ES2817802T3 - Métodos para purificar una proteína objetivo de una o más impurezas en una muestra - Google Patents
Métodos para purificar una proteína objetivo de una o más impurezas en una muestra Download PDFInfo
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- ES2817802T3 ES2817802T3 ES10807153T ES10807153T ES2817802T3 ES 2817802 T3 ES2817802 T3 ES 2817802T3 ES 10807153 T ES10807153 T ES 10807153T ES 10807153 T ES10807153 T ES 10807153T ES 2817802 T3 ES2817802 T3 ES 2817802T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
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| US27370909P | 2009-08-07 | 2009-08-07 | |
| PCT/US2010/044539 WO2011017514A1 (en) | 2009-08-07 | 2010-08-05 | Methods for purifying a target protein from one or more impurities in a sample |
Publications (1)
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| ES2817802T3 true ES2817802T3 (es) | 2021-04-08 |
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| ES10807153T Active ES2817802T3 (es) | 2009-08-07 | 2010-08-05 | Métodos para purificar una proteína objetivo de una o más impurezas en una muestra |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8536316B2 (en, 2012) |
| EP (1) | EP2462157B1 (en, 2012) |
| JP (2) | JP5791602B2 (en, 2012) |
| KR (1) | KR101415660B1 (en, 2012) |
| CN (2) | CN102574911B (en, 2012) |
| ES (1) | ES2817802T3 (en, 2012) |
| IN (1) | IN2012DN00338A (en, 2012) |
| SG (1) | SG177577A1 (en, 2012) |
| WO (1) | WO2011017514A1 (en, 2012) |
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| JP3237179B2 (ja) | 1992-03-18 | 2001-12-10 | 栗田工業株式会社 | 排超純水中の過酸化水素の除去方法 |
| EP2695889A1 (en) * | 2009-12-29 | 2014-02-12 | Dr. Reddy's Laboratories Limited | Protein purification by ion exchange |
| ES2991883T3 (es) | 2010-05-25 | 2024-12-05 | Hoffmann La Roche | Procedimientos de purificación de polipéptidos |
| EP2598223B1 (en) | 2010-07-30 | 2022-04-06 | EMD Millipore Corporation | Chromatography media and method |
| MX339533B (es) | 2011-05-27 | 2016-05-30 | Abbvie Biotechnology Ltd | Composiciones y metodos de daclizumab (dac) del proceso de alto rendimiento (hyp). |
| AU2012269240B2 (en) | 2011-06-16 | 2016-01-21 | Dpx Holdings B.V. | Single unit chromatography antibody purification |
| US9556258B2 (en) | 2011-07-08 | 2017-01-31 | Merck Sharp & Dohme Corp. | Purification of fusion proteins |
| CA2842559A1 (en) * | 2011-07-20 | 2013-01-24 | Zepteon, Incorporated | Polypeptide separation methods |
| BR112014002133A2 (pt) * | 2011-08-01 | 2017-02-21 | Avaxia Biologics Inc | anticorpo policlonal bovino específico para tnf humano |
| US9096648B2 (en) * | 2011-08-19 | 2015-08-04 | Emd Millipore Corporation | Methods of reducing level of one or more impurities in a sample during protein purification |
| US20140228548A1 (en) * | 2011-09-01 | 2014-08-14 | Human Genome Sciences | Viral clearance methods |
| EP2578286A1 (en) * | 2011-10-04 | 2013-04-10 | Merck Patent GmbH | Method and apparatus for chromatographic purification |
| EP3257564B2 (en) * | 2011-11-02 | 2024-05-29 | F. Hoffmann-La Roche AG | Overload and elute chromatography |
| WO2013075740A1 (en) | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
| CN102492040B (zh) * | 2011-12-29 | 2014-06-25 | 嘉和生物药业有限公司 | 一种抗her2或/和抗her3抗体蛋白的纯化方法 |
| SG10201701224UA (en) * | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| EP2889617B1 (en) * | 2012-08-27 | 2017-10-11 | Asahi Kasei Medical Co., Ltd. | Antibody purification method by means of temperature-responsive chromatography |
| HUE036524T2 (hu) * | 2012-09-11 | 2018-07-30 | Coherus Biosciences Inc | Nagy tisztaságú és kiváló kitermelésû helyesen hajtogatott etanercept |
| US11628381B2 (en) | 2012-09-17 | 2023-04-18 | W.R. Grace & Co. Conn. | Chromatography media and devices |
| WO2014099577A1 (en) * | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
| ES2684527T3 (es) | 2013-02-14 | 2018-10-03 | Nanopareil, Llc | Fieltro híbrido de nanofibras electrohiladas, método de preparación del mismo y método de purificación de biomoléculas |
| DK3301115T3 (da) * | 2013-05-06 | 2022-01-31 | Sanofi Sa | Kontinuerlig flertrinsfremgangsmåde til oprensning af antistoffer |
| RU2016112549A (ru) * | 2013-09-05 | 2017-10-10 | Дженентек, Инк. | Способ для повторного использования хроматографии |
| KR20160054597A (ko) * | 2013-09-17 | 2016-05-16 | 가부시키가이샤 가네카 | 신규 항체 정제 방법 및 그로부터 얻어지는 항체, 및 양이온 교환기를 사용한 신규 항체 정제법 및 그로부터 얻어지는 항체 |
| EP3079808B1 (en) | 2013-12-12 | 2020-05-27 | EMD Millipore Corporation | Method of separating monomeric protein from protein agregates with a porous membrane comprising a co-polymer of benzyl acrylamide and acrylamide |
| EP3105580B1 (en) | 2014-02-14 | 2023-10-04 | Cytiva Sweden AB | Automated multi-step purification system |
| PL3116891T3 (pl) | 2014-03-10 | 2020-07-27 | Richter Gedeon Nyrt. | Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania |
| CN104826617B (zh) * | 2014-03-25 | 2017-06-13 | 西北大学 | 一种用于蛋白质分离的wax/hic双功能混合模式色谱固定相及其制备方法 |
| CN107847907A (zh) | 2014-05-02 | 2018-03-27 | 格雷斯公司 | 官能化载体材料以及制备和使用官能化载体材料的方法 |
| WO2015198320A1 (en) * | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
| DE102014010353B4 (de) | 2014-07-10 | 2024-09-12 | Sartorius Stedim Biotech Gmbh | Vorrichtung, Verwendung dieser Vorrichtung und Verfahren für die Stofftrennung mit verbesserter Ausnutzung der Kapazität chromatographischer Medien |
| US20170298091A1 (en) | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
| WO2016196906A1 (en) | 2015-06-05 | 2016-12-08 | W. R. Grace & Co.-Conn. | Adsorbent bioprocessing clarification agents and methods of making and using the same |
| WO2017176735A1 (en) * | 2016-04-05 | 2017-10-12 | Haemonetics Corporation | Methods and devices for the enrichment of immunoglobulin from blood |
| CN107964044B (zh) * | 2016-10-19 | 2021-11-19 | 无锡科捷诺生物科技有限责任公司 | 从乳样中纯化抗cd20单克隆抗体的方法 |
| CN111902720B (zh) | 2018-03-21 | 2025-02-07 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| EP3546475A1 (en) | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| US20210380638A1 (en) * | 2018-12-21 | 2021-12-09 | WuXi Biologics Ireland Limited | A method for improving aggregate removal by Protein A chromatography |
| FR3099066B1 (fr) * | 2019-07-26 | 2021-08-13 | Novasep Process | Procédé de purification d’une substance cible avec inactivation virale |
| TW202128264A (zh) * | 2019-09-25 | 2021-08-01 | 瑞士商赫孚孟拉羅股份公司 | 使用經預測之溶離緩衝鹽濃度的陽離子層析法 |
| CN114555622A (zh) * | 2019-10-04 | 2022-05-27 | 默克专利股份有限公司 | 蛋白质的纯化和病毒灭活 |
| CN110724204B (zh) * | 2019-11-18 | 2021-10-22 | 广东菲鹏制药股份有限公司 | Fc融合蛋白的纯化方法 |
| CN113845562A (zh) * | 2020-06-28 | 2021-12-28 | 佛山汉腾生物科技有限公司 | 目的蛋白纯化方法 |
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| US4490937A (en) * | 1981-12-07 | 1985-01-01 | Amcor Ltd. | Insect electrocution device |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5256694A (en) * | 1984-09-22 | 1993-10-26 | Basf Aktiengesellschaft | Diarylacetylenes, their preparation and their use |
| US5091178A (en) * | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
| US6054051A (en) * | 1996-01-17 | 2000-04-25 | Genentech, Inc. | Tangential-flow filtration system |
| KR100788093B1 (ko) * | 2002-04-26 | 2007-12-21 | 제넨테크, 인크. | 단백질의 비친화성 정제 |
| AU2003262087B2 (en) * | 2002-09-11 | 2010-11-11 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
| GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| US20080312425A1 (en) * | 2004-08-30 | 2008-12-18 | Lonza Biologics Plc. | Ion Exchange Chromatography and Purification of Antibodies |
| JP2010510963A (ja) | 2006-06-14 | 2010-04-08 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | セラミックヒドロキシアパタイトを使用する抗体の精製方法 |
| ZA200900836B (en) * | 2006-08-28 | 2010-05-26 | Ares Trading Sa | Process for the purification of FC-fusion proteins |
| JP2010501623A (ja) | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Ｆｃ含有タンパク質の精製法 |
| CA2673771A1 (en) * | 2007-01-17 | 2008-07-24 | Merck Serono S.A. | Process for the purification of fc-containing proteins |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US20090149638A1 (en) * | 2007-10-03 | 2009-06-11 | Ley Arthur C | Systems and methods for purifying proteins |
| US20110105725A1 (en) * | 2008-05-15 | 2011-05-05 | Novo Nordisk A/S | Antibody purification process |
| SG195577A1 (en) * | 2008-10-20 | 2013-12-30 | Abbott Lab | Viral inactivation during purification of antibodies |
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| KR20120089432A (ko) | 2012-08-10 |
| CN107188960A (zh) | 2017-09-22 |
| JP2013501721A (ja) | 2013-01-17 |
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| JP6335838B2 (ja) | 2018-05-30 |
| US8536316B2 (en) | 2013-09-17 |
| JP2015157846A (ja) | 2015-09-03 |
| CN102574911B (zh) | 2017-06-06 |
| IN2012DN00338A (en, 2012) | 2015-05-22 |
| EP2462157A4 (en) | 2012-12-26 |
| JP5791602B2 (ja) | 2015-10-07 |
| EP2462157A1 (en) | 2012-06-13 |
| KR101415660B1 (ko) | 2014-07-16 |
| WO2011017514A1 (en) | 2011-02-10 |
| SG177577A1 (en) | 2012-03-29 |
| CN102574911A (zh) | 2012-07-11 |
| US20110065901A1 (en) | 2011-03-17 |
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