ES278990A1 - Coating medicinal tablets - Google Patents

Coating medicinal tablets

Info

Publication number
ES278990A1
ES278990A1 ES0278990A ES278990A ES278990A1 ES 278990 A1 ES278990 A1 ES 278990A1 ES 0278990 A ES0278990 A ES 0278990A ES 278990 A ES278990 A ES 278990A ES 278990 A1 ES278990 A1 ES 278990A1
Authority
ES
Spain
Prior art keywords
coating
tablets
bed
film
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0278990A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES278990A1 publication Critical patent/ES278990A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Medicinal tablets are coated by tumbling a bed of the tablets and applying thereto a coating fluid comprising a low boiling (below 100 DEG C.) organic solvent system in which is dissolved at least one film-forming material which is composed of 80-100% of a non-toxic film-forming material soluble in water or in an aqueous medium of pH 1-7 and 20-0% of a non-toxic, film-forming, water-insoluble material and directing towards the bed of tablets, simultaneously with the application of the coating fluid, a gas stream having a velocity sufficient to exchange the gas present in the vicinity of the bed at least 20 times per minute. Specified soluble coating materials are hydroxypropylmethyl-cellulose, polyacrylic and polymethacrylic acids, polyvinylpyrrolidone and high molecular weight polymers of ethylene oxide. Specified insoluble polymers include shellac, cellulose esters, carboxylated vinyl acetate resins, carboxyl-containing styrene polymers, polymers of alkyl acrylates and methacrylates and copolymers thereof with methacrylic acid, fumaric acid rosin adducts and polyesters modified with rosin. The conventional "air suspension" coating technique is a suitable process for applying the coating, or alternatively, conventional pan-coating methods modified by directing a relatively high velocity gas stream towards the tumbling tablets may be used.ALSO:Medicinal tablets are coated by tumbling a bed of the tablets and applying thereto a coating fluid comprising a low boiling (below 100 DEG C) organic solvent system in which is dissolved at least one film-forming material which is composed of 80 to 100% of a non-toxic film-forming material soluble in water or in an aqueous medium of pH 1-7 and 20 to 0% of a non-toxic, film-forming, water-insoluble material and directing towards the bed of tablets, simultaneously with the application of the coating fluid, a gas stream having a velocity sufficient to exchange the gas present in the vicinity of the bed at least 20 times per minute. Specified soluble coating materials are hydroxypropylmethylcellulose, polyacrylic and polymethacrylic acids, polyvinylpyrolidene and high molecular weight polymers of ethylene oxide. Specified insoluble polymers include shellac, cellulose esters, carboxylated vinyl acetate resins, carboxyl-containing styrene polymers, polymers of alkyl acrylates and methacrylates and copolymers thereof with methacrylic acid, fumaric acid rosin adducts and polyesters modified with rosin. The conventional "air suspension" coating technique is a suitable process for applying the coating or, alternatively, conventional pan-coating methods modified by directing a relatively high velocity gas stream towards the tumbling tablets may be used.
ES0278990A 1961-07-10 1962-07-06 Coating medicinal tablets Expired ES278990A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12642561A 1961-07-10 1961-07-10

Publications (1)

Publication Number Publication Date
ES278990A1 true ES278990A1 (en) 1962-12-01

Family

ID=22424764

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0278990A Expired ES278990A1 (en) 1961-07-10 1962-07-06 Coating medicinal tablets

Country Status (4)

Country Link
BE (1) BE619823A (en)
BR (1) BR6240885D0 (en)
ES (1) ES278990A1 (en)
GB (1) GB1005424A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19630954A1 (en) * 1996-07-31 1998-02-05 Linde Ag Product coating

Also Published As

Publication number Publication date
GB1005424A (en) 1965-09-22
BR6240885D0 (en) 1973-06-14
BE619823A (en) 1963-01-07

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