ES2796858T3 - Derivados de espiroquinazolinona y su uso como moduladores alostéricos positivos de mglur4 - Google Patents
Derivados de espiroquinazolinona y su uso como moduladores alostéricos positivos de mglur4 Download PDFInfo
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- ES2796858T3 ES2796858T3 ES14701145T ES14701145T ES2796858T3 ES 2796858 T3 ES2796858 T3 ES 2796858T3 ES 14701145 T ES14701145 T ES 14701145T ES 14701145 T ES14701145 T ES 14701145T ES 2796858 T3 ES2796858 T3 ES 2796858T3
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- alkyl
- compound
- phenyl
- heteroaryl
- heterocyclyl
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Rheumatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361760367P | 2013-02-04 | 2013-02-04 | |
| PCT/EP2014/000169 WO2014117920A1 (en) | 2013-02-04 | 2014-01-23 | Spiro-quinazolinone derivatives useful for the treatment of neurological diseases and conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2796858T3 true ES2796858T3 (es) | 2020-11-30 |
Family
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Family Applications (1)
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| ES14701145T Active ES2796858T3 (es) | 2013-02-04 | 2014-01-23 | Derivados de espiroquinazolinona y su uso como moduladores alostéricos positivos de mglur4 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9708321B2 (enExample) |
| EP (1) | EP2951179B1 (enExample) |
| JP (1) | JP6402115B2 (enExample) |
| CN (1) | CN104955826B (enExample) |
| AU (1) | AU2014211728B2 (enExample) |
| CA (1) | CA2899957A1 (enExample) |
| ES (1) | ES2796858T3 (enExample) |
| WO (1) | WO2014117920A1 (enExample) |
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| US10022359B2 (en) | 2014-11-21 | 2018-07-17 | Esteve Pharmaceuticals, S.A. | 1,9-diazaspiro undecane compounds having multimodal activity against pain |
| EP3313836B1 (en) | 2015-06-26 | 2020-11-11 | Takeda Pharmaceutical Company Limited | 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor |
| JP6787913B2 (ja) | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3395804B1 (en) | 2016-09-08 | 2020-05-13 | Gachon University of Industry-Academic Cooperation Foundation | Novel spiroquinone derivative compound, production method thereof, and pharmaceutical composition for preventing or treating neurological disorders which contains same as active ingredient |
| CA3102326A1 (en) | 2018-07-26 | 2020-01-30 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| CN111253397B (zh) * | 2018-11-30 | 2023-11-14 | 上海迪诺医药科技有限公司 | Mnk抑制剂 |
| ES3022307T3 (en) * | 2019-12-17 | 2025-05-28 | Merck Sharp & Dohme Llc | Prmt5 inhibitors |
| UY39377A (es) | 2020-08-14 | 2022-03-31 | Novartis Ag | Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos |
Family Cites Families (20)
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| US3714093A (en) | 1970-05-19 | 1973-01-30 | American Home Prod | Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones |
| JPS4867287A (enExample) * | 1971-12-20 | 1973-09-13 | ||
| US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| WO2004022554A1 (en) * | 2002-09-07 | 2004-03-18 | Celltech R & D Limited | Quinazolinone derivatives |
| DE10250708A1 (de) | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US7452911B2 (en) | 2002-10-31 | 2008-11-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| EP1619193A4 (en) | 2003-04-18 | 2010-08-11 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
| EP2123652A1 (en) | 2007-02-20 | 2009-11-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US20100144756A1 (en) | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| GB0713686D0 (en) | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
| EP2311840A1 (en) | 2009-10-13 | 2011-04-20 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
| EP2110377A1 (en) | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
| EP2310015A4 (en) | 2008-07-14 | 2011-10-26 | Cropsolution Inc | ACETYL-COENZYME-CARBOXYLASE MODULATORS AND METHODS OF USE THEREOF |
| CA2751761A1 (en) * | 2008-10-22 | 2010-04-29 | House Ear Institute | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| WO2010094120A1 (en) | 2009-02-17 | 2010-08-26 | Merck Frosst Canada Ltd. | Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2011047481A1 (en) | 2009-10-23 | 2011-04-28 | Merck Frosst Canada Ltd. | Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2011100607A1 (en) * | 2010-02-11 | 2011-08-18 | Vanderbilt University | Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction |
| WO2011143444A2 (en) | 2010-05-14 | 2011-11-17 | President And Fellows Of Harvard College | Diphenylbutypiperidine autophagy inducers |
| ITMI20122221A1 (it) * | 2012-12-21 | 2014-06-22 | C4T S C A R L | Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende |
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2014
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Also Published As
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|---|---|
| JP2016506939A (ja) | 2016-03-07 |
| CN104955826B (zh) | 2019-05-31 |
| CN104955826A (zh) | 2015-09-30 |
| AU2014211728B2 (en) | 2018-05-17 |
| AU2014211728A1 (en) | 2015-09-17 |
| JP6402115B2 (ja) | 2018-10-10 |
| CA2899957A1 (en) | 2014-08-07 |
| US20150361079A1 (en) | 2015-12-17 |
| US9708321B2 (en) | 2017-07-18 |
| WO2014117920A1 (en) | 2014-08-07 |
| EP2951179A1 (en) | 2015-12-09 |
| EP2951179B1 (en) | 2020-03-11 |
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