ES2871052T3 - Inhibidores tricíclicos de la poli(ADP-ribosa)polimerasa - Google Patents
Inhibidores tricíclicos de la poli(ADP-ribosa)polimerasa Download PDFInfo
- Publication number
- ES2871052T3 ES2871052T3 ES12792550T ES12792550T ES2871052T3 ES 2871052 T3 ES2871052 T3 ES 2871052T3 ES 12792550 T ES12792550 T ES 12792550T ES 12792550 T ES12792550 T ES 12792550T ES 2871052 T3 ES2871052 T3 ES 2871052T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- unsubstituted
- oxide
- azaphosphinan
- phthalazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(C1)NCCP1(*)=* Chemical compound CC(C1)NCCP1(*)=* 0.000 description 7
- KNHJLNSESCKUKI-UHFFFAOYSA-N COC(c(cc(cc1)F)c1C#Cc(cc1Br)ccc1F)=O Chemical compound COC(c(cc(cc1)F)c1C#Cc(cc1Br)ccc1F)=O KNHJLNSESCKUKI-UHFFFAOYSA-N 0.000 description 1
- BRUNIDAHRLZQOH-UHFFFAOYSA-N COC(c(cc(cc1)F)c1I)=O Chemical compound COC(c(cc(cc1)F)c1I)=O BRUNIDAHRLZQOH-UHFFFAOYSA-N 0.000 description 1
- RDXMKIOPAQRRKQ-UHFFFAOYSA-N O=C(c1c2)NN=C(Cc(cc3P4(CCN(Cc5ccccc5)CC4)=O)ccc3F)c1ccc2F Chemical compound O=C(c1c2)NN=C(Cc(cc3P4(CCN(Cc5ccccc5)CC4)=O)ccc3F)c1ccc2F RDXMKIOPAQRRKQ-UHFFFAOYSA-N 0.000 description 1
- NYSJHCBHBQAYFX-UHFFFAOYSA-N O=C1NN=C(Cc(cc2)cc(P(CC3)(CCN3C3CC3)=O)c2F)c(cc2)c1cc2F Chemical compound O=C1NN=C(Cc(cc2)cc(P(CC3)(CCN3C3CC3)=O)c2F)c(cc2)c1cc2F NYSJHCBHBQAYFX-UHFFFAOYSA-N 0.000 description 1
- LXPAEQXCSCAYJX-UHFFFAOYSA-N O=C1NN=C(Cc(cc2)cc(P3(CCN(CC(F)(F)F)CC3)=O)c2F)c2ccccc12 Chemical compound O=C1NN=C(Cc(cc2)cc(P3(CCN(CC(F)(F)F)CC3)=O)c2F)c2ccccc12 LXPAEQXCSCAYJX-UHFFFAOYSA-N 0.000 description 1
- NKWRNNXACOVHNK-UHFFFAOYSA-N O=C1NN=C(Cc(cc2Br)ccc2F)c(cc2)c1cc2F Chemical compound O=C1NN=C(Cc(cc2Br)ccc2F)c(cc2)c1cc2F NKWRNNXACOVHNK-UHFFFAOYSA-N 0.000 description 1
- KUDVXLARCFBRBX-UHFFFAOYSA-N O=C1NN=C(Cc(cc2P3(CCNCC3)=O)ccc2F)c(cc2)c1cc2F Chemical compound O=C1NN=C(Cc(cc2P3(CCNCC3)=O)ccc2F)c(cc2)c1cc2F KUDVXLARCFBRBX-UHFFFAOYSA-N 0.000 description 1
- BRATYQVOINPFFS-UHFFFAOYSA-N O=C1NN=C(Cc(cc2P3(CCNCC3)=O)ccc2F)c2ccccc12 Chemical compound O=C1NN=C(Cc(cc2P3(CCNCC3)=O)ccc2F)c2ccccc12 BRATYQVOINPFFS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161491851P | 2011-05-31 | 2011-05-31 | |
| PCT/US2012/040304 WO2012166983A1 (en) | 2011-05-31 | 2012-05-31 | Tricyclic inhibitors of poly(adp-ribose)polymerase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2871052T3 true ES2871052T3 (es) | 2021-10-28 |
Family
ID=47259874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12792550T Active ES2871052T3 (es) | 2011-05-31 | 2012-05-31 | Inhibidores tricíclicos de la poli(ADP-ribosa)polimerasa |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20140221314A1 (enExample) |
| EP (2) | EP2714703B1 (enExample) |
| JP (1) | JP5960253B2 (enExample) |
| CN (1) | CN103717609B (enExample) |
| CA (1) | CA2875025C (enExample) |
| ES (1) | ES2871052T3 (enExample) |
| TW (1) | TWI577693B (enExample) |
| WO (1) | WO2012166983A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI577693B (zh) | 2011-05-31 | 2017-04-11 | 江蘇康緣藥業股份有限公司 | 聚（ａｄｐ-核糖）聚合酶之三環抑制劑 |
| MX2015006780A (es) | 2012-12-31 | 2015-08-06 | Cadila Healthcare Ltd | Derivados de ftalazin-1-(2h)-ona sustituida. |
| WO2016187620A2 (en) | 2015-05-21 | 2016-11-24 | The Regents Of The University Of California | Anti-cancer compounds |
| MX387726B (es) | 2016-06-24 | 2025-03-18 | Univ California | Derivados de ftalazina como inhibidores de parp1, parp2 y/o tubulina útiles para el tratamiento del cáncer. |
| CA3095709A1 (en) * | 2018-04-05 | 2019-10-10 | Noviga Research Ab | Novel combinations of a tubulin polymerization inhibitor and a poly (adp-ribose) polymerase (parp) inhibitor for use in the treatment of cancer |
| AU2020328598B2 (en) | 2019-08-15 | 2026-07-02 | Black Diamond Therapeutics, Inc. | Alkynyl quinazoline compounds |
| CN112574122B (zh) * | 2019-09-27 | 2024-05-31 | 上海天慈国际药业有限公司 | 一种奥拉帕尼关键中间体的制备方法 |
| CN114276301B (zh) * | 2020-09-27 | 2025-04-01 | 江西科睿药业有限公司 | Parp抑制剂的中间体化合物及其制备方法和应用 |
| CN112624981B (zh) * | 2021-03-09 | 2021-05-25 | 南京桦冠生物技术有限公司 | 一种2-氟-5-[(4-氧代-3h-2,3-二氮杂萘基)甲基]苯甲酸的制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59609305D1 (de) | 1995-11-17 | 2002-07-11 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Herstellung |
| EP1386922B1 (en) | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| JP2002536968A (ja) | 1999-01-29 | 2002-11-05 | イムクローン システムズ インコーポレイティド | Ｋｄｒに特異的な抗体およびその使用 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| EP1187633A4 (en) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY |
| US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| HU228960B1 (hu) | 2000-10-30 | 2013-07-29 | Kudos Pharm Ltd | Ftalazinon-származékok |
| KR100663147B1 (ko) | 2002-02-19 | 2007-02-28 | 오노 야꾸힝 고교 가부시키가이샤 | 축합 피리다진 유도체 화합물 및 이를 유효 성분으로서함유하는 약제 |
| DE60335359D1 (de) | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| US7223749B2 (en) | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| PL1633724T3 (pl) * | 2003-03-12 | 2011-10-31 | Kudos Pharm Ltd | Pochodne ftalazynonu |
| KR20070057859A (ko) * | 2004-08-26 | 2007-06-07 | 쿠도스 파마슈티칼스 리미티드 | 4-헤테로아릴메틸 치환된 프탈라지논 유도체 |
| GB0419072D0 (en) * | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| JP2009544611A (ja) * | 2006-07-20 | 2009-12-17 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 |
| MX347085B (es) | 2006-12-28 | 2017-04-06 | Abbott Laboratories * | Inhibidores de la poli (adp-ribosa) polimerasa. |
| US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| US20080280910A1 (en) | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
| TW200900396A (en) | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US20090023727A1 (en) | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| WO2009034326A1 (en) | 2007-09-14 | 2009-03-19 | Astrazeneca Ab | Phthalazinone derivatives |
| MX2010004028A (es) * | 2007-10-17 | 2010-04-30 | Kudos Pharm Ltd | 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona. |
| JP5758630B2 (ja) | 2007-11-15 | 2015-08-05 | エンメエッセディ・イタリア・エッセ・エッレ・エッレ | Ｐａｒｐ阻害剤としてのピリダジノン誘導体 |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| JP2011523646A (ja) * | 2008-05-21 | 2011-08-18 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのリン誘導体 |
| WO2010141796A2 (en) * | 2009-06-05 | 2010-12-09 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES |
| CA2804190A1 (en) | 2009-07-02 | 2011-01-06 | Newgen Therapeutics, Inc. | Phosphorus containing quinazoline compounds and methods of use |
| TWI577693B (zh) | 2011-05-31 | 2017-04-11 | 江蘇康緣藥業股份有限公司 | 聚（ａｄｐ-核糖）聚合酶之三環抑制劑 |
-
2012
- 2012-05-31 TW TW101119653A patent/TWI577693B/zh active
- 2012-05-31 EP EP12792550.1A patent/EP2714703B1/en active Active
- 2012-05-31 CA CA2875025A patent/CA2875025C/en active Active
- 2012-05-31 WO PCT/US2012/040304 patent/WO2012166983A1/en not_active Ceased
- 2012-05-31 US US14/122,983 patent/US20140221314A1/en not_active Abandoned
- 2012-05-31 ES ES12792550T patent/ES2871052T3/es active Active
- 2012-05-31 CN CN201280024255.0A patent/CN103717609B/zh active Active
- 2012-05-31 EP EP21161257.7A patent/EP3925962A1/en not_active Withdrawn
- 2012-05-31 JP JP2014513717A patent/JP5960253B2/ja active Active
-
2016
- 2016-04-01 US US15/089,131 patent/US20170057984A1/en not_active Abandoned
-
2017
- 2017-06-15 US US15/624,201 patent/US20180094010A1/en not_active Abandoned
-
2019
- 2019-10-28 US US16/666,307 patent/US11248013B2/en active Active
-
2022
- 2022-02-14 US US17/671,436 patent/US12612425B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180094010A1 (en) | 2018-04-05 |
| CA2875025C (en) | 2021-08-03 |
| JP5960253B2 (ja) | 2016-08-02 |
| EP2714703B1 (en) | 2021-03-10 |
| TWI577693B (zh) | 2017-04-11 |
| CN103717609B (zh) | 2016-05-11 |
| TW201311713A (zh) | 2013-03-16 |
| US20170057984A1 (en) | 2017-03-02 |
| US20230027257A1 (en) | 2023-01-26 |
| EP3925962A1 (en) | 2021-12-22 |
| CA2875025A1 (en) | 2012-12-06 |
| US12612425B2 (en) | 2026-04-28 |
| JP2014516989A (ja) | 2014-07-17 |
| US20140221314A1 (en) | 2014-08-07 |
| EP2714703A1 (en) | 2014-04-09 |
| US11248013B2 (en) | 2022-02-15 |
| WO2012166983A1 (en) | 2012-12-06 |
| US20200299315A1 (en) | 2020-09-24 |
| EP2714703A4 (en) | 2014-12-31 |
| CN103717609A (zh) | 2014-04-09 |
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