ES2907676T3 - Inhibidores de la desmetilasa 1 específica de lisina - Google Patents

Inhibidores de la desmetilasa 1 específica de lisina Download PDF

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Publication number
ES2907676T3
ES2907676T3 ES15814038T ES15814038T ES2907676T3 ES 2907676 T3 ES2907676 T3 ES 2907676T3 ES 15814038 T ES15814038 T ES 15814038T ES 15814038 T ES15814038 T ES 15814038T ES 2907676 T3 ES2907676 T3 ES 2907676T3
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Spain
Prior art keywords
optionally substituted
compound
pharmaceutically acceptable
heterocyclyl
acceptable salt
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Active
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ES15814038T
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English (en)
Spanish (es)
Inventor
Young K Chen
Toufike Kanouni
Zhe Nie
Jeffrey Alan Stafford
James Marvin Veal
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Celgene Quanticel Research Inc
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Celgene Quanticel Research Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyamides (AREA)
ES15814038T 2014-07-03 2015-06-29 Inhibidores de la desmetilasa 1 específica de lisina Active ES2907676T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462020886P 2014-07-03 2014-07-03
PCT/US2015/038345 WO2016003917A1 (en) 2014-07-03 2015-06-29 Inhibitors of lysine specific demethylase-1

Publications (1)

Publication Number Publication Date
ES2907676T3 true ES2907676T3 (es) 2022-04-26

Family

ID=55019883

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15814038T Active ES2907676T3 (es) 2014-07-03 2015-06-29 Inhibidores de la desmetilasa 1 específica de lisina
ES19156976T Active ES2948782T3 (es) 2014-07-03 2015-06-29 Inhibidores de la desmetilasa 1 específica de lisina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES19156976T Active ES2948782T3 (es) 2014-07-03 2015-06-29 Inhibidores de la desmetilasa 1 específica de lisina

Country Status (29)

Country Link
US (3) US9902719B2 (index.php)
EP (2) EP3511319B1 (index.php)
JP (2) JP6663866B2 (index.php)
KR (1) KR102475498B1 (index.php)
CN (2) CN108530424B (index.php)
AU (1) AU2015284383B2 (index.php)
BR (1) BR112017000043A2 (index.php)
CA (1) CA2954049A1 (index.php)
CL (1) CL2016003422A1 (index.php)
CO (1) CO2017000549A2 (index.php)
CY (1) CY1125127T1 (index.php)
DK (2) DK3164380T3 (index.php)
EA (2) EA201891526A3 (index.php)
EC (1) ECSP17006821A (index.php)
ES (2) ES2907676T3 (index.php)
FI (1) FI3511319T3 (index.php)
HR (2) HRP20220414T1 (index.php)
HU (2) HUE058852T2 (index.php)
IL (2) IL249881B (index.php)
LT (2) LT3511319T (index.php)
MX (2) MX395534B (index.php)
PL (2) PL3164380T3 (index.php)
PT (2) PT3164380T (index.php)
RS (2) RS64423B1 (index.php)
SA (1) SA517380651B1 (index.php)
SG (2) SG11201610975RA (index.php)
SI (2) SI3164380T1 (index.php)
SM (2) SMT202300205T1 (index.php)
WO (1) WO2016003917A1 (index.php)

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JP7158023B2 (ja) 2016-03-15 2022-10-21 オリソン ヘノミクス エセ． アー． 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ
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CN116102533A (zh) * 2021-11-11 2023-05-12 中国科学院上海药物研究所 一种芳杂环类化合物及其应用
CN119497613A (zh) 2022-05-09 2025-02-21 奥莱松基因组股份有限公司 使用lsd1抑制剂治疗nf1-突变肿瘤的方法
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CN106795103A (zh) 2017-05-31
RS63074B1 (sr) 2022-04-29
PL3164380T3 (pl) 2022-04-04
EA201891526A3 (ru) 2019-05-31
JP6663866B2 (ja) 2020-03-13
DK3164380T3 (da) 2022-03-28
MX376207B (es) 2025-03-07
ES2948782T3 (es) 2023-09-19
EA201790085A1 (ru) 2017-08-31
CN108530424A (zh) 2018-09-14
IL272130B (en) 2021-03-25
LT3164380T (lt) 2022-06-27
KR102475498B1 (ko) 2022-12-07
AU2015284383B2 (en) 2019-04-18
EP3164380A1 (en) 2017-05-10
CL2016003422A1 (es) 2017-11-10
WO2016003917A1 (en) 2016-01-07
SG10201802501RA (en) 2018-05-30
US9902719B2 (en) 2018-02-27
FI3511319T3 (fi) 2023-07-20
CO2017000549A2 (es) 2017-04-20
US20180127408A1 (en) 2018-05-10
US20170129882A1 (en) 2017-05-11
JP2019108346A (ja) 2019-07-04
EP3164380B1 (en) 2022-02-09
HUE062558T2 (hu) 2023-11-28
SI3511319T1 (sl) 2023-10-30
IL272130A (en) 2020-03-31
LT3511319T (lt) 2023-08-25
EP3164380A4 (en) 2018-07-18
MX2020010900A (es) 2022-09-13
SG11201610975RA (en) 2017-01-27
HRP20230595T1 (hr) 2023-09-15
US10100046B2 (en) 2018-10-16
HRP20220414T1 (hr) 2022-05-27
MX395534B (es) 2025-03-25
CN106795103B (zh) 2019-07-12
EA033698B1 (ru) 2019-11-18
CA2954049A1 (en) 2016-01-07
SI3164380T1 (sl) 2022-06-30
JP6768857B2 (ja) 2020-10-14
SMT202300205T1 (it) 2023-09-06
PT3511319T (pt) 2023-06-29
DK3511319T3 (da) 2023-07-31
HUE058852T2 (hu) 2022-09-28
IL249881B (en) 2020-01-30
CN108530424B (zh) 2021-10-01
EP3511319A1 (en) 2019-07-17
US20190002456A1 (en) 2019-01-03
CY1125127T1 (el) 2024-02-16
SMT202200136T1 (it) 2022-05-12
BR112017000043A2 (pt) 2018-07-17
KR20170018100A (ko) 2017-02-15
AU2015284383A1 (en) 2017-02-02
RS64423B1 (sr) 2023-09-29
ECSP17006821A (es) 2017-03-31
EA201891526A2 (ru) 2018-12-28
JP2017525668A (ja) 2017-09-07
EP3511319B1 (en) 2023-05-03
PT3164380T (pt) 2022-03-02
MX2017000168A (es) 2017-05-01
PL3511319T3 (pl) 2023-09-11
SA517380651B1 (ar) 2020-09-30
IL249881A0 (en) 2017-03-30

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