ES2841452T3 - Macrociclos de piridazinona como inhibidores de IRAK y sus usos - Google Patents
Macrociclos de piridazinona como inhibidores de IRAK y sus usos Download PDFInfo
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- ES2841452T3 ES2841452T3 ES16706471T ES16706471T ES2841452T3 ES 2841452 T3 ES2841452 T3 ES 2841452T3 ES 16706471 T ES16706471 T ES 16706471T ES 16706471 T ES16706471 T ES 16706471T ES 2841452 T3 ES2841452 T3 ES 2841452T3
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Classifications
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562112793P | 2015-02-06 | 2015-02-06 | |
| PCT/US2016/016708 WO2016127024A1 (en) | 2015-02-06 | 2016-02-05 | Pyridazinone macrocycles as irak inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2841452T3 true ES2841452T3 (es) | 2021-07-08 |
Family
ID=55436166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16706471T Active ES2841452T3 (es) | 2015-02-06 | 2016-02-05 | Macrociclos de piridazinona como inhibidores de IRAK y sus usos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9624246B2 (OSRAM) |
| EP (1) | EP3253763B1 (OSRAM) |
| JP (1) | JP6920202B2 (OSRAM) |
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Families Citing this family (14)
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| ES2841452T3 (es) * | 2015-02-06 | 2021-07-08 | Merck Patent Gmbh | Macrociclos de piridazinona como inhibidores de IRAK y sus usos |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI733982B (zh) | 2017-02-16 | 2021-07-21 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒衍生物 |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| WO2019120267A1 (zh) * | 2017-12-22 | 2019-06-27 | 成都先导药物开发股份有限公司 | 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂 |
| MX2020009234A (es) * | 2018-04-05 | 2020-10-12 | Merck Patent Gmbh | Compuestos de heteroarilo como inhibidores de cinasas asociadas con receptores de interleucina-1 (irak) tipo ii y usos de los mismos. |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| JP7164705B2 (ja) | 2018-08-13 | 2022-11-01 | ギリアード サイエンシーズ， インコーポレイテッド | ＩＲＡＫ４阻害剤としてのピロロ［１，２－ｂ］ピリダジン誘導体 |
| US11572362B2 (en) | 2018-08-13 | 2023-02-07 | Gilead Sciences, Inc. | Pyrrolo[1,2-b]pyridazine derivatives |
| TWI727392B (zh) | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| US11998534B2 (en) * | 2020-02-12 | 2024-06-04 | Eubulus Biotherapeutics Inc. | GPX4 inhibitor in combination with anticancer agent for treating proliferative disease |
| CN111603471B (zh) * | 2020-06-24 | 2021-07-09 | 山东省科学院生物研究所 | 一种邻二氮杂环化合物在制备抑制tlr4受体的药物中的用途 |
| EP4223368B1 (en) | 2020-09-30 | 2025-05-21 | Asahi Kasei Pharma Corporation | Macrocyclic compounds incorporating piperidine and quinoline or qunaxoline as irak-4 inhibitors for the treatment of inflammatory conditions |
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| JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−３−オン誘導体及びこれを含有する医薬 |
| JP2010138073A (ja) * | 2007-03-30 | 2010-06-24 | Taisho Pharmaceutical Co Ltd | ピコリン酸アミド化合物 |
| US8703768B2 (en) * | 2010-06-09 | 2014-04-22 | Hoffmann-La Roche Inc. | Nitrogen containing heteroaryl compounds |
| US9586948B2 (en) * | 2012-10-08 | 2017-03-07 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| RU2660435C2 (ru) * | 2013-02-07 | 2018-07-06 | Мерк Патент Гмбх | Макроциклические производные пиридазинона |
| HUE032863T2 (en) * | 2013-02-07 | 2017-11-28 | Merck Patent Gmbh | Piridazinonamid derivatives |
| ES2841452T3 (es) * | 2015-02-06 | 2021-07-08 | Merck Patent Gmbh | Macrociclos de piridazinona como inhibidores de IRAK y sus usos |
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| JP6920202B2 (ja) | 2021-08-18 |
| BR112017014970A2 (pt) | 2018-03-27 |
| AU2016215184B2 (en) | 2020-11-12 |
| AU2016215184A1 (en) | 2017-06-29 |
| IL253519B (en) | 2021-01-31 |
| IL253519A0 (en) | 2017-09-28 |
| RU2708066C2 (ru) | 2019-12-04 |
| MX2017009624A (es) | 2017-11-20 |
| US20160229871A1 (en) | 2016-08-11 |
| KR102551597B1 (ko) | 2023-07-05 |
| NZ732527A (en) | 2022-03-25 |
| KR20170113551A (ko) | 2017-10-12 |
| RU2017130761A3 (OSRAM) | 2019-07-17 |
| RU2017130761A (ru) | 2019-03-06 |
| MX380929B (es) | 2025-03-12 |
| JP2018505166A (ja) | 2018-02-22 |
| CN107428765B (zh) | 2020-12-29 |
| WO2016127024A1 (en) | 2016-08-11 |
| BR112017014970B1 (pt) | 2022-11-16 |
| CA2970550C (en) | 2023-09-19 |
| US20170173019A1 (en) | 2017-06-22 |
| EP3253763A1 (en) | 2017-12-13 |
| US9624246B2 (en) | 2017-04-18 |
| HK1246287A1 (zh) | 2018-09-07 |
| CA2970550A1 (en) | 2016-08-11 |
| EP3253763B1 (en) | 2020-09-30 |
| SG11201704651UA (en) | 2017-07-28 |
| CN107428765A (zh) | 2017-12-01 |
| US10517872B2 (en) | 2019-12-31 |
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