RU2708066C2 - Макроциклы пиридазинона в качестве ингибиторов irak-киназы и их применения - Google Patents

Макроциклы пиридазинона в качестве ингибиторов irak-киназы и их применения Download PDF

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RU2708066C2
RU2708066C2 RU2017130761A RU2017130761A RU2708066C2 RU 2708066 C2 RU2708066 C2 RU 2708066C2 RU 2017130761 A RU2017130761 A RU 2017130761A RU 2017130761 A RU2017130761 A RU 2017130761A RU 2708066 C2 RU2708066 C2 RU 2708066C2
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compound
kinase
compounds
pharmaceutically acceptable
mmol
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RU2017130761A
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RU2017130761A3 (OSRAM
RU2017130761A (ru
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Сяолин Чэнь
Жоси ЛАНЬ
Кэтрин ЖОРАН-ЛЕБРЕН
Генри Юй
Андреас Гоутопоулос
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Мерк Патент Гмбх
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
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RU2017130761A 2015-02-06 2016-02-05 Макроциклы пиридазинона в качестве ингибиторов irak-киназы и их применения RU2708066C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112793P 2015-02-06 2015-02-06
US62/112,793 2015-02-06
PCT/US2016/016708 WO2016127024A1 (en) 2015-02-06 2016-02-05 Pyridazinone macrocycles as irak inhibitors and uses thereof

Publications (3)

Publication Number Publication Date
RU2017130761A RU2017130761A (ru) 2019-03-06
RU2017130761A3 RU2017130761A3 (OSRAM) 2019-07-17
RU2708066C2 true RU2708066C2 (ru) 2019-12-04

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RU2017130761A RU2708066C2 (ru) 2015-02-06 2016-02-05 Макроциклы пиридазинона в качестве ингибиторов irak-киназы и их применения

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US (2) US9624246B2 (OSRAM)
EP (1) EP3253763B1 (OSRAM)
JP (1) JP6920202B2 (OSRAM)
KR (1) KR102551597B1 (OSRAM)
CN (1) CN107428765B (OSRAM)
AU (1) AU2016215184B2 (OSRAM)
BR (1) BR112017014970B1 (OSRAM)
CA (1) CA2970550C (OSRAM)
ES (1) ES2841452T3 (OSRAM)
IL (1) IL253519B (OSRAM)
MX (1) MX380929B (OSRAM)
RU (1) RU2708066C2 (OSRAM)
SG (1) SG11201704651UA (OSRAM)
WO (1) WO2016127024A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2818822C1 (ru) * 2020-09-30 2024-05-06 Асахи Касеи Фарма Корпорейшн Макроциклическое соединение
US12577258B2 (en) 2020-09-30 2026-03-17 Vernalis (R&D) Limited Macrocyclic compound

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
ES2841452T3 (es) * 2015-02-06 2021-07-08 Merck Patent Gmbh Macrociclos de piridazinona como inhibidores de IRAK y sus usos
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI733982B (zh) 2017-02-16 2021-07-21 美商基利科學股份有限公司 吡咯并[1,2-b]嗒衍生物
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
WO2019120267A1 (zh) * 2017-12-22 2019-06-27 成都先导药物开发股份有限公司 一种咪唑并[1,2-b]哒嗪大环类激酶抑制剂
MX2020009234A (es) * 2018-04-05 2020-10-12 Merck Patent Gmbh Compuestos de heteroarilo como inhibidores de cinasas asociadas con receptores de interleucina-1 (irak) tipo ii y usos de los mismos.
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
JP7164705B2 (ja) 2018-08-13 2022-11-01 ギリアード サイエンシーズ, インコーポレイテッド IRAK4阻害剤としてのピロロ[1,2-b]ピリダジン誘導体
US11572362B2 (en) 2018-08-13 2023-02-07 Gilead Sciences, Inc. Pyrrolo[1,2-b]pyridazine derivatives
TWI727392B (zh) 2018-08-13 2021-05-11 美商基利科學股份有限公司 噻二唑irak4抑制劑
US11998534B2 (en) * 2020-02-12 2024-06-04 Eubulus Biotherapeutics Inc. GPX4 inhibitor in combination with anticancer agent for treating proliferative disease
CN111603471B (zh) * 2020-06-24 2021-07-09 山东省科学院生物研究所 一种邻二氮杂环化合物在制备抑制tlr4受体的药物中的用途

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RU2232755C2 (ru) * 1999-02-26 2004-07-20 Кова Ко., Лтд. Производные пиридазин-3-она и содержащие их лекарственные средства
WO2014058691A1 (en) * 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2014121942A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Macrocyclic pyridazinone derivatives

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JP2010138073A (ja) * 2007-03-30 2010-06-24 Taisho Pharmaceutical Co Ltd ピコリン酸アミド化合物
US8703768B2 (en) * 2010-06-09 2014-04-22 Hoffmann-La Roche Inc. Nitrogen containing heteroaryl compounds
HUE032863T2 (en) * 2013-02-07 2017-11-28 Merck Patent Gmbh Piridazinonamid derivatives
ES2841452T3 (es) * 2015-02-06 2021-07-08 Merck Patent Gmbh Macrociclos de piridazinona como inhibidores de IRAK y sus usos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2232755C2 (ru) * 1999-02-26 2004-07-20 Кова Ко., Лтд. Производные пиридазин-3-она и содержащие их лекарственные средства
WO2014058691A1 (en) * 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2014121942A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Macrocyclic pyridazinone derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2818822C1 (ru) * 2020-09-30 2024-05-06 Асахи Касеи Фарма Корпорейшн Макроциклическое соединение
US12577258B2 (en) 2020-09-30 2026-03-17 Vernalis (R&D) Limited Macrocyclic compound

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JP6920202B2 (ja) 2021-08-18
BR112017014970A2 (pt) 2018-03-27
AU2016215184B2 (en) 2020-11-12
AU2016215184A1 (en) 2017-06-29
IL253519B (en) 2021-01-31
IL253519A0 (en) 2017-09-28
MX2017009624A (es) 2017-11-20
US20160229871A1 (en) 2016-08-11
KR102551597B1 (ko) 2023-07-05
NZ732527A (en) 2022-03-25
KR20170113551A (ko) 2017-10-12
RU2017130761A3 (OSRAM) 2019-07-17
RU2017130761A (ru) 2019-03-06
MX380929B (es) 2025-03-12
JP2018505166A (ja) 2018-02-22
CN107428765B (zh) 2020-12-29
WO2016127024A1 (en) 2016-08-11
BR112017014970B1 (pt) 2022-11-16
CA2970550C (en) 2023-09-19
US20170173019A1 (en) 2017-06-22
EP3253763A1 (en) 2017-12-13
US9624246B2 (en) 2017-04-18
HK1246287A1 (zh) 2018-09-07
CA2970550A1 (en) 2016-08-11
EP3253763B1 (en) 2020-09-30
SG11201704651UA (en) 2017-07-28
ES2841452T3 (es) 2021-07-08
CN107428765A (zh) 2017-12-01
US10517872B2 (en) 2019-12-31

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