JP2017533952A - シクロピロクス、シクロピロクスオラミン又はシクロピロクスプロドラッグを用いる、膀胱癌の処置方法 - Google Patents

シクロピロクス、シクロピロクスオラミン又はシクロピロクスプロドラッグを用いる、膀胱癌の処置方法 Download PDF

Info

Publication number
JP2017533952A
JP2017533952A JP2017526594A JP2017526594A JP2017533952A JP 2017533952 A JP2017533952 A JP 2017533952A JP 2017526594 A JP2017526594 A JP 2017526594A JP 2017526594 A JP2017526594 A JP 2017526594A JP 2017533952 A JP2017533952 A JP 2017533952A
Authority
JP
Japan
Prior art keywords
ciclopirox
cpx
aliphatic
bladder cancer
pom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017526594A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017533952A5 (https=
Inventor
ジェイ．ウィアー スコット
ジェイ．ウィアー スコット
アナント シュリカント
アナント シュリカント
Original Assignee
ザ ユニバーシティ オブ カンザス
ザ ユニバーシティ オブ カンザス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ ユニバーシティ オブ カンザス, ザ ユニバーシティ オブ カンザス filed Critical ザ ユニバーシティ オブ カンザス
Publication of JP2017533952A publication Critical patent/JP2017533952A/ja
Publication of JP2017533952A5 publication Critical patent/JP2017533952A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017526594A 2014-11-11 2015-11-10 シクロピロクス、シクロピロクスオラミン又はシクロピロクスプロドラッグを用いる、膀胱癌の処置方法 Pending JP2017533952A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462078069P 2014-11-11 2014-11-11
US62/078,069 2014-11-11
US201562134747P 2015-03-18 2015-03-18
US62/134,747 2015-03-18
PCT/US2015/059955 WO2016077346A1 (en) 2014-11-11 2015-11-10 Methods of bladder cancer treatment with ciclopirox, ciclopirox olamine, or a ciclopirox prodrug

Publications (2)

Publication Number Publication Date
JP2017533952A true JP2017533952A (ja) 2017-11-16
JP2017533952A5 JP2017533952A5 (https=) 2018-12-20

Family

ID=55954945

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017526594A Pending JP2017533952A (ja) 2014-11-11 2015-11-10 シクロピロクス、シクロピロクスオラミン又はシクロピロクスプロドラッグを用いる、膀胱癌の処置方法

Country Status (11)

Country Link
US (1) US20170304329A1 (https=)
EP (1) EP3217980B1 (https=)
JP (1) JP2017533952A (https=)
CN (2) CN116687941A (https=)
DK (1) DK3217980T3 (https=)
ES (1) ES2836208T3 (https=)
HR (1) HRP20201893T1 (https=)
HU (1) HUE052670T2 (https=)
PT (1) PT3217980T (https=)
RS (1) RS61222B1 (https=)
WO (1) WO2016077346A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112351970A (zh) * 2018-05-30 2021-02-09 科莱恩国际有限公司 2-羟基吡啶-1-氧化物或其衍生物的形成方法
CN113194945B (zh) * 2018-08-23 2024-07-23 佩勒梅德有限公司 环吡酮的抑制hbv核心组装的用途
WO2021078937A1 (en) * 2019-10-25 2021-04-29 Deutsches Krebsforschungszentrum Treatment of stat3 related diseases by iron chelators
EP4193989A1 (en) 2021-12-09 2023-06-14 Atlas Molecular Pharma, S.L. A formulation for an effective oral administration of ciclopirox with no adversal gasterointestinal toxicity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004007676A2 (en) * 2002-07-15 2004-01-22 Combinatorx, Incorporated Combination therapy for the treatment of neoplasms
JP2013528619A (ja) * 2010-06-01 2013-07-11 ビオトヘルイク， インコーポレイテッド ヒドロキシピリドン誘導体、その医薬組成物、及び増殖性疾患治療のためのその治療的使用
JP2013544289A (ja) * 2010-12-02 2013-12-12 カンザス大学 ６−シクロヘキシル−１−ヒドロキシ−４−メチルピリジン−２（１ｈ）−オンのプロドラッグおよびその誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU754965B2 (en) 1997-12-31 2002-11-28 University Of Kansas, The Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
US20110212176A1 (en) 2008-10-31 2011-09-01 University Health Network Ciclopirox and cytarabine for the treatment of leukemic disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004007676A2 (en) * 2002-07-15 2004-01-22 Combinatorx, Incorporated Combination therapy for the treatment of neoplasms
JP2013528619A (ja) * 2010-06-01 2013-07-11 ビオトヘルイク， インコーポレイテッド ヒドロキシピリドン誘導体、その医薬組成物、及び増殖性疾患治療のためのその治療的使用
JP2013544289A (ja) * 2010-12-02 2013-12-12 カンザス大学 ６−シクロヘキシル−１−ヒドロキシ−４−メチルピリジン−２（１ｈ）−オンのプロドラッグおよびその誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
INT J CANCER, 2010, VOL.127(10), P.2467-2477, JPN6019040581, ISSN: 0004137882 *

Also Published As

Publication number Publication date
WO2016077346A1 (en) 2016-05-19
HUE052670T2 (hu) 2021-05-28
EP3217980A4 (en) 2018-05-02
CN107206012A (zh) 2017-09-26
US20170304329A1 (en) 2017-10-26
PT3217980T (pt) 2020-12-11
CN116687941A (zh) 2023-09-05
RS61222B1 (sr) 2021-01-29
ES2836208T3 (es) 2021-06-24
DK3217980T3 (da) 2020-12-07
EP3217980B1 (en) 2020-10-14
HRP20201893T1 (hr) 2021-02-05
EP3217980A1 (en) 2017-09-20

Similar Documents

Publication Publication Date Title
US11485726B2 (en) Compound for inhibiting and degrading tyrosine protein kinase ALK
JP6193268B2 (ja) Ｃｄｋ８／ｃｄｋ１９選択的阻害剤、ならびに癌のための抗転移および化学防御の方法におけるそれらの使用
US9545413B2 (en) Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug
US10450305B2 (en) LKB1-AMPK activators for therapeutic use in polycystic kidney disease
CN113573734A (zh) 治疗癌症的方法
EA023804B1 (ru) Оксабициклогептаны, их получение и применение
CN113143965B (zh) 一种抑制肿瘤增殖的氨基富勒烯材料
CN101528754A (zh) 使用结合wrn的分子的治疗方法
US20200123165A1 (en) Kinase inhibitors
US20200102264A1 (en) Marmelin analogs and methods of use in cancer treatment
JP2017533952A (ja) シクロピロクス、シクロピロクスオラミン又はシクロピロクスプロドラッグを用いる、膀胱癌の処置方法
CN106995368B (zh) 一种非atp竞争性fgfr1抑制剂及其应用
US12435091B2 (en) RNA-binding protein multimerization inhibitors and methods of use thereof
CN102532192B (zh) 一种对乙酰氨基酚—磷酰氮芥抗肿瘤药物及其制备方法
CN118043053A (zh) 治疗癌症的方法
WO2022118966A1 (ja) 細胞内への核酸分子取り込み促進剤、医薬組成物、及び新規化合物
US20250228950A1 (en) Prodrugs Activated by Reduction in the Cytosol
US20250162994A1 (en) Dual lsd1/hdac inhibitors
WO2025194120A1 (en) Zwitterionic polymer functionalized lipid nanoparticles for delivery of nucleic acids

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181109

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181109

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191029

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200128

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200623