ES2826386T3 - Antagonistas del receptor 5HT6 para uso en el tratamiento de la enfermedad de Alzheimer con apatía como comorbilidad - Google Patents
Antagonistas del receptor 5HT6 para uso en el tratamiento de la enfermedad de Alzheimer con apatía como comorbilidad Download PDFInfo
- Publication number
- ES2826386T3 ES2826386T3 ES17723326T ES17723326T ES2826386T3 ES 2826386 T3 ES2826386 T3 ES 2826386T3 ES 17723326 T ES17723326 T ES 17723326T ES 17723326 T ES17723326 T ES 17723326T ES 2826386 T3 ES2826386 T3 ES 2826386T3
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- receptor antagonist
- pharmaceutically acceptable
- apathy
- disease
- alzheimer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201600286 | 2016-05-11 | ||
| PCT/EP2017/060979 WO2017194496A1 (en) | 2016-05-11 | 2017-05-09 | 5ht6 receptor antagonists for use in the treatment of alzheimer's disease with apathy as comorbidity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2826386T3 true ES2826386T3 (es) | 2021-05-18 |
Family
ID=58707519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17723326T Active ES2826386T3 (es) | 2016-05-11 | 2017-05-09 | Antagonistas del receptor 5HT6 para uso en el tratamiento de la enfermedad de Alzheimer con apatía como comorbilidad |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10864191B2 (OSRAM) |
| EP (1) | EP3454848B1 (OSRAM) |
| JP (2) | JP6961622B2 (OSRAM) |
| CN (1) | CN109069466B (OSRAM) |
| BR (1) | BR112018000568A2 (OSRAM) |
| ES (1) | ES2826386T3 (OSRAM) |
| WO (1) | WO2017194496A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US10864191B2 (en) * | 2016-05-11 | 2020-12-15 | H. Lundbeck A/S | 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity |
| SMT202100240T1 (it) | 2017-05-24 | 2021-05-07 | H Lundbeck As | Combinazione di un antagonista del recettore di 5-ht6 e un inibitore della acetilcolinesterasi per l'uso nel trattamento della malattia di alzheimer in una sottopopolazione di pazienti portatori di alleli apoe4 |
| KR20250069704A (ko) * | 2017-06-30 | 2025-05-19 | 체이스 테라퓨틱스 코포레이션 | 우울증을 치료하기 위한 nk-1 길항제 조성물 및 우울증 치료에 사용하는 방법 |
| MX2022006537A (es) | 2019-12-02 | 2022-12-13 | Suven Life Sciences Ltd | Métodos para tratar síntomas de comportamiento y psicológicos en pacientes con demencia. |
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| US2006641A (en) * | 1932-09-26 | 1935-07-02 | Charles E Johnson | Hydraulic tappet |
| KR100894189B1 (ko) | 2001-03-29 | 2009-04-22 | 일라이 릴리 앤드 캄파니 | 5-ｈｔ6 수용체의 길항제로서의 ｎ-(2-아릴에틸)벤질아민 |
| PE20071143A1 (es) * | 2006-01-13 | 2008-01-20 | Wyeth Corp | Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 |
| AR061637A1 (es) * | 2006-06-26 | 2008-09-10 | Epix Delaware Inc | Composiciones y metodos de tratamiento de trastornos del snc |
| WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| EA017805B1 (ru) | 2008-01-24 | 2013-03-29 | Андрей Александрович ИВАЩЕНКО | 2-АЛКИЛАМИНО-3-АРИЛСУЛЬФОНИЛЦИКЛОАЛКАНО[e ИЛИ d]ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| RU2369600C1 (ru) | 2008-01-24 | 2009-10-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| WO2009093210A2 (ru) | 2008-01-24 | 2009-07-30 | Alla Chem, Llc | ЗАМЕЩЕННЫЕ ЦИKЛOAЛKAHO[e ИЛИ d]ПИPAЗOЛO[l,5-a]ПИPИMИДИHЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| EA017968B1 (ru) | 2008-01-24 | 2013-04-30 | Андрей Александрович ИВАЩЕНКО | ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| JO3459B1 (ar) * | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| US10864191B2 (en) * | 2016-05-11 | 2020-12-15 | H. Lundbeck A/S | 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity |
-
2017
- 2017-05-05 US US15/587,935 patent/US10864191B2/en active Active
- 2017-05-09 JP JP2018559275A patent/JP6961622B2/ja active Active
- 2017-05-09 WO PCT/EP2017/060979 patent/WO2017194496A1/en not_active Ceased
- 2017-05-09 ES ES17723326T patent/ES2826386T3/es active Active
- 2017-05-09 BR BR112018000568A patent/BR112018000568A2/pt not_active Application Discontinuation
- 2017-05-09 CN CN201780028711.1A patent/CN109069466B/zh active Active
- 2017-05-09 EP EP17723326.9A patent/EP3454848B1/en active Active
-
2021
- 2021-10-13 JP JP2021168436A patent/JP7217789B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3454848B1 (en) | 2020-09-09 |
| JP6961622B2 (ja) | 2021-11-05 |
| BR112018000568A2 (pt) | 2018-09-11 |
| CN109069466B (zh) | 2021-06-15 |
| JP2022009121A (ja) | 2022-01-14 |
| EP3454848A1 (en) | 2019-03-20 |
| US10864191B2 (en) | 2020-12-15 |
| US20170326107A1 (en) | 2017-11-16 |
| JP7217789B2 (ja) | 2023-02-03 |
| CN109069466A (zh) | 2018-12-21 |
| WO2017194496A1 (en) | 2017-11-16 |
| JP2019518736A (ja) | 2019-07-04 |
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