ES2809199T3 - Modulación de la expresión de UBE3A-ATS - Google Patents
Modulación de la expresión de UBE3A-ATS Download PDFInfo
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- ES2809199T3 ES2809199T3 ES18188705T ES18188705T ES2809199T3 ES 2809199 T3 ES2809199 T3 ES 2809199T3 ES 18188705 T ES18188705 T ES 18188705T ES 18188705 T ES18188705 T ES 18188705T ES 2809199 T3 ES2809199 T3 ES 2809199T3
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- ES
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- ube3a
- modified oligonucleotide
- modified
- antisense
- ats
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/341—Gapmers, i.e. of the type ===---===
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| US201261664083P | 2012-06-25 | 2012-06-25 | |
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| US201361750939P | 2013-01-10 | 2013-01-10 | |
| US201361755617P | 2013-01-23 | 2013-01-23 | |
| US201361772925P | 2013-03-05 | 2013-03-05 |
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| ES2809199T3 (es) | 2012-06-25 | 2021-03-03 | Ionis Pharmaceuticals Inc | Modulación de la expresión de UBE3A-ATS |
| WO2016086104A1 (en) * | 2014-11-25 | 2016-06-02 | Ionis Pharmaceuticals, Inc. | Modulation of ube3a-ats expression |
| HUE062186T2 (hu) | 2015-05-07 | 2023-09-28 | Univ South Florida | Módosított UBE3A gén az Angelman-szindróma génterápiás megközelítésére |
| HUE067905T2 (hu) | 2015-11-12 | 2024-11-28 | Hoffmann La Roche | Oligonukleotidok paternális UBE3A expresszió indukálására |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| PT3717646T (pt) | 2017-12-01 | 2025-07-28 | Texas A & M Univ Sys | Tratamento antisense da síndrome de angelman |
| CN111770758A (zh) * | 2018-02-27 | 2020-10-13 | 北卡罗来纳-查佩尔山大学 | 用于治疗Angelman综合征的方法和组合物 |
| MX2020013667A (es) | 2018-06-14 | 2021-03-02 | Ovid Therapeutics Inc | Uso de mir-92a o mir-145 en el tratamiento del sindrome de angelman. |
| CA3113648A1 (en) | 2018-09-21 | 2020-03-26 | University Of Connecticut | Compositions and methods to restore paternal ube3a gene expression in human angelman syndrome |
| JP7241185B2 (ja) * | 2019-01-17 | 2023-03-16 | エフ． ホフマン－ラ ロシュ アーゲー | Ｅ３ユビキチンリガーゼ（ｕｂｅ３ａ）のタンパク質標的 |
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| WO2020237130A1 (en) * | 2019-05-22 | 2020-11-26 | The University Of North Carolina At Chapel Hill | Ube3a genes and expression cassettes and their use |
| WO2021011802A1 (en) * | 2019-07-16 | 2021-01-21 | The University Of North Carolina At Chapel Hill | Methods and compositions for unsilencing imprinted genes |
| GB201912103D0 (en) * | 2019-08-22 | 2019-10-09 | Univ Oxford Innovation Ltd | Method of haplotyping |
| EP4076471A4 (en) | 2019-12-18 | 2023-12-27 | National University of Singapore | Method for treating angelman syndrome and related disorders |
| EP4142802A4 (en) * | 2020-04-28 | 2024-07-24 | The Trustees of The University of Pennsylvania | COMPOSITIONS AND USES THEREOF FOR THE TREATMENT OF ANGELMAN SYNDROME |
| US20240018522A1 (en) * | 2020-10-26 | 2024-01-18 | Remix Therapeutics Inc. | Oligonucleotides useful for modulation of splicing |
| US20240318198A1 (en) * | 2021-02-03 | 2024-09-26 | The Board Of Regents Of The University Of Texas System | Gene therapy for angelman syndrome |
| US20240240179A1 (en) * | 2021-05-05 | 2024-07-18 | The General Hospital Corporation | Therapy for treatment of prader-willi syndrome |
| WO2023168000A1 (en) * | 2022-03-03 | 2023-09-07 | The Regents Of The University Of California | Compositions and methods for treatment of angelman syndrome |
| EP4532081A4 (en) | 2022-05-27 | 2025-09-17 | Zero Carbon Systems Inc | HIGH FLOW MOVING PANEL DIRECT AIR CAPTURE SYSTEM |
| WO2025101533A1 (en) * | 2023-11-09 | 2025-05-15 | Encoded Therapeutics, Inc. | Methods and compositions for increasing expression of ube3a |
| WO2025101991A1 (en) * | 2023-11-09 | 2025-05-15 | Ionis Pharmaceuticals, Inc. | Methods for modulating ube3a-ats |
| WO2025213123A1 (en) * | 2024-04-05 | 2025-10-09 | Encoded Therapeutics, Inc. | Methods and compositions for increasing expression of ube3a |
| TW202548015A (zh) * | 2024-04-11 | 2025-12-16 | 美商奧崔基尼克斯製藥公司 | 天使症候群反義治療的給藥方案 |
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-
2013
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- 2013-06-25 ES ES20182895T patent/ES2987225T3/es active Active
- 2013-06-25 PL PL18188705T patent/PL3461895T3/pl unknown
- 2013-06-25 SI SI201331770T patent/SI3461895T1/sl unknown
- 2013-06-25 EP EP20182895.1A patent/EP3770258B1/en active Active
- 2013-06-25 JP JP2015520410A patent/JP6294876B2/ja active Active
- 2013-06-25 DK DK18188705.0T patent/DK3461895T3/da active
- 2013-06-25 DK DK13809694.6T patent/DK2864479T3/en active
- 2013-06-25 HU HUE18188705A patent/HUE051698T2/hu unknown
- 2013-06-25 WO PCT/US2013/047701 patent/WO2014004572A2/en not_active Ceased
- 2013-06-25 PT PT181887050T patent/PT3461895T/pt unknown
- 2013-06-25 AU AU2013280474A patent/AU2013280474B2/en active Active
- 2013-06-25 ES ES13809694.6T patent/ES2688831T3/es active Active
- 2013-06-25 EP EP24188665.4A patent/EP4458361A3/en active Pending
- 2013-06-25 EP EP13809694.6A patent/EP2864479B1/en not_active Revoked
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Also Published As
| Publication number | Publication date |
|---|---|
| PL3461895T3 (pl) | 2021-01-11 |
| EP2864479A4 (en) | 2016-06-08 |
| US20150191723A1 (en) | 2015-07-09 |
| AU2013280474A1 (en) | 2015-01-22 |
| HUE051698T2 (hu) | 2021-03-29 |
| WO2014004572A2 (en) | 2014-01-03 |
| ES2688831T3 (es) | 2018-11-07 |
| US9617539B2 (en) | 2017-04-11 |
| EP2864479B1 (en) | 2018-08-15 |
| EP3461895B1 (en) | 2020-07-01 |
| PT3461895T (pt) | 2020-09-08 |
| CA2877905A1 (en) | 2014-01-03 |
| EP4458361A2 (en) | 2024-11-06 |
| WO2014004572A3 (en) | 2014-05-01 |
| EP4458361A3 (en) | 2025-01-22 |
| DK2864479T3 (en) | 2018-10-22 |
| JP6294876B2 (ja) | 2018-03-14 |
| JP2015529635A (ja) | 2015-10-08 |
| EP3770258B1 (en) | 2024-07-17 |
| EP2864479A2 (en) | 2015-04-29 |
| DK3461895T3 (da) | 2020-07-20 |
| SI3461895T1 (sl) | 2020-10-30 |
| EP3770258A1 (en) | 2021-01-27 |
| LT3461895T (lt) | 2020-09-10 |
| AU2013280474B2 (en) | 2019-01-03 |
| ES2987225T3 (es) | 2024-11-14 |
| EP3461895A1 (en) | 2019-04-03 |
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