ES2847929T3 - Tratamiento de la demencia - Google Patents

Tratamiento de la demencia Download PDF

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Publication number
ES2847929T3
ES2847929T3 ES17761842T ES17761842T ES2847929T3 ES 2847929 T3 ES2847929 T3 ES 2847929T3 ES 17761842 T ES17761842 T ES 17761842T ES 17761842 T ES17761842 T ES 17761842T ES 2847929 T3 ES2847929 T3 ES 2847929T3
Authority
ES
Spain
Prior art keywords
compound
subject
treatment
ftld
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17761842T
Other languages
English (en)
Spanish (es)
Inventor
Claude Michel Wischik
Björn Olaf Schelter
Damon Jude Wischik
John Mervyn David Storey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wista Laboratories Ltd
Original Assignee
Wista Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Laboratories Ltd filed Critical Wista Laboratories Ltd
Application granted granted Critical
Publication of ES2847929T3 publication Critical patent/ES2847929T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Valve Device For Special Equipments (AREA)
ES17761842T 2016-09-01 2017-08-25 Tratamiento de la demencia Active ES2847929T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1614834.8A GB201614834D0 (en) 2016-09-01 2016-09-01 Treatment of dementia
PCT/EP2017/071437 WO2018041739A1 (en) 2016-09-01 2017-08-25 Treatment of dementia

Publications (1)

Publication Number Publication Date
ES2847929T3 true ES2847929T3 (es) 2021-08-04

Family

ID=57139937

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17761842T Active ES2847929T3 (es) 2016-09-01 2017-08-25 Tratamiento de la demencia

Country Status (18)

Country Link
US (1) US10842796B2 (cg-RX-API-DMAC7.html)
EP (1) EP3506904B1 (cg-RX-API-DMAC7.html)
JP (1) JP7066679B2 (cg-RX-API-DMAC7.html)
KR (1) KR102559354B1 (cg-RX-API-DMAC7.html)
CN (1) CN109890391B (cg-RX-API-DMAC7.html)
AU (1) AU2017318333B2 (cg-RX-API-DMAC7.html)
CA (1) CA3034625A1 (cg-RX-API-DMAC7.html)
DK (1) DK3506904T3 (cg-RX-API-DMAC7.html)
ES (1) ES2847929T3 (cg-RX-API-DMAC7.html)
GB (1) GB201614834D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20210162T1 (cg-RX-API-DMAC7.html)
MX (1) MX384442B (cg-RX-API-DMAC7.html)
MY (1) MY187564A (cg-RX-API-DMAC7.html)
PL (1) PL3506904T3 (cg-RX-API-DMAC7.html)
PT (1) PT3506904T (cg-RX-API-DMAC7.html)
SG (1) SG11201901125TA (cg-RX-API-DMAC7.html)
SI (1) SI3506904T1 (cg-RX-API-DMAC7.html)
WO (1) WO2018041739A1 (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104529939B (zh) 2006-03-29 2019-05-07 维斯塔实验室有限公司 3,7-二氨基-10h-吩噻嗪化合物盐及其用途
PT2057136E (pt) 2006-07-11 2013-08-28 Wista Lab Ltd Processos de síntese e/ou purificação de compostos diaminofenotiazínio
EP3487505B1 (en) 2016-07-25 2023-05-03 WisTa Laboratories Ltd. Administration and dosage of diaminophenothiazines
MX2021000894A (es) * 2018-07-26 2021-03-31 Wista Lab Ltd Dosificacion optimizada de diaminofenotiazinas en poblaciones.
JP7401531B2 (ja) 2018-09-05 2023-12-19 ゲンティング タークス ダイアグノースティク センター エスディエヌ ビーエイチディ 神経変性疾患のためのネットワーク法
GB201909493D0 (en) * 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909454D0 (en) * 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
AU2021268465A1 (en) * 2020-05-05 2022-12-08 TauRx Therapeutics Management Ltd Methylthioninium compounds for use in the treatment of hypoxemia
GB202006659D0 (en) * 2020-05-05 2020-06-17 Wista Lab Ltd Therapeutic treatments
CA3257856A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. TREATMENT OF NEURODEGENERATIVE DISORDERS USING COMPOUNDS CONTAINING METHYLTHIONINIUM (MT)
EP4342451A1 (en) * 2022-09-22 2024-03-27 Galenicum Health SLU Pharmaceutical compositions and manufacturing methods thereof
US20240115579A1 (en) * 2022-09-22 2024-04-11 Galenicum Health S.L.U. Pharmaceutical compositions and manufacturing methods thereof
US20240300940A1 (en) * 2023-02-21 2024-09-12 Prosetta Biosciences, Inc. Phenothiazinyl Compounds and Uses

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
DE60324788D1 (de) * 2002-05-31 2009-01-02 Lundbeck & Co As H Kombination aus einem nmda-antagonist und acetylcholinesterase-hemmern zur behandlung der alzheimer-krankheit
PL2322517T3 (pl) 2004-09-23 2019-09-30 Wista Laboratories Ltd. Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazyniowych, w tym chlorku metylotioniny (MTC)
EP2853293B1 (en) * 2006-03-29 2017-11-22 WisTa Laboratories Ltd. Thioninium compounds and their use
CN104529939B (zh) 2006-03-29 2019-05-07 维斯塔实验室有限公司 3,7-二氨基-10h-吩噻嗪化合物盐及其用途
FR2899107B1 (fr) * 2006-03-30 2008-06-13 Neurokin Entpr Unipersonnelle Utilisation de la (s)-roscovitine pour la fabrication d'un medicament
PT2057136E (pt) 2006-07-11 2013-08-28 Wista Lab Ltd Processos de síntese e/ou purificação de compostos diaminofenotiazínio
FR2903696B1 (fr) 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
US9034890B2 (en) * 2006-11-15 2015-05-19 Steven A. Rich Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases
PL2167095T3 (pl) * 2007-06-19 2019-11-29 Wista Lab Ltd Związki fenotiazynowe do leczenia łagodnych zaburzeń poznawczych
CA2701075C (en) 2007-10-03 2019-02-12 Wista Laboratories Ltd. Therapeutic use of diaminophenothiazines.
PT3792254T (pt) 2009-09-24 2023-10-19 Wista Lab Ltd Hidratos de cloreto de metiltionínio cristalino
MY161463A (en) 2009-09-24 2017-04-14 Wista Lab Ltd Process for the preparation of substantially pure methylthionium chloride pentahydrate form a
JP5898701B2 (ja) * 2011-02-11 2016-04-13 ウィスタ ラボラトリーズ リミテッド フェノチアジンジアミニウム塩およびそれらの使用
CN102936244B (zh) * 2012-12-04 2015-02-04 合肥工业大学 一种他克林-吩噻嗪异二联体类化合物及其制备方法

Also Published As

Publication number Publication date
EP3506904B1 (en) 2020-12-09
SG11201901125TA (en) 2019-03-28
EP3506904A1 (en) 2019-07-10
CN109890391A (zh) 2019-06-14
SI3506904T1 (sl) 2021-03-31
DK3506904T3 (da) 2021-01-04
CA3034625A1 (en) 2018-03-08
CN109890391B (zh) 2023-01-31
HRP20210162T1 (hr) 2021-03-19
PL3506904T3 (pl) 2021-07-26
KR20190045273A (ko) 2019-05-02
MY187564A (en) 2021-09-30
KR102559354B1 (ko) 2023-07-26
PT3506904T (pt) 2021-02-02
JP2019526571A (ja) 2019-09-19
WO2018041739A1 (en) 2018-03-08
JP7066679B2 (ja) 2022-05-13
MX2019002429A (es) 2019-07-08
AU2017318333A1 (en) 2019-04-18
GB201614834D0 (en) 2016-10-19
US10842796B2 (en) 2020-11-24
AU2017318333B2 (en) 2023-05-11
MX384442B (es) 2025-03-14
US20190192530A1 (en) 2019-06-27

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