CN109563071B - 作为atf4途径抑制剂的化学化合物 - Google Patents

作为atf4途径抑制剂的化学化合物 Download PDF

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CN109563071B
CN109563071B CN201780048778.1A CN201780048778A CN109563071B CN 109563071 B CN109563071 B CN 109563071B CN 201780048778 A CN201780048778 A CN 201780048778A CN 109563071 B CN109563071 B CN 109563071B
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chlorophenoxy
disease
cancer
acetamide
piperidin
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CN109563071A (zh
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J.阿克斯滕
M.张
M.P.德马蒂诺
H.S.艾达姆
R.R.克西里
B.卡利塔
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GlaxoSmithKline Intellectual Property Development Ltd
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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