ES2796858T3 - Derivados de espiroquinazolinona y su uso como moduladores alostéricos positivos de mglur4 - Google Patents
Derivados de espiroquinazolinona y su uso como moduladores alostéricos positivos de mglur4 Download PDFInfo
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- ES2796858T3 ES2796858T3 ES14701145T ES14701145T ES2796858T3 ES 2796858 T3 ES2796858 T3 ES 2796858T3 ES 14701145 T ES14701145 T ES 14701145T ES 14701145 T ES14701145 T ES 14701145T ES 2796858 T3 ES2796858 T3 ES 2796858T3
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- alkyl
- compound
- phenyl
- heteroaryl
- heterocyclyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
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- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
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- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361760367P | 2013-02-04 | 2013-02-04 | |
| PCT/EP2014/000169 WO2014117920A1 (en) | 2013-02-04 | 2014-01-23 | Spiro-quinazolinone derivatives useful for the treatment of neurological diseases and conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2796858T3 true ES2796858T3 (es) | 2020-11-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14701145T Active ES2796858T3 (es) | 2013-02-04 | 2014-01-23 | Derivados de espiroquinazolinona y su uso como moduladores alostéricos positivos de mglur4 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9708321B2 (enExample) |
| EP (1) | EP2951179B1 (enExample) |
| JP (1) | JP6402115B2 (enExample) |
| CN (1) | CN104955826B (enExample) |
| AU (1) | AU2014211728B2 (enExample) |
| CA (1) | CA2899957A1 (enExample) |
| ES (1) | ES2796858T3 (enExample) |
| WO (1) | WO2014117920A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016078771A1 (en) * | 2014-11-21 | 2016-05-26 | Laboratorios Del Dr. Esteve, S.A. | 1,9-diazaspiro undecane compounds having multimodal activity against pain |
| KR20180019234A (ko) | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
| JP6787913B2 (ja) | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
| CN108699013B (zh) | 2016-09-08 | 2022-05-06 | 嘉泉大学校校产学协力团 | 螺醌衍生物、其制备方法及含有其作为活性成分的用于预防或治疗神经疾患的药物组合物 |
| CA3102326A1 (en) | 2018-07-26 | 2020-01-30 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| WO2020108619A1 (zh) * | 2018-11-30 | 2020-06-04 | 上海迪诺医药科技有限公司 | Mnk抑制剂 |
| BR112022012015A2 (pt) | 2019-12-17 | 2022-08-30 | Merck Sharp & Dohme Llc | Inibidores de prmt5 |
| CN116157404B (zh) | 2020-08-14 | 2025-10-14 | 诺华股份有限公司 | 杂芳基取代的螺哌啶基衍生物及其药物用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3714093A (en) * | 1970-05-19 | 1973-01-30 | American Home Prod | Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones |
| JPS4867287A (enExample) * | 1971-12-20 | 1973-09-13 | ||
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
| AU2003263323A1 (en) * | 2002-09-07 | 2004-03-29 | Celltech R And D Limited | Quinazolinone derivatives |
| US7452911B2 (en) | 2002-10-31 | 2008-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE10250708A1 (de) | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| JP4710606B2 (ja) | 2003-04-18 | 2011-06-29 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| JPWO2008102749A1 (ja) | 2007-02-20 | 2010-05-27 | 武田薬品工業株式会社 | 複素環化合物 |
| GB0713686D0 (en) | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
| US20100144756A1 (en) | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| EP2110377A1 (en) * | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
| EP2311840A1 (en) | 2009-10-13 | 2011-04-20 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
| WO2010008521A1 (en) | 2008-07-14 | 2010-01-21 | Cropsolution, Inc. | Modulators of acetyl-coenzyme a carboxylase and methods of use thereof |
| AU2009307825A1 (en) * | 2008-10-22 | 2010-04-29 | Rick FRIEDMAN | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| WO2010094120A1 (en) | 2009-02-17 | 2010-08-26 | Merck Frosst Canada Ltd. | Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2011047481A1 (en) | 2009-10-23 | 2011-04-28 | Merck Frosst Canada Ltd. | Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| MX2012009378A (es) | 2010-02-11 | 2012-09-12 | Univ Vanderbilt | Compuestos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno y pirazolotiazol como potenciadores alostericos mglur4, composiciones y metodos para tratar disfunciones neurologicas. |
| WO2011143444A2 (en) | 2010-05-14 | 2011-11-17 | President And Fellows Of Harvard College | Diphenylbutypiperidine autophagy inducers |
| ITMI20122221A1 (it) * | 2012-12-21 | 2014-06-22 | C4T S C A R L | Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende |
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2014
- 2014-01-23 CA CA2899957A patent/CA2899957A1/en not_active Abandoned
- 2014-01-23 AU AU2014211728A patent/AU2014211728B2/en not_active Ceased
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| AU2014211728B2 (en) | 2018-05-17 |
| CA2899957A1 (en) | 2014-08-07 |
| EP2951179A1 (en) | 2015-12-09 |
| JP6402115B2 (ja) | 2018-10-10 |
| US9708321B2 (en) | 2017-07-18 |
| CN104955826B (zh) | 2019-05-31 |
| CN104955826A (zh) | 2015-09-30 |
| JP2016506939A (ja) | 2016-03-07 |
| WO2014117920A1 (en) | 2014-08-07 |
| US20150361079A1 (en) | 2015-12-17 |
| EP2951179B1 (en) | 2020-03-11 |
| AU2014211728A1 (en) | 2015-09-17 |
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