ES2836208T3 - Ciclopirox, ciclopirox olamina o un profármaco de ciclopirox para usar en el tratamiento del cáncer de vejiga - Google Patents
Ciclopirox, ciclopirox olamina o un profármaco de ciclopirox para usar en el tratamiento del cáncer de vejiga Download PDFInfo
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- ES2836208T3 ES2836208T3 ES15859268T ES15859268T ES2836208T3 ES 2836208 T3 ES2836208 T3 ES 2836208T3 ES 15859268 T ES15859268 T ES 15859268T ES 15859268 T ES15859268 T ES 15859268T ES 2836208 T3 ES2836208 T3 ES 2836208T3
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- ciclopirox
- pom
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- bladder cancer
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
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- 239000011859 microparticle Substances 0.000 description 1
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- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
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- VVWRJUBEIPHGQF-MDZDMXLPSA-N propan-2-yl (ne)-n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)\N=N\C(=O)OC(C)C VVWRJUBEIPHGQF-MDZDMXLPSA-N 0.000 description 1
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
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- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
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- IWOLVLSIZCEOHM-UHFFFAOYSA-M silver;dibenzyl phosphate Chemical compound [Ag+].C=1C=CC=CC=1COP(=O)([O-])OCC1=CC=CC=C1 IWOLVLSIZCEOHM-UHFFFAOYSA-M 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462078069P | 2014-11-11 | 2014-11-11 | |
| US201562134747P | 2015-03-18 | 2015-03-18 | |
| PCT/US2015/059955 WO2016077346A1 (en) | 2014-11-11 | 2015-11-10 | Methods of bladder cancer treatment with ciclopirox, ciclopirox olamine, or a ciclopirox prodrug |
Publications (1)
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|---|---|
| ES2836208T3 true ES2836208T3 (es) | 2021-06-24 |
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|---|---|---|---|
| ES15859268T Active ES2836208T3 (es) | 2014-11-11 | 2015-11-10 | Ciclopirox, ciclopirox olamina o un profármaco de ciclopirox para usar en el tratamiento del cáncer de vejiga |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20170304329A1 (https=) |
| EP (1) | EP3217980B1 (https=) |
| JP (1) | JP2017533952A (https=) |
| CN (2) | CN116687941A (https=) |
| DK (1) | DK3217980T3 (https=) |
| ES (1) | ES2836208T3 (https=) |
| HR (1) | HRP20201893T1 (https=) |
| HU (1) | HUE052670T2 (https=) |
| PT (1) | PT3217980T (https=) |
| RS (1) | RS61222B1 (https=) |
| WO (1) | WO2016077346A1 (https=) |
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|---|---|---|---|---|
| CN112351970A (zh) * | 2018-05-30 | 2021-02-09 | 科莱恩国际有限公司 | 2-羟基吡啶-1-氧化物或其衍生物的形成方法 |
| CN113194945B (zh) * | 2018-08-23 | 2024-07-23 | 佩勒梅德有限公司 | 环吡酮的抑制hbv核心组装的用途 |
| WO2021078937A1 (en) * | 2019-10-25 | 2021-04-29 | Deutsches Krebsforschungszentrum | Treatment of stat3 related diseases by iron chelators |
| EP4193989A1 (en) | 2021-12-09 | 2023-06-14 | Atlas Molecular Pharma, S.L. | A formulation for an effective oral administration of ciclopirox with no adversal gasterointestinal toxicity |
Family Cites Families (5)
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|---|---|---|---|---|
| AU754965B2 (en) | 1997-12-31 | 2002-11-28 | University Of Kansas, The | Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof |
| AU2003251875A1 (en) * | 2002-07-15 | 2004-02-02 | Combinatorx, Incorporated | Combination therapy for the treatment of neoplasms |
| US20110212176A1 (en) | 2008-10-31 | 2011-09-01 | University Health Network | Ciclopirox and cytarabine for the treatment of leukemic disorders |
| EP2576513A1 (en) * | 2010-06-01 | 2013-04-10 | Biotheryx Inc. | Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases |
| JP5853028B2 (ja) * | 2010-12-02 | 2016-02-09 | カンザス大学 | ６−シクロヘキシル−１−ヒドロキシ−４−メチルピリジン−２（１ｈ）−オンのプロドラッグおよびその誘導体 |
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2015
- 2015-11-10 CN CN202310102470.8A patent/CN116687941A/zh active Pending
- 2015-11-10 HU HUE15859268A patent/HUE052670T2/hu unknown
- 2015-11-10 RS RS20201438A patent/RS61222B1/sr unknown
- 2015-11-10 JP JP2017526594A patent/JP2017533952A/ja active Pending
- 2015-11-10 DK DK15859268.3T patent/DK3217980T3/da active
- 2015-11-10 ES ES15859268T patent/ES2836208T3/es active Active
- 2015-11-10 HR HRP20201893TT patent/HRP20201893T1/hr unknown
- 2015-11-10 PT PT158592683T patent/PT3217980T/pt unknown
- 2015-11-10 CN CN201580061284.8A patent/CN107206012A/zh active Pending
- 2015-11-10 US US15/526,164 patent/US20170304329A1/en not_active Abandoned
- 2015-11-10 WO PCT/US2015/059955 patent/WO2016077346A1/en not_active Ceased
- 2015-11-10 EP EP15859268.3A patent/EP3217980B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016077346A1 (en) | 2016-05-19 |
| HUE052670T2 (hu) | 2021-05-28 |
| EP3217980A4 (en) | 2018-05-02 |
| CN107206012A (zh) | 2017-09-26 |
| US20170304329A1 (en) | 2017-10-26 |
| PT3217980T (pt) | 2020-12-11 |
| CN116687941A (zh) | 2023-09-05 |
| RS61222B1 (sr) | 2021-01-29 |
| JP2017533952A (ja) | 2017-11-16 |
| DK3217980T3 (da) | 2020-12-07 |
| EP3217980B1 (en) | 2020-10-14 |
| HRP20201893T1 (hr) | 2021-02-05 |
| EP3217980A1 (en) | 2017-09-20 |
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