ES2895155T3 - Saxitoxinas modificadas en 11,13 para el tratamiento del dolor - Google Patents
Saxitoxinas modificadas en 11,13 para el tratamiento del dolor Download PDFInfo
- Publication number
- ES2895155T3 ES2895155T3 ES16785597T ES16785597T ES2895155T3 ES 2895155 T3 ES2895155 T3 ES 2895155T3 ES 16785597 T ES16785597 T ES 16785597T ES 16785597 T ES16785597 T ES 16785597T ES 2895155 T3 ES2895155 T3 ES 2895155T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- halo
- optionally substituted
- aryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(CN([C@@]1(C)[C@](C(CN(*)*(*)O)N2)NC(NO)=NC)C2=*)C1(C)O Chemical compound CC(CN([C@@]1(C)[C@](C(CN(*)*(*)O)N2)NC(NO)=NC)C2=*)C1(C)O 0.000 description 42
- VTPLNHCFGCPSAR-UHFFFAOYSA-O CC(C(CN1)N2)(NC2=[NH2+])N(C)C1=N Chemical compound CC(C(CN1)N2)(NC2=[NH2+])N(C)C1=N VTPLNHCFGCPSAR-UHFFFAOYSA-O 0.000 description 1
- PHDTZRWSGMEGDZ-CQSPOYSMSA-N CC(CC(N1C[C@@H](C(C(C2(O)O)(N3C)N4C[C@@H]2OC(c2c(C(F)(F)F)ccc(C(F)(F)F)c2)=O)NC3=N)NC4=N)=O)C1=O Chemical compound CC(CC(N1C[C@@H](C(C(C2(O)O)(N3C)N4C[C@@H]2OC(c2c(C(F)(F)F)ccc(C(F)(F)F)c2)=O)NC3=N)NC4=N)=O)C1=O PHDTZRWSGMEGDZ-CQSPOYSMSA-N 0.000 description 1
- HAPDSIPLKFRQLU-UHFFFAOYSA-N CC(CN(C(CO)(C(C(CN(C(CC1)=O)C1=O)N1)N2)NC2=N)C1=N)NC(c1c2OCCc2ccc1)=O Chemical compound CC(CN(C(CO)(C(C(CN(C(CC1)=O)C1=O)N1)N2)NC2=N)C1=N)NC(c1c2OCCc2ccc1)=O HAPDSIPLKFRQLU-UHFFFAOYSA-N 0.000 description 1
- OIYZFQLZUCFDRJ-SEDWIGOZSA-N CC(N[C@@H](CN(C1(C([C@H](CN(C(CC2)=O)C2=O)N2)NC)NC=N)C2=N)[C@H]1O)=O Chemical compound CC(N[C@@H](CN(C1(C([C@H](CN(C(CC2)=O)C2=O)N2)NC)NC=N)C2=N)[C@H]1O)=O OIYZFQLZUCFDRJ-SEDWIGOZSA-N 0.000 description 1
- MVGMZFRPBRUJAQ-UHFFFAOYSA-N CCc1cccc(C(N)=O)c1 Chemical compound CCc1cccc(C(N)=O)c1 MVGMZFRPBRUJAQ-UHFFFAOYSA-N 0.000 description 1
- MJPMFAGDBOWGDE-MLZJXEJWSA-N CN(C(CSC1)=O)/C1=[O]\N(CC(C(C1(O)O)(N2)N3C[C@@H]1OC(c1cc(C(F)(F)F)ccc1C(F)(F)F)=O)NC2=N)C3=N Chemical compound CN(C(CSC1)=O)/C1=[O]\N(CC(C(C1(O)O)(N2)N3C[C@@H]1OC(c1cc(C(F)(F)F)ccc1C(F)(F)F)=O)NC2=N)C3=N MJPMFAGDBOWGDE-MLZJXEJWSA-N 0.000 description 1
- VKPLPDIMEREJJF-UHFFFAOYSA-N COc1cccc(C(N)=O)c1 Chemical compound COc1cccc(C(N)=O)c1 VKPLPDIMEREJJF-UHFFFAOYSA-N 0.000 description 1
- GCVDGLAPBPMPCF-UHFFFAOYSA-N N/C(/c1c(C(F)(F)F)cccc1)=[O]\O[IH](CC1)(C(C(N2)=C(CN(C(CC3)=O)C3=O)N3)(NC2=N)N1C3=N)O Chemical compound N/C(/c1c(C(F)(F)F)cccc1)=[O]\O[IH](CC1)(C(C(N2)=C(CN(C(CC3)=O)C3=O)N3)(NC2=N)N1C3=N)O GCVDGLAPBPMPCF-UHFFFAOYSA-N 0.000 description 1
- DXBQJUMPQKYUJH-BUDIUTNSSA-O N=C(NC(CN(C(CC1)=O)C1=O)C1N2)N(CCC3(O)O)[C@]13NC2=[NH2+] Chemical compound N=C(NC(CN(C(CC1)=O)C1=O)C1N2)N(CCC3(O)O)[C@]13NC2=[NH2+] DXBQJUMPQKYUJH-BUDIUTNSSA-O 0.000 description 1
- UIKVTAQNLSTGEK-GKATWMMFSA-N N=C(NC1C(CN(C(CC2)=O)C2=O)N2)NC1(C([C@H](C1)NC(CCc3cc(C(F)(F)F)ccc3)=O)O)N1C2=N Chemical compound N=C(NC1C(CN(C(CC2)=O)C2=O)N2)NC1(C([C@H](C1)NC(CCc3cc(C(F)(F)F)ccc3)=O)O)N1C2=N UIKVTAQNLSTGEK-GKATWMMFSA-N 0.000 description 1
- ZATPEWPZGBPZMC-DDSVBCIISA-N N=C(NC1[C@H](CN(C(CC2)=O)C2=O)N2)NC1(C(CO)[C@H](C1)OC(NCC(c3ccccc3)c3ccccc3)=O)N1C2=N Chemical compound N=C(NC1[C@H](CN(C(CC2)=O)C2=O)N2)NC1(C(CO)[C@H](C1)OC(NCC(c3ccccc3)c3ccccc3)=O)N1C2=N ZATPEWPZGBPZMC-DDSVBCIISA-N 0.000 description 1
- JXLHSFCJNUDCLK-ZLWAWHNYSA-N N=C(NC1[C@H](CN(C(CC2)=O)C2=O)N2)N[C@@]1(C([C@H](C1)NC(C3(CC3)C(F)(F)F)=O)(O)O)N1C2=N Chemical compound N=C(NC1[C@H](CN(C(CC2)=O)C2=O)N2)N[C@@]1(C([C@H](C1)NC(C3(CC3)C(F)(F)F)=O)(O)O)N1C2=N JXLHSFCJNUDCLK-ZLWAWHNYSA-N 0.000 description 1
- DFKBQZSRDIXJCA-WXFXRELQSA-N N=C(NC1[C@H](CN(C(CC2)=O)C2=O)N2)N[C@@]1([C@@](C(C1)NC(c3cccc(C(F)(F)F)c3)=O)(C=O)O)N1C2=N Chemical compound N=C(NC1[C@H](CN(C(CC2)=O)C2=O)N2)N[C@@]1([C@@](C(C1)NC(c3cccc(C(F)(F)F)c3)=O)(C=O)O)N1C2=N DFKBQZSRDIXJCA-WXFXRELQSA-N 0.000 description 1
- SPCKTUAGGFSMCU-MIPJLZMMSA-N N=C(N[C@H]1C(CN(C(CS2)=O)C2=O)N2)NC1(C([C@H](C1)OC(c3c(C(F)(F)F)ccc(C(F)(F)F)c3)=O)(O)O)N1C2=N Chemical compound N=C(N[C@H]1C(CN(C(CS2)=O)C2=O)N2)NC1(C([C@H](C1)OC(c3c(C(F)(F)F)ccc(C(F)(F)F)c3)=O)(O)O)N1C2=N SPCKTUAGGFSMCU-MIPJLZMMSA-N 0.000 description 1
- VDTLXNYEVYMEOM-LRLVSMCWSA-N N=C1N(C[C@@H](C2O)OC(NC(c3ccccc3)c3ccccc3)=O)C22NCNC2C(CN(C(CC2)=O)C2=O)N1 Chemical compound N=C1N(C[C@@H](C2O)OC(NC(c3ccccc3)c3ccccc3)=O)C22NCNC2C(CN(C(CC2)=O)C2=O)N1 VDTLXNYEVYMEOM-LRLVSMCWSA-N 0.000 description 1
- GRNXTUOKSPKJPC-UHFFFAOYSA-P [NH3+]C(NC1C(CN(C(CC2)=O)C2=O)N2)NC1(C(CC1)(O)O)N1C2=[NH2+] Chemical compound [NH3+]C(NC1C(CN(C(CC2)=O)C2=O)N2)NC1(C(CC1)(O)O)N1C2=[NH2+] GRNXTUOKSPKJPC-UHFFFAOYSA-P 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235412P | 2015-09-30 | 2015-09-30 | |
| PCT/US2016/055050 WO2017059385A1 (en) | 2015-09-30 | 2016-09-30 | 11,13-modified saxitoxins for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2895155T3 true ES2895155T3 (es) | 2022-02-17 |
Family
ID=57200084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16785597T Active ES2895155T3 (es) | 2015-09-30 | 2016-09-30 | Saxitoxinas modificadas en 11,13 para el tratamiento del dolor |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10112953B2 (enExample) |
| EP (1) | EP3356370B1 (enExample) |
| JP (1) | JP2018534270A (enExample) |
| CN (1) | CN108473503A (enExample) |
| AU (1) | AU2016329201A1 (enExample) |
| CA (1) | CA3000708A1 (enExample) |
| ES (1) | ES2895155T3 (enExample) |
| IL (1) | IL258471A (enExample) |
| WO (1) | WO2017059385A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2944549A1 (en) | 2014-04-09 | 2015-10-15 | Siteone Therapeutics, Inc. | 10',11'-modified saxitoxin useful for the treatment of pain |
| AU2018243463C1 (en) * | 2017-03-29 | 2022-12-01 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
| WO2018183782A1 (en) | 2017-03-29 | 2018-10-04 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
| WO2020072835A1 (en) * | 2018-10-03 | 2020-04-09 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| US20230339958A1 (en) * | 2020-08-14 | 2023-10-26 | Siteone Therapeutics, Inc. | Non-hydrated ketone inhibitors of nav1.7 for the treatment of pain |
| WO2022256676A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| JP2024520648A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルの調節因子としての置換テトラヒドロフラン－２－カルボキサミド |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| US20240400544A1 (en) | 2021-06-04 | 2024-12-05 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| WO2022256842A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| BR112023025264A2 (pt) | 2021-06-04 | 2024-02-20 | Vertex Pharma | Formas farmacêuticas sólidas e regimes posológicos compreendendo (2r,3s,4s,5r)-4-[[3- (3,4-difluoro-2-metóxi-fenil)-4,5-dimetil-5-(trifluorometil) tetra-hidrofuran-2-carbonil]amino ]piridina-2-carboxamida |
| CN113943243B (zh) * | 2021-10-14 | 2023-08-01 | 南开大学 | 一种用于同时鉴定和定量氨基酸的氟探针的制备与应用 |
| EP4511117A1 (en) | 2022-04-22 | 2025-02-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CA3256604A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | HETEROARYL COMPOUNDS FOR PAIN RELIEF |
| JP2025513454A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| GEAP202516632A (en) | 2022-04-22 | 2025-02-25 | Vertex Pharma | Heteroaryl compounds for the treatment of pain |
| CN120603815A (zh) | 2022-12-06 | 2025-09-05 | 沃泰克斯药物股份有限公司 | 钠通道的取代四氢呋喃调节剂的合成方法 |
| WO2025090465A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090516A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing compounds for treating pain and solid forms thereof |
| TW202535867A (zh) | 2023-10-23 | 2025-09-16 | 美商維泰克斯製藥公司 | 用於治療疼痛之鈉通道調節劑及其固體形式的製備方法 |
| US20250186419A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens for treating pain |
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| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| WO1997001331A2 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
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-
2016
- 2016-09-30 US US15/283,187 patent/US10112953B2/en active Active
- 2016-09-30 WO PCT/US2016/055050 patent/WO2017059385A1/en not_active Ceased
- 2016-09-30 CN CN201680068998.6A patent/CN108473503A/zh active Pending
- 2016-09-30 JP JP2018517286A patent/JP2018534270A/ja not_active Withdrawn
- 2016-09-30 EP EP16785597.2A patent/EP3356370B1/en active Active
- 2016-09-30 ES ES16785597T patent/ES2895155T3/es active Active
- 2016-09-30 AU AU2016329201A patent/AU2016329201A1/en not_active Abandoned
- 2016-09-30 CA CA3000708A patent/CA3000708A1/en not_active Abandoned
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2018
- 2018-03-29 IL IL258471A patent/IL258471A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017059385A8 (en) | 2017-11-02 |
| US10112953B2 (en) | 2018-10-30 |
| WO2017059385A1 (en) | 2017-04-06 |
| AU2016329201A1 (en) | 2018-04-26 |
| AU2016329201A8 (en) | 2018-05-17 |
| JP2018534270A (ja) | 2018-11-22 |
| CA3000708A1 (en) | 2017-04-06 |
| US20170233398A1 (en) | 2017-08-17 |
| IL258471A (en) | 2018-05-31 |
| CN108473503A (zh) | 2018-08-31 |
| EP3356370A1 (en) | 2018-08-08 |
| EP3356370B1 (en) | 2021-08-18 |
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