ES2763432T3 - Composiciones y métodos para la administración de ácidos nucleicos a base de nanopolímeros - Google Patents

Composiciones y métodos para la administración de ácidos nucleicos a base de nanopolímeros Download PDF

Info

Publication number
ES2763432T3
ES2763432T3 ES11838933T ES11838933T ES2763432T3 ES 2763432 T3 ES2763432 T3 ES 2763432T3 ES 11838933 T ES11838933 T ES 11838933T ES 11838933 T ES11838933 T ES 11838933T ES 2763432 T3 ES2763432 T3 ES 2763432T3
Authority
ES
Spain
Prior art keywords
nucleic acid
poly
acetylglucosamine
nanoparticle composition
glcnac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11838933T
Other languages
English (en)
Spanish (es)
Inventor
John Vournakis
Marina Demcheva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marine Polymer Technologies Inc
Original Assignee
Marine Polymer Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marine Polymer Technologies Inc filed Critical Marine Polymer Technologies Inc
Application granted granted Critical
Publication of ES2763432T3 publication Critical patent/ES2763432T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
ES11838933T 2010-11-06 2011-11-07 Composiciones y métodos para la administración de ácidos nucleicos a base de nanopolímeros Active ES2763432T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41086310P 2010-11-06 2010-11-06
US41135810P 2010-11-08 2010-11-08
PCT/US2011/059558 WO2012061803A2 (en) 2010-11-06 2011-11-07 Compositions and methods for nanopolymer-based nucleic acid delivery

Publications (1)

Publication Number Publication Date
ES2763432T3 true ES2763432T3 (es) 2020-05-28

Family

ID=46025153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11838933T Active ES2763432T3 (es) 2010-11-06 2011-11-07 Composiciones y métodos para la administración de ácidos nucleicos a base de nanopolímeros

Country Status (10)

Country Link
US (3) US20130287853A1 (enExample)
EP (1) EP2635261B1 (enExample)
JP (2) JP6029591B2 (enExample)
CN (2) CN103282024A (enExample)
AU (3) AU2011323078B2 (enExample)
CA (1) CA2816999A1 (enExample)
ES (1) ES2763432T3 (enExample)
IL (1) IL226170B (enExample)
MX (1) MX358050B (enExample)
WO (1) WO2012061803A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871247B2 (en) 2007-02-19 2014-10-28 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
CA2796068C (en) 2010-04-15 2022-07-19 Marine Polymer Technologies, Inc. Anti-bacterial applications of poly-n-acetylglucosamine nanofibers
EP2635261B1 (en) * 2010-11-06 2019-10-23 Marine Polymer Technologies, Inc. Compositions and methods for nanopolymer-based nucleic acid delivery
MX356877B (es) 2011-04-15 2018-06-19 Marine Polymer Tech Inc Tratamiento de enfermedades con nanofibras de poli-n-acetil-glucosamina.
CA2968160C (en) * 2016-05-31 2024-01-02 Sachiko Sato Use of n-acetylglucosamine and derivatives thereof to treat muscle disorders
EP3693024A1 (en) * 2019-02-05 2020-08-12 Altona Diagnostics GmbH Control for nucleic acid preparation and/or detection methods
IT202200004574A1 (it) * 2022-03-10 2023-09-10 Sergio Ammendola Nanoparticelle di N-acetilglucosammina e loro applicazioni

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB0126923D0 (en) * 2001-11-09 2002-01-02 Procter & Gamble Chitosan compositions
US7780873B2 (en) * 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
JP2005281239A (ja) * 2004-03-30 2005-10-13 Nippon Zeon Co Ltd 鶏用dnaワクチン
CA2487564A1 (en) * 2004-11-12 2006-05-12 Valorisation Recherche Hscm Folic acid-chitosan-dna nanoparticles
EP2007765B1 (en) 2006-03-23 2012-06-27 Novartis AG Immunopotentiating compounds
CA2646539A1 (en) 2006-03-23 2007-09-27 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
EP2068917A2 (en) * 2006-09-22 2009-06-17 Government of the USA, as Represented by the Secretary, Department of Health and Human Services Compositions and methods for chitosan enhanced immune response
KR100882611B1 (ko) * 2006-11-14 2009-02-12 주식회사 키토라이프 표적 리간드로서 폴릭산이 도입된 유전자 전달체용저분자량 수용성 키토산 나노입자 및 이의 제조방법
KR20090108723A (ko) * 2007-01-31 2009-10-16 알러간, 인코포레이티드 안 약물 송달을 위한 신규한 생체적합물질 및 이의 제조방법 및 용도
US20100086613A1 (en) * 2008-10-03 2010-04-08 Chang-Jer Wu Chitosan vehicle and method for making same
US20100105139A1 (en) * 2008-10-27 2010-04-29 Remco Alexander Spanjaard Ligand Targeted Nanocapsules for the delivery of RNAi and other Agents
CA2833415A1 (en) * 2010-05-10 2011-11-17 Corporation De L'ecole Polytechnique De Montreal Gene therapy for diabetes with chitosan-delivered plasmid encoding glucagon-like peptide 1
EP2635261B1 (en) * 2010-11-06 2019-10-23 Marine Polymer Technologies, Inc. Compositions and methods for nanopolymer-based nucleic acid delivery

Also Published As

Publication number Publication date
AU2016201640A1 (en) 2016-04-07
AU2011323078B2 (en) 2016-04-14
CN108743562A (zh) 2018-11-06
AU2011323078A1 (en) 2013-05-02
WO2012061803A3 (en) 2012-08-16
EP2635261A2 (en) 2013-09-11
US20170128382A1 (en) 2017-05-11
US20130287853A1 (en) 2013-10-31
IL226170A0 (en) 2013-07-31
US20230157971A1 (en) 2023-05-25
CA2816999A1 (en) 2012-05-10
EP2635261A4 (en) 2014-09-17
MX358050B (es) 2018-08-03
JP2016164181A (ja) 2016-09-08
AU2013203247A1 (en) 2013-05-09
MX2013005016A (es) 2014-03-12
JP6029591B2 (ja) 2016-11-24
JP2014500250A (ja) 2014-01-09
CN103282024A (zh) 2013-09-04
EP2635261B1 (en) 2019-10-23
IL226170B (en) 2018-11-29
WO2012061803A2 (en) 2012-05-10

Similar Documents

Publication Publication Date Title
US20230157971A1 (en) Compositions and methods for nanopolymer-based nucleic acid delivery
US20230293608A1 (en) Oncolytic Vaccinia Virus
ES2467678T3 (es) Modificación del ARN, que produce unas estabilidad de transcripción y eficiencia de traducción aumentadas
ES2791152T3 (es) Moléculas de ácido nucleico artificiales para una expresión proteica mejorada
ES2826203T3 (es) Suministro pulmonar de ARN mensajero
ES2702466T3 (es) Procedimiento para aumentar la expresión de proteínas codificadas por ARN
ES2924739T3 (es) Moléculas de ácido nucleico artificiales
CN116685331A (zh) 用融合相关的小跨膜蛋白配制的蛋白脂质囊泡
Běláková et al. DNA vaccines: are they still just a powerful tool for the future?
CN102740894A (zh) 用于治疗缺血组织的sdf-1递送
Braun Muscular gene transfer using nonviral vectors
EP2022853A1 (en) Freeze-dried product for transferring nucleic acid, oligonucleic acid or derivative thereof
Firouzamandi et al. Preparation, characterization, and in ovo vaccination of dextran-spermine nanoparticle DNA vaccine coexpressing the fusion and hemagglutinin genes against Newcastle disease
Chen et al. Ultrasound‐and liposome microbubble‐mediated targeted gene transfer to cardiomyocytes in vivo accompanied by polyethylenimine
Shi et al. Improving DNA vaccination performance through a new microbubble design and an optimized sonoporation protocol
CN119866375A (zh) 非免疫原性环状非病毒dna载体
US20250195642A1 (en) Nucleic acid stabilizing solution for vaccines, therapy, diagnostics, storage, and transport
Doherty et al. An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression
RU2834627C1 (ru) ДНК-последовательности, предназначенные для вакцинации человека и животных от развития заболевания, вызванного штаммами Brucella
Eghbalsaeid et al. In ovo injection of antisense Cyp19a1 oligonucleotide for female-to-male sex reversal in chicken embryos
Brinkman Combining biomaterials and immunotherapeutic mRNA to combat cancer
WO2025193592A9 (en) Enhanced nuclear delivery of dna and compositions for use in practicing the same
You et al. Distribution and expression of recombinant plasmid encoding chicken interleukin-2
HK40019406B (en) Oncolytic vaccinia virus
Heuking et al. Pulmonary Delivery of Plasmid DNA for Disease Prevention and Therapy