ES2927294T3 - Tratamiento de combinación de la enfermedad artrítica - Google Patents

Tratamiento de combinación de la enfermedad artrítica Download PDF

Info

Publication number
ES2927294T3
ES2927294T3 ES20723141T ES20723141T ES2927294T3 ES 2927294 T3 ES2927294 T3 ES 2927294T3 ES 20723141 T ES20723141 T ES 20723141T ES 20723141 T ES20723141 T ES 20723141T ES 2927294 T3 ES2927294 T3 ES 2927294T3
Authority
ES
Spain
Prior art keywords
acid
compound
use according
mtx
arthritis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20723141T
Other languages
English (en)
Spanish (es)
Inventor
Thomas Jonassen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synact Pharma ApS
Original Assignee
Synact Pharma ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synact Pharma ApS filed Critical Synact Pharma ApS
Application granted granted Critical
Publication of ES2927294T3 publication Critical patent/ES2927294T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES20723141T 2019-05-10 2020-05-07 Tratamiento de combinación de la enfermedad artrítica Active ES2927294T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19173734 2019-05-10
PCT/EP2020/062711 WO2020229297A1 (en) 2019-05-10 2020-05-07 Combination treatment of arthritic disease

Publications (1)

Publication Number Publication Date
ES2927294T3 true ES2927294T3 (es) 2022-11-04

Family

ID=66483881

Family Applications (2)

Application Number Title Priority Date Filing Date
ES20723141T Active ES2927294T3 (es) 2019-05-10 2020-05-07 Tratamiento de combinación de la enfermedad artrítica
ES22178594T Active ES3041907T3 (en) 2019-05-10 2020-05-07 Phenyl pyrrole aminoguanidine derivatives in combination with methotrexate for use in the treatment of arthritic disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES22178594T Active ES3041907T3 (en) 2019-05-10 2020-05-07 Phenyl pyrrole aminoguanidine derivatives in combination with methotrexate for use in the treatment of arthritic disease

Country Status (21)

Country Link
US (2) US12303489B2 (https=)
EP (2) EP3773558B1 (https=)
JP (1) JP7546599B2 (https=)
KR (1) KR20220006551A (https=)
CN (1) CN113795250B (https=)
AU (1) AU2020273479B2 (https=)
BR (1) BR112021022397A2 (https=)
CA (1) CA3139000A1 (https=)
CY (1) CY1125564T1 (https=)
DK (1) DK3773558T3 (https=)
ES (2) ES2927294T3 (https=)
HU (1) HUE059638T2 (https=)
IL (1) IL287904B2 (https=)
LT (1) LT3773558T (https=)
MX (1) MX2021013296A (https=)
PL (1) PL3773558T3 (https=)
PT (1) PT3773558T (https=)
SG (1) SG11202111821SA (https=)
SI (1) SI3773558T1 (https=)
WO (1) WO2020229297A1 (https=)
ZA (1) ZA202108219B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3773558T (lt) 2019-05-10 2022-09-12 Synact Pharma Aps Kompleksinis artrito gydymas
CN120617247A (zh) * 2020-03-31 2025-09-12 西奈克制药有限公司 症状性病毒性疾病的治疗
WO2022223778A1 (en) 2021-04-23 2022-10-27 Helmholtz-Zentrum für Infektionsforschung GmbH Citraconic acid and derivatives thereof for use as a medicament
EP4359076B1 (en) 2021-06-21 2025-08-06 SynAct Pharma ApS Phenyl pyrrole aminoguanidine salts and formulations
US20250032449A1 (en) * 2021-11-29 2025-01-30 Synact Pharma Aps Treatment of rheumatoid arthritis
WO2023218048A1 (en) * 2022-05-12 2023-11-16 Synact Pharma Aps Resomelagon and its derivatives for the treatment of cardiovascular disease, hypertension and atherosclerosis
CN120584099A (zh) * 2022-12-21 2025-09-02 西奈克制药有限公司 苯基吡咯肼甲脒化合物的多晶型物
WO2025124760A1 (en) 2023-12-11 2025-06-19 Synact Pharma Aps Treatment of subpopulation of patients with rheumatoid arthritis
WO2026049571A1 (ko) * 2024-08-29 2026-03-05 루다큐어 주식회사 통증 치료용 조성물

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9604348D0 (sv) 1996-11-26 1996-11-26 Wapharm Ab Användning av hydroxyguanidiner
WO1999021571A1 (en) 1997-10-27 1999-05-06 Trega Biosciences, Inc. Melanocortin receptor ligands and methods of using same
EP1076649A4 (en) 1998-04-28 2010-06-02 Trega Biosciences Inc ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE
WO1999064002A1 (en) 1998-06-11 1999-12-16 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
CA2368431C (en) 1999-03-29 2006-01-24 The Procter & Gamble Company Melanocortin receptor ligands
CA2377369A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
WO2001005401A1 (en) 1999-07-16 2001-01-25 Trega Biosciences, Inc. Melanocortin receptor-3 ligands to treat sexual dysfunction
ES2316383T3 (es) 1999-09-17 2009-04-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
CZ2002959A3 (cs) 1999-09-17 2002-07-17 Millennium Pharmaceuticals, Inc. Inhibitory faktoru Xa
WO2001055107A2 (en) 2000-01-28 2001-08-02 Melacure Therapeutics Ab Aromatic amines and amides acting on the melanocortin receptors
WO2001055106A2 (en) 2000-01-28 2001-08-02 Melacure Therapeutics Ab Novel melanocortin receptor agonists and antagonists
GB0002059D0 (en) 2000-01-28 2000-03-22 Melacure Therapeutics Ab Novel aromatic amines
KR100440370B1 (ko) 2000-04-01 2004-07-19 (주)명문엘씨 2중 사출에 의한 밀폐용기 뚜껑
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
GB0019359D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel guanidines
DZ3415A1 (fr) 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
EP1370211A4 (en) 2001-03-02 2005-02-09 Bristol Myers Squibb Co SIMULTANEOUS ADMINISTRATION OF MELANOCORTIN RECEPTOR AGONISTS AND A PHOSPHODIESTERASE HEMMER FOR THE TREATMENT OF DISEASES RELATED TO CYCLIC AMP
GB0119172D0 (en) 2001-08-06 2001-09-26 Melacure Therapeutics Ab Phenyl pyrrole derivatives
CA2363528A1 (en) 2001-11-19 2003-05-19 Merck Patent Gesellschaft Mit Beschraenkter Haftung Immediate release tablet containing naproxen sodium
GB2398299A (en) 2003-02-13 2004-08-18 Melacure Therapeutics Ab Pharmaceutically active phenyl-pyrrole derivatives
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
NZ573457A (en) * 2006-06-09 2011-06-30 Action Pharma As Phenyl pyrrole aminoguanidine derivatives
GB0624987D0 (en) 2006-12-14 2007-01-24 Acure Pharma Ab Novel aminoguanidines as melanocortin receptor ligands
EP2045250A1 (en) 2007-09-26 2009-04-08 Action Pharma A/S Ring-substituted phenyl pyrrole aminoguanidine derivatives
WO2009071101A1 (en) 2007-12-07 2009-06-11 Action Pharma A/S N-modified aminoguanidine derivatives
WO2009074157A1 (en) 2007-12-13 2009-06-18 Action Pharma A/S Fully-modified phenyl pyrrole aminoguanidines
US10387927B2 (en) 2010-01-15 2019-08-20 Dell Products L.P. System and method for entitling digital assets
JP2011190199A (ja) * 2010-03-12 2011-09-29 Hideto Nakamura 関節リウマチ薬
US9662807B2 (en) 2011-12-21 2017-05-30 GKN Aerospace Services Structures, Corp. Method for forming a fabric preform for a composite material by separately tensioning tows
RU2668791C2 (ru) 2012-10-19 2018-10-02 ТиЭксПи ФАРМА ГМБХ АНАЛОГИ АЛЬФА- и ГАММА-MSH
MX373894B (es) * 2012-11-08 2020-07-09 Clearside Biomedical Inc Métodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos.
US9917808B2 (en) 2013-03-14 2018-03-13 International Business Machines Corporation Grouping electronic messages
WO2015162486A1 (en) 2014-04-22 2015-10-29 Txp Pharma Gmbh Linear gamma msh with c- and / or n-terminal extensions of lysine and / or glutamic acid residues
WO2015162483A1 (en) 2014-04-22 2015-10-29 Txp Pharma Gmbh Alpha- and gamma-msh analogues
CN112292125B (zh) 2018-06-22 2023-10-31 西奈克制药有限公司 蛋白尿的治疗
WO2020107221A1 (en) 2018-11-27 2020-06-04 Tsinghua University Chemical activators of nicotinamide mononucleotide adenlyly transferase 2 (nmnat2) and uses thereof
LT3773558T (lt) 2019-05-10 2022-09-12 Synact Pharma Aps Kompleksinis artrito gydymas
CN113730797B (zh) 2020-05-29 2023-05-16 创领心律管理医疗器械（上海）有限公司 电极板及可穿戴式除颤设备

Also Published As

Publication number Publication date
US20220211666A1 (en) 2022-07-07
LT3773558T (lt) 2022-09-12
IL287904A (en) 2022-01-01
US12303489B2 (en) 2025-05-20
CN113795250B (zh) 2024-10-15
KR20220006551A (ko) 2022-01-17
JP2022531906A (ja) 2022-07-12
ES3041907T3 (en) 2025-11-17
PT3773558T (pt) 2022-09-13
CY1125564T1 (el) 2026-02-25
EP3773558A1 (en) 2021-02-17
EP4119140A1 (en) 2023-01-18
US20250387365A1 (en) 2025-12-25
IL287904B2 (en) 2026-03-01
SI3773558T1 (sl) 2022-11-30
AU2020273479A1 (en) 2021-12-23
DK3773558T3 (da) 2022-09-19
EP4119140C0 (en) 2025-06-25
EP4119140B1 (en) 2025-06-25
IL287904B1 (en) 2025-11-01
WO2020229297A1 (en) 2020-11-19
PL3773558T3 (pl) 2022-10-03
JP7546599B2 (ja) 2024-09-06
HUE059638T2 (hu) 2022-12-28
CA3139000A1 (en) 2020-11-19
SG11202111821SA (en) 2021-11-29
ZA202108219B (en) 2023-03-29
EP3773558B1 (en) 2022-06-15
AU2020273479B2 (en) 2025-02-27
MX2021013296A (es) 2021-12-15
CN113795250A (zh) 2021-12-14
BR112021022397A2 (pt) 2021-12-28

Similar Documents

Publication Publication Date Title
ES2927294T3 (es) Tratamiento de combinación de la enfermedad artrítica
Volpi et al. Type I interferon pathway activation in COPA syndrome
US8784812B2 (en) Methods for treating autoimmune diseases using a TACI-Ig fusion molecule
Furst Mechanism of action, pharmacology, clinical efficacy and side effects of auranofin: an orally administered organic gold compound for the treatment of rheumatoid arthritis
EP4440572A1 (en) Treatment of rheumatoid arthritis
RU2828044C2 (ru) Комбинированное лечение артрита
HK40047132A (en) Combination treatment of arthritic disease
HK40047132B (en) Combination treatment of arthritic disease
Smyth et al. A Method for Measuring Swelling of Hands and Feet Part II: Influence of New Anti-Inflammatory Drug, Indomethacin, in Acute Gout
Sharma et al. Juvenile idiopathic arthritis: a review
WO2025124760A1 (en) Treatment of subpopulation of patients with rheumatoid arthritis
JP2024020797A (ja) 筋萎縮の治療剤
Fukunaga et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid
Vijarnsorn Investigation of anti-arthritic effects of a new glucosamine formulation (ONC114).
Vijarnsorn Investigation of Anti-arthritic Effects of a New Glucosamine Formulation (ONC114).
Ahmad et al. A comprehensive textbook of psoriasis
Dorph Studies on interleukin-1 in idiopathic inflammatory myopathies