2020-10-26
AU2016303622A1 (en) 2018-02-22
US20180214483A1 (en) 2018-08-02
JP2018536620A (ja) 2018-12-13
AU2022228188A1 (en) 2022-09-29
WO2017024213A1 (en) 2017-02-09
AU2016303622A8 (en) 2018-05-31
EP3682889B1 (en) 2023-02-01
CN108883131A (zh) 2018-11-23
JP2021167345A (ja) 2021-10-21
CN114790447A (zh) 2022-07-26
JP6927499B2 (ja) 2021-09-01
US20210128612A1 (en) 2021-05-06
US12234480B2 (en) 2025-02-25
JP7235259B2 (ja) 2023-03-08
US10894061B2 (en) 2021-01-19
EP3331538B1 (en) 2020-03-11
EP4218776A3 (en) 2024-02-28

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