ES2926984T3 - Dispositivo para el tratamiento fotodinámico - Google Patents
Dispositivo para el tratamiento fotodinámico Download PDFInfo
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- ES2926984T3 ES2926984T3 ES16815830T ES16815830T ES2926984T3 ES 2926984 T3 ES2926984 T3 ES 2926984T3 ES 16815830 T ES16815830 T ES 16815830T ES 16815830 T ES16815830 T ES 16815830T ES 2926984 T3 ES2926984 T3 ES 2926984T3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/202—Assessing bladder functions, e.g. incontinence assessment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/061—Bladder and/or urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Biophysics (AREA)
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- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
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- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- Radiation-Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1522398.5A GB201522398D0 (en) | 2015-12-18 | 2015-12-18 | Device for photodynamic therapy |
| PCT/EP2016/081425 WO2017103105A1 (en) | 2015-12-18 | 2016-12-16 | Device for photodynamic treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2926984T3 true ES2926984T3 (es) | 2022-10-31 |
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Family Applications (1)
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| ES16815830T Active ES2926984T3 (es) | 2015-12-18 | 2016-12-16 | Dispositivo para el tratamiento fotodinámico |
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| EP (1) | EP3389778B1 (enExample) |
| JP (1) | JP6860571B2 (enExample) |
| KR (1) | KR102666387B1 (enExample) |
| CN (1) | CN108778413B (enExample) |
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| BR (1) | BR112018012182B1 (enExample) |
| CA (1) | CA3008555C (enExample) |
| DK (1) | DK3389778T3 (enExample) |
| ES (1) | ES2926984T3 (enExample) |
| GB (1) | GB201522398D0 (enExample) |
| PL (1) | PL3389778T3 (enExample) |
| RU (1) | RU2736406C2 (enExample) |
| WO (1) | WO2017103105A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102067583B1 (ko) | 2011-12-09 | 2020-01-17 | 메타벤션, 인크. | 간 시스템의 치료적 신경조절 |
| AU2013230776B2 (en) | 2012-03-08 | 2015-12-03 | Medtronic Af Luxembourg S.A.R.L. | Immune system neuromodulation and associated systems and methods |
| AU2015358385B2 (en) | 2014-12-03 | 2020-09-03 | Medtronic Ireland Manufacturing Unlimited Company | Systems and methods for modulating nerves or other tissue |
| US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
| PL3641882T3 (pl) * | 2017-06-21 | 2024-02-26 | Photocure Asa | Sposób przygotowania ciekłej kompozycji farmaceutycznej oraz urządzenie do stosowania w takim sposobie |
| WO2019099036A1 (en) | 2017-11-17 | 2019-05-23 | Convergascent Llc | Devices and systems for intraluminal local drug delivery |
| EP3745951A4 (en) * | 2018-02-02 | 2021-10-20 | University of Health Network | DEVICES, SYSTEMS AND METHODS FOR TUMOR VISUALIZATION AND REMOVAL |
| WO2020037032A1 (en) * | 2018-08-17 | 2020-02-20 | St. Jude Medical, Cardiology Division, Inc. | Optical balloon catheters and methods for mapping and ablation |
| KR20200039066A (ko) | 2018-10-04 | 2020-04-16 | 재단법인 아산사회복지재단 | 광역학 치료 장치 |
| US20220117716A1 (en) * | 2018-12-24 | 2022-04-21 | Innoventions Ltd. | Intravesicular device for controlling urinary incontinence |
| CN120847049A (zh) | 2019-01-17 | 2025-10-28 | 莫勒库莱特股份有限公司 | 便携式手持成像系统 |
| US20200230378A1 (en) * | 2019-01-22 | 2020-07-23 | Olympus Corporation | Balloon catheter system and method for optical tumor treatment |
| WO2020174547A1 (ja) * | 2019-02-25 | 2020-09-03 | 大塚電子株式会社 | 光線力学治療装置 |
| WO2020191400A1 (en) * | 2019-03-21 | 2020-09-24 | The General Hospital Corporation | Systems and methods for catheter based light delivery |
| GB201905940D0 (en) * | 2019-04-29 | 2019-06-12 | Intract Pharma Ltd | 5-aminolevulinic acid for the local treatment of inflammatory bowel disease |
| KR102273928B1 (ko) | 2019-05-15 | 2021-07-14 | 연세대학교 산학협력단 | 집속초음파 유도에 의해 광투과 깊이를 확보하는 광 조사 장치 및 초음파의 출력을 피드백 제어하여 광을 조사하는 방법 |
| US12402946B2 (en) | 2019-06-19 | 2025-09-02 | Boston Scientific Scimed, Inc. | Breakdown of laser pulse energy for breakup of vascular calcium |
| US11517713B2 (en) | 2019-06-26 | 2022-12-06 | Boston Scientific Scimed, Inc. | Light guide protection structures for plasma system to disrupt vascular lesions |
| CN110339489B (zh) * | 2019-08-09 | 2020-07-21 | 尚华 | 一种新型的血管光纤导丝 |
| US12274497B2 (en) | 2019-12-18 | 2025-04-15 | Bolt Medical, Inc. | Multiplexer for laser-driven intravascular lithotripsy device |
| WO2021154682A1 (en) * | 2020-01-27 | 2021-08-05 | Convergascent Llc | Tissue dosing for intraluminal local drug delivery |
| US12446961B2 (en) * | 2020-02-10 | 2025-10-21 | Bolt Medical, Inc. | System and method for pressure monitoring within a catheter system |
| DE102020000934A1 (de) | 2020-02-14 | 2021-08-19 | Albert-Ludwigs-Universität Freiburg | Transurethraler Katheter mit antimikrobieller Wirkung |
| CN111388873A (zh) * | 2020-03-26 | 2020-07-10 | 苏州科技城医院 | 一种基于蓝光led的胃腔光疗杀菌装置及方法 |
| WO2021199976A1 (ja) * | 2020-03-30 | 2021-10-07 | テルモ株式会社 | 治療装置および治療方法 |
| US11918360B1 (en) * | 2020-04-17 | 2024-03-05 | The Brigham And Women's Hospital, Inc. | Systems and methods for examining hollow organs |
| EP4138997A4 (en) * | 2020-04-20 | 2024-04-24 | Cern Corp. | VAGINAL LIGHT THERAPY DEVICES AND METHODS OF USE THEREOF |
| US12295654B2 (en) | 2020-06-03 | 2025-05-13 | Boston Scientific Scimed, Inc. | System and method for maintaining balloon integrity within intravascular lithotripsy device with plasma generator |
| CN112402807B (zh) * | 2020-11-18 | 2021-11-23 | 中国人民解放军总医院 | 一种用于人体腔道及空腔器官内的光动力治疗器械 |
| JP2024504606A (ja) | 2021-01-12 | 2024-02-01 | ボルト メディカル インコーポレイテッド | 弁形成カテーテル・システムのためのバルーン組立体 |
| CN112386810B (zh) * | 2021-01-19 | 2021-04-27 | 武汉亚格光电技术股份有限公司 | 冷却式内腔治疗用光动力治疗头 |
| RU2767264C1 (ru) * | 2021-06-24 | 2022-03-17 | Общество с ограниченной ответственностью "БИОСПЕК" | Способ внутрипротоковой фототераностики холангиоцеллюлярного рака |
| US11839391B2 (en) | 2021-12-14 | 2023-12-12 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
| EP4223365A1 (en) * | 2022-02-08 | 2023-08-09 | Uvisa Health ApS | A device for transmitting light within a body cavity |
| DE102022201337A1 (de) * | 2022-02-09 | 2023-08-10 | Richard Wolf Gmbh | Bestrahlungsvorrichtung für die photodynamische Therapie |
| IL308772A (en) * | 2023-11-22 | 2025-06-01 | Yeda Res & Dev | Photodynamic therapy of tumor by intra-organ illumination |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU664157B2 (en) * | 1990-09-14 | 1995-11-09 | American Medical Systems, Inc. | Combined hyperthermia and dilation catheter |
| US5415654A (en) * | 1993-10-05 | 1995-05-16 | S.L.T. Japan Co., Ltd. | Laser balloon catheter apparatus |
| KR100444007B1 (ko) | 1995-03-10 | 2004-12-03 | 포토큐레 에이에스에이 | 광화학치료또는진단에사용하기위한5-아미노레불린산의에스테르 |
| US6013053A (en) * | 1996-05-17 | 2000-01-11 | Qlt Photo Therapeutics Inc. | Balloon catheter for photodynamic therapy |
| US6146409A (en) * | 1996-05-20 | 2000-11-14 | Bergein F. Overholt | Therapeutic methods and devices for irradiating columnar environments |
| US6299598B1 (en) * | 1997-02-04 | 2001-10-09 | Cook Urological, Incorporated | Drainage catheter |
| US6096030A (en) * | 1997-09-23 | 2000-08-01 | Pharmacyclics, Inc. | Light delivery catheter and PDT treatment method |
| FR2777782B1 (fr) | 1998-04-22 | 2001-05-18 | Alexandre Marti | Solution pour la preparation d'une substance pharmaceutique pour le diagnostic et/ou le traitement de lesions tissulaires |
| GB2360459B (en) | 2000-03-23 | 2002-08-07 | Photo Therapeutics Ltd | Therapeutic light source and method |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| EP1312353A1 (en) | 2001-11-16 | 2003-05-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for hair removal |
| WO2004012805A2 (en) * | 2002-08-05 | 2004-02-12 | Miravant Medical Technologies | Light delivery catheter |
| EP1610865A4 (en) * | 2003-03-14 | 2007-11-28 | Light Sciences Oncology Inc | LIGHT PRODUCTION DEVICE FOR INTRAVASCULAR USE |
| US7135034B2 (en) * | 2003-11-14 | 2006-11-14 | Lumerx, Inc. | Flexible array |
| GB2408209A (en) * | 2003-11-18 | 2005-05-25 | Qinetiq Ltd | Flexible medical light source |
| GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| EP1938801A1 (en) * | 2006-12-22 | 2008-07-02 | Biofrontera Bioscience GmbH | Nanoemulsion |
| GB0724279D0 (en) | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| EP2231105A1 (en) | 2007-12-14 | 2010-09-29 | Photoderma SA | Novel compounds useful in therapeutic and cosmetic methods |
| US20100016844A1 (en) * | 2008-07-21 | 2010-01-21 | Patel Jr Manoj B | Transilluminating foley catheter to facilitate prostate and bladder surgery |
| GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
| CN102458388B (zh) | 2009-06-11 | 2016-09-28 | 光治疗Asa公司 | 半固体组合物及药物制品 |
| PE20120858A1 (es) | 2009-06-11 | 2012-08-01 | Photocure Asa | Composiciones solidas que comprenden acido 5-aminolevulinico |
| GB2505572B (en) * | 2010-04-30 | 2014-08-06 | Abbott Cardiovascular Systems | Catheter system providing step reduction for postconditioning |
| US20130211215A1 (en) | 2010-06-23 | 2013-08-15 | Photocure Asa | Hyperosmotic preparations comprising 5-aminolevulinic acid or derivative as photosensitizing agent |
| KR101842732B1 (ko) | 2010-07-09 | 2018-05-14 | 포토큐어 에이에스에이 | 광역동 치료 또는 광역동 진단에 사용하기 위한 건조 조성물 및 이와 같은 건조 조성물을 포함하는 기구 |
| US10357661B2 (en) | 2011-09-30 | 2019-07-23 | Percuvision, Llc | Medical device and method for internal healing and antimicrobial purposes |
| US9249086B2 (en) | 2012-08-03 | 2016-02-02 | Photocure Asa | Carboxylic acid ALA esters |
| US20140067024A1 (en) * | 2012-08-30 | 2014-03-06 | Photocure Asa | Dual panel photodynamic therapy lamp |
| EP3019238A4 (en) * | 2013-07-10 | 2017-03-29 | Oxys AG | Devices and methods for delivery of therapeutic energy |
| CN203598366U (zh) * | 2013-12-16 | 2014-05-21 | 薛晓英 | 一种前列腺癌放疗使用的直肠内气囊 |
| WO2015160064A1 (ko) * | 2014-04-18 | 2015-10-22 | 부경대학교산학협력단 | 산광형 광섬유를 포함하는 프로브, 그 제조 방법 및 응용 |
| CN203971207U (zh) * | 2014-07-07 | 2014-12-03 | 陆改玲 | 一种激光治疗装置 |
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| JP6860571B2 (ja) | 2021-04-14 |
| GB201522398D0 (en) | 2016-02-03 |
| KR20180095587A (ko) | 2018-08-27 |
| CA3008555A1 (en) | 2017-06-22 |
| RU2018124869A3 (enExample) | 2020-03-10 |
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| CN108778413B (zh) | 2020-09-15 |
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| AU2016369404A1 (en) | 2018-07-12 |
| DK3389778T3 (da) | 2022-09-12 |
| BR112018012182A2 (pt) | 2018-11-27 |
| KR102666387B1 (ko) | 2024-05-14 |
| PL3389778T3 (pl) | 2022-10-10 |
| US11565123B2 (en) | 2023-01-31 |
| JP2018538077A (ja) | 2018-12-27 |
| EP3389778A1 (en) | 2018-10-24 |
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