ES2928757T3 - Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa - Google Patents

Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa Download PDF

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ES2928757T3
ES2928757T3 ES16719917T ES16719917T ES2928757T3 ES 2928757 T3 ES2928757 T3 ES 2928757T3 ES 16719917 T ES16719917 T ES 16719917T ES 16719917 T ES16719917 T ES 16719917T ES 2928757 T3 ES2928757 T3 ES 2928757T3
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mmol
pyrrolo
tert
reaction
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Inventor
Atli Thorarensen
Matthew Frank Brown
Agustin Casimiro-Garcia
Ye Che
Mark Edward Flanagan
Adam Matthew Gilbert
Matthew Merrill Hayward
Jean-Baptiste Telliez
Rayomand Jal Unwalla
John I Trujillo
Sidney Xi Liang
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Pfizer Inc
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Pfizer Inc
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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ES16719917T 2015-05-01 2016-04-19 Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa Active ES2928757T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562155824P 2015-05-01 2015-05-01
PCT/IB2016/052220 WO2016178110A1 (en) 2015-05-01 2016-04-19 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof

Publications (1)

Publication Number Publication Date
ES2928757T3 true ES2928757T3 (es) 2022-11-22

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ES16719917T Active ES2928757T3 (es) 2015-05-01 2016-04-19 Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa

Country Status (8)

Country Link
US (1) US10703756B2 (https=)
EP (1) EP3288943B1 (https=)
JP (1) JP6761815B2 (https=)
AR (1) AR104461A1 (https=)
CA (1) CA2984183C (https=)
ES (1) ES2928757T3 (https=)
TW (1) TW201706274A (https=)
WO (1) WO2016178110A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382482A (zh) * 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
US11957931B2 (en) * 2017-04-26 2024-04-16 Yale University Compositions and methods for treating vitiligo
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
MY200629A (en) 2017-08-01 2024-01-06 Theravance Biopharma R&D Ip Llc Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
MX2021000887A (es) 2018-08-01 2021-03-31 Araxes Pharma Llc Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer.
WO2020033955A1 (en) 2018-08-10 2020-02-13 Aclaris Therapeutics, Inc. Pyrrolopyrimidine itk inhibitors
CA3125039A1 (en) 2019-01-23 2020-07-30 Theravance Biopharma R&D Ip, Llc Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors
CN112430235B (zh) * 2019-08-26 2024-04-05 东莞市东阳光仿制药研发有限公司 一种pf-06651600中间体的制备方法
KR102228668B1 (ko) * 2019-10-08 2021-03-17 (주)부흥산업사 메틸피퍼리딘 아미노피롤로 피리미딘의 제조방법
CN111407767B (zh) * 2020-03-28 2021-05-25 中山大学 一种磺胺间甲氧嘧啶衍生物在制备抗肿瘤药物中的应用
WO2023151069A1 (zh) * 2022-02-14 2023-08-17 湖南南新制药股份有限公司 吡咯并[2,3-d]六元杂芳环衍生物、其制备方法和药物用途
CN119060058A (zh) * 2024-08-21 2024-12-03 武汉九州钰民医药科技有限公司 一种甲苯磺酸利特昔替尼的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9911365A (pt) 1998-06-19 2001-03-13 Pfizer Prod Inc Compostos pirrolo[2,3-d]pirimidina
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
EP1382339B1 (en) 1999-12-10 2007-12-05 Pfizer Products Inc. Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives
IL152771A0 (en) 2000-06-26 2003-06-24 Pfizer Prod Inc PYRROLO(2,3-d) PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
KR100678800B1 (ko) 2002-11-21 2007-02-05 화이자 프로덕츠 인코포레이티드 3-아미노-피페리딘 유도체 및 그의 제조 방법
US7491827B2 (en) 2002-12-23 2009-02-17 Millennium Pharmaceuticals, Inc. Aryl sulfonamides useful as inhibitors of chemokine receptor activity
CN1863813B (zh) 2003-08-27 2011-03-30 生物区科学管理控股有限公司 作为治疗剂的三环核苷或核苷酸
BRPI0613876A2 (pt) 2005-07-29 2011-02-15 Pfizer Prod Inc derivados de pirrolo [2,3-d] pirimidina; seus intermediários e sìntese
JP5098843B2 (ja) 2007-06-29 2012-12-12 Ｊｆｅスチール株式会社 金属試料中の着目元素の固溶含有率を求める方法
JP5368485B2 (ja) * 2008-02-25 2013-12-18 エフ．ホフマン−ラ ロシュ アーゲー ピロロピラジンキナーゼインヒビター
ES2378513T3 (es) 2008-08-06 2012-04-13 Pfizer Inc. Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1
PT2473049T (pt) 2009-09-04 2019-03-04 Sunesis Pharmaceuticals Inc Inibidores de tirosina quinase de bruton
CA2799904A1 (en) * 2010-05-20 2011-11-24 F. Hoffmann-La Roche Ag Pyrrolo [2, 3 - b] pyrazine - 7 - carboxamide derivatives and their use as jak and syk inhibitors
US9206188B2 (en) * 2013-04-18 2015-12-08 Arrien Pharmaceuticals Llc Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
MX368464B (es) 2013-12-05 2019-10-02 Pfizer Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo.

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TW201706274A (zh) 2017-02-16
AR104461A1 (es) 2017-07-19
CA2984183C (en) 2021-11-09
EP3288943A1 (en) 2018-03-07
EP3288943B1 (en) 2022-09-28
US10703756B2 (en) 2020-07-07
JP6761815B2 (ja) 2020-09-30
WO2016178110A1 (en) 2016-11-10
CA2984183A1 (en) 2016-11-10
JP2018514560A (ja) 2018-06-07
US20190002466A1 (en) 2019-01-03

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