ES2908067T3 - Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa - Google Patents

Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa Download PDF

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Publication number
ES2908067T3
ES2908067T3 ES17728776T ES17728776T ES2908067T3 ES 2908067 T3 ES2908067 T3 ES 2908067T3 ES 17728776 T ES17728776 T ES 17728776T ES 17728776 T ES17728776 T ES 17728776T ES 2908067 T3 ES2908067 T3 ES 2908067T3
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ES
Spain
Prior art keywords
galactose
peracetyl
cell
peracetyl galactose
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17728776T
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English (en)
Spanish (es)
Inventor
Martin Jordan
Gabrielle Leclercq
Jonathan Souquet
Hervé Broly
David Bruhlmann
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Ares Trading SA
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Ares Trading SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES17728776T 2016-05-10 2017-05-10 Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa Active ES2908067T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16169062 2016-05-10
PCT/EP2017/061181 WO2017194605A1 (en) 2016-05-10 2017-05-10 Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose

Publications (1)

Publication Number Publication Date
ES2908067T3 true ES2908067T3 (es) 2022-04-27

Family

ID=56026651

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17728776T Active ES2908067T3 (es) 2016-05-10 2017-05-10 Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa

Country Status (9)

Country Link
US (1) US11118208B2 (https=)
EP (1) EP3455363B1 (https=)
JP (1) JP6882339B2 (https=)
CN (1) CN109072273B (https=)
AU (2) AU2017264541A1 (https=)
CA (1) CA3022769A1 (https=)
ES (1) ES2908067T3 (https=)
IL (1) IL262875B (https=)
WO (1) WO2017194605A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3397282A4 (en) 2015-12-30 2019-08-07 Momenta Pharmaceuticals, Inc. METHODS RELATING TO BIOLOGICA
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
AU2019336148B2 (en) 2018-09-06 2025-08-14 Momenta Pharmaceuticals, Inc. Methods of continuous cell culture
WO2020142275A1 (en) * 2018-12-31 2020-07-09 Momenta Pharmaceuticals, Inc. Methods of producing ustekinumab
CN113549667A (zh) * 2021-07-21 2021-10-26 杭州奕安济世生物药业有限公司 一种降低抗体半乳糖基化的方法
AU2023223660A1 (en) * 2022-02-25 2024-08-01 Kashiv Biosciences, Llc A process for improving polypeptide expression in mammalian cell culture
CN121058875A (zh) * 2025-10-11 2025-12-05 广东海洋大学 一种负载脂溶性多酚的碱诱导糖基化罗非鱼蛋白水解物及其制备方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163551B2 (en) * 2008-05-02 2012-04-24 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
DK2608796T3 (en) * 2010-08-05 2019-03-18 Seattle Genetics Inc Inhibition of protein fucosylation in vivo using fucose analogues
WO2015115849A1 (ko) * 2014-01-29 2015-08-06 주식회사 엘지생명과학 배양배지의 최적화를 통한 재조합 단백질의 갈락토오스화를 조절하는 방법
US20160039924A1 (en) * 2014-08-05 2016-02-11 Abbvie Inc. Methods for modulating the glycosylation profile of recombinant proteins using dissolved oxygen

Also Published As

Publication number Publication date
JP2019514411A (ja) 2019-06-06
US20190153497A1 (en) 2019-05-23
JP6882339B2 (ja) 2021-06-02
IL262875B (en) 2022-05-01
CA3022769A1 (en) 2017-11-16
EP3455363A1 (en) 2019-03-20
AU2021258023A1 (en) 2021-11-25
AU2021258023B2 (en) 2023-11-16
US11118208B2 (en) 2021-09-14
WO2017194605A1 (en) 2017-11-16
EP3455363B1 (en) 2021-12-08
CN109072273A (zh) 2018-12-21
CN109072273B (zh) 2022-04-15
IL262875A (en) 2018-12-31
AU2017264541A1 (en) 2018-12-13

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