ES2865196T3 - Anticuerpos anti-HER3 humana alostéricos de neuregulina - Google Patents
Anticuerpos anti-HER3 humana alostéricos de neuregulina Download PDFInfo
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- ES2865196T3 ES2865196T3 ES13834359T ES13834359T ES2865196T3 ES 2865196 T3 ES2865196 T3 ES 2865196T3 ES 13834359 T ES13834359 T ES 13834359T ES 13834359 T ES13834359 T ES 13834359T ES 2865196 T3 ES2865196 T3 ES 2865196T3
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2013/002733 WO2015067986A1 (en) | 2013-11-07 | 2013-11-07 | Neuregulin allosteric anti-her3 antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2865196T3 true ES2865196T3 (es) | 2021-10-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13834359T Active ES2865196T3 (es) | 2013-11-07 | 2013-11-07 | Anticuerpos anti-HER3 humana alostéricos de neuregulina |
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| Country | Link |
|---|---|
| US (1) | US10196455B2 (enExample) |
| EP (1) | EP3066124B1 (enExample) |
| JP (1) | JP6449876B2 (enExample) |
| KR (1) | KR20160101909A (enExample) |
| CN (1) | CN105849125B (enExample) |
| BR (1) | BR112016010336A2 (enExample) |
| CA (1) | CA2929386C (enExample) |
| ES (1) | ES2865196T3 (enExample) |
| MX (1) | MX2016005854A (enExample) |
| PL (1) | PL3066124T4 (enExample) |
| RU (1) | RU2704228C2 (enExample) |
| WO (1) | WO2015067986A1 (enExample) |
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| EP3091033A1 (en) * | 2015-05-06 | 2016-11-09 | Gamamabs Pharma | Anti-human-her3 antibodies and uses thereof |
| TW201716439A (zh) | 2015-07-20 | 2017-05-16 | 美國禮來大藥廠 | Ｈｅｒ３抗體 |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| KR20200031571A (ko) * | 2017-05-29 | 2020-03-24 | 가마맵스 파마 | 암 연관 면역억제의 억제제 |
| US11046741B2 (en) * | 2018-04-11 | 2021-06-29 | Salubris Biotherapeutics, Inc. | Human neuregulin-1 (NRG-1) recombinant fusion protein compositions and methods of use thereof |
Family Cites Families (74)
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| US4486414A (en) | 1983-03-21 | 1984-12-04 | Arizona Board Of Reagents | Dolastatins A and B cell growth inhibitory substances |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| AU606320B2 (en) | 1985-11-01 | 1991-02-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US4816444A (en) | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
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-
2013
- 2013-11-07 KR KR1020167015132A patent/KR20160101909A/ko not_active Ceased
- 2013-11-07 ES ES13834359T patent/ES2865196T3/es active Active
- 2013-11-07 PL PL13834359T patent/PL3066124T4/pl unknown
- 2013-11-07 BR BR112016010336A patent/BR112016010336A2/pt not_active IP Right Cessation
- 2013-11-07 RU RU2016121542A patent/RU2704228C2/ru active
- 2013-11-07 JP JP2016528182A patent/JP6449876B2/ja not_active Expired - Fee Related
- 2013-11-07 WO PCT/IB2013/002733 patent/WO2015067986A1/en not_active Ceased
- 2013-11-07 EP EP13834359.5A patent/EP3066124B1/en active Active
- 2013-11-07 US US15/035,129 patent/US10196455B2/en active Active
- 2013-11-07 MX MX2016005854A patent/MX2016005854A/es unknown
- 2013-11-07 CN CN201380081577.3A patent/CN105849125B/zh not_active Expired - Fee Related
- 2013-11-07 CA CA2929386A patent/CA2929386C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016121542A (ru) | 2017-12-12 |
| RU2704228C2 (ru) | 2019-10-24 |
| CA2929386A1 (en) | 2015-05-14 |
| CN105849125A (zh) | 2016-08-10 |
| US10196455B2 (en) | 2019-02-05 |
| WO2015067986A1 (en) | 2015-05-14 |
| EP3066124A1 (en) | 2016-09-14 |
| PL3066124T3 (pl) | 2021-08-16 |
| CN105849125B (zh) | 2020-05-15 |
| BR112016010336A2 (pt) | 2017-10-03 |
| MX2016005854A (es) | 2017-07-28 |
| PL3066124T4 (pl) | 2021-08-16 |
| JP2016536988A (ja) | 2016-12-01 |
| KR20160101909A (ko) | 2016-08-26 |
| US20160319033A1 (en) | 2016-11-03 |
| CA2929386C (en) | 2023-01-03 |
| JP6449876B2 (ja) | 2019-01-09 |
| EP3066124B1 (en) | 2021-01-06 |
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