ES2913929T3 - Compuestos químicos como inhibidores de la ruta de ATF4 - Google Patents

Compuestos químicos como inhibidores de la ruta de ATF4 Download PDF

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ES2913929T3
ES2913929T3 ES17733530T ES17733530T ES2913929T3 ES 2913929 T3 ES2913929 T3 ES 2913929T3 ES 17733530 T ES17733530 T ES 17733530T ES 17733530 T ES17733530 T ES 17733530T ES 2913929 T3 ES2913929 T3 ES 2913929T3
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chlorophenoxy
acetamide
disease
cancer
compound
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Jeffrey Axten
Mui Cheung
Michael P Demartino
Hilary Schenck Eidam
Raghava Reddy Kethiri
Biswajit Kalita
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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