ES2761697T3 - Proceso para preparar una emulsión de aceite en agua que contiene escualeno procedente de levaduras - Google Patents
Proceso para preparar una emulsión de aceite en agua que contiene escualeno procedente de levaduras Download PDFInfo
- Publication number
- ES2761697T3 ES2761697T3 ES11170769T ES11170769T ES2761697T3 ES 2761697 T3 ES2761697 T3 ES 2761697T3 ES 11170769 T ES11170769 T ES 11170769T ES 11170769 T ES11170769 T ES 11170769T ES 2761697 T3 ES2761697 T3 ES 2761697T3
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- squalene
- yeast
- oil
- water emulsion
- emulsion
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Classifications
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Virology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19048608P | 2008-08-28 | 2008-08-28 |
Publications (1)
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|---|---|
| ES2761697T3 true ES2761697T3 (es) | 2020-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES11170769T Active ES2761697T3 (es) | 2008-08-28 | 2009-08-28 | Proceso para preparar una emulsión de aceite en agua que contiene escualeno procedente de levaduras |
| ES09786243T Active ES2366941T3 (es) | 2008-08-28 | 2009-08-28 | Producción de escualeno a partir de levaduras hiperproductoras. |
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| ES09786243T Active ES2366941T3 (es) | 2008-08-28 | 2009-08-28 | Producción de escualeno a partir de levaduras hiperproductoras. |
Country Status (23)
| Country | Link |
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| US (2) | US11236366B2 (OSRAM) |
| EP (2) | EP2369003B1 (OSRAM) |
| JP (3) | JP4938911B2 (OSRAM) |
| KR (1) | KR101443064B1 (OSRAM) |
| CN (1) | CN102257149B (OSRAM) |
| AT (1) | ATE513920T1 (OSRAM) |
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| BR (1) | BRPI0917716A2 (OSRAM) |
| CA (1) | CA2735404C (OSRAM) |
| CY (1) | CY1114687T1 (OSRAM) |
| DK (1) | DK2268823T3 (OSRAM) |
| EA (1) | EA028898B1 (OSRAM) |
| ES (2) | ES2761697T3 (OSRAM) |
| HR (1) | HRP20110671T1 (OSRAM) |
| IL (1) | IL211435A (OSRAM) |
| MX (1) | MX2011002279A (OSRAM) |
| NZ (1) | NZ591876A (OSRAM) |
| PL (1) | PL2268823T3 (OSRAM) |
| PT (1) | PT2268823E (OSRAM) |
| RS (1) | RS51999B (OSRAM) |
| SI (1) | SI2268823T1 (OSRAM) |
| SM (1) | SMT201100058B (OSRAM) |
| WO (1) | WO2010023551A2 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EA201071338A1 (ru) | 2008-05-23 | 2012-01-30 | Сибас Ойлз, Ллс | Получение сквалена с применением дрожжей |
| EP2292741A1 (en) * | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
| HUE034245T2 (en) | 2009-11-23 | 2018-02-28 | Nucelis Llc | Methods and preparations for the preparation of squalene using yeast |
| MX352758B (es) | 2010-05-12 | 2017-12-07 | Novartis Ag Star | Metodos mejorados para preparar escualeno. |
| CN102100260B (zh) * | 2010-12-03 | 2013-07-31 | 滨州学院 | 酵母油脂及其制备方法和应用 |
| CN102787140A (zh) * | 2011-05-20 | 2012-11-21 | 罗盖特兄弟公司 | 从微藻制备与提取角鲨烯的工艺方法 |
| CN102787074B (zh) | 2011-05-20 | 2016-06-08 | 罗盖特兄弟公司 | 生产角鲨烯的微藻新菌株 |
| FR2975705B1 (fr) | 2011-05-27 | 2014-12-26 | Roquette Freres | Procede d'extraction du squalene a partir de microalgues |
| CN104159602B (zh) | 2012-03-08 | 2017-10-24 | 葛兰素史密丝克莱恩生物有限公司 | 加强疫苗的含佐剂制剂 |
| FR2989373B1 (fr) * | 2012-04-16 | 2016-05-06 | Roquette Freres | Procede de raffinage du squalene produit par microalgues |
| KR102192410B1 (ko) * | 2012-04-16 | 2020-12-17 | 로께뜨프레르 | 미세조류에 의해 생성된 스쿠알렌의 정련방법 |
| AU2013311702A1 (en) | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
| JP6440619B2 (ja) | 2012-10-12 | 2018-12-19 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 混合ワクチン用の架橋されていない無細胞百日咳抗原 |
| CA2894260A1 (en) | 2012-12-18 | 2014-06-26 | Glaxosmithkline Biologicals S.A. | Conjugates for protecting against diphtheria and/or tetanus |
| EP2971049B1 (en) | 2013-03-13 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Production of squalene and/or sterol from cell suspensions of fermented yeast |
| GB2518927A (en) * | 2013-05-21 | 2015-04-08 | Univ Swansea | The production of biomolecules using yeast |
| CN103849643A (zh) * | 2014-03-11 | 2014-06-11 | 北京理工大学 | 一种利用蛋白支架提高酿酒酵母中鲨烯的合成方法 |
| US10280406B2 (en) | 2014-04-09 | 2019-05-07 | Adeka Corporation | Mutant enzyme and production method for terpenoid using said mutant enzyme |
| EP3225691B1 (en) * | 2014-11-28 | 2020-10-28 | Ajinomoto Co., Inc. | Method for producing isoprenoid compound |
| ES2861806T3 (es) | 2014-12-02 | 2021-10-06 | Novartis Ag | Fabricación de composiciones que contienen tensioactivo |
| CN104560731B (zh) * | 2014-12-26 | 2018-10-09 | 中国科学院青岛生物能源与过程研究所 | 一种高产角鲨烯的类酵母菌及其应用 |
| CN110373338B (zh) * | 2019-08-15 | 2021-09-28 | 宜昌东阳光生化制药有限公司 | 酿酒酵母及其用途 |
| CN111893049A (zh) * | 2020-06-30 | 2020-11-06 | 厦门大学 | 一种过表达角鲨烯合成酶基因的裂殖壶菌基因工程菌株及其构建方法和应用 |
| WO2025053947A1 (en) * | 2023-09-07 | 2025-03-13 | Avantor Performance Materials, Llc | Synthetic triterpenes composition, method of production and applications thereof |
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| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| JP2785084B2 (ja) | 1991-11-18 | 1998-08-13 | 三菱石油株式会社 | スクアレンを生産する酵母の作製法及び作製された新規酵母 |
| JPH06116171A (ja) | 1992-10-06 | 1994-04-26 | Nippon Fine Chem Co Ltd | 天然スクワレンの精製方法 |
| DE4316620A1 (de) | 1993-05-18 | 1994-11-24 | Mueller Extract Co Gmbh | Verfahren und Vorrichtung zur Herstellung von Squalen aus Olivenölrückständen |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| JPH10120548A (ja) | 1996-10-23 | 1998-05-12 | Shiseido Co Ltd | 肌荒れ防止剤 |
| DE19744212B4 (de) * | 1997-09-30 | 2006-01-19 | Schering Ag | Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen |
| US20040235088A1 (en) | 1997-09-30 | 2004-11-25 | Schering Aktiengesellschaft | Process for the production of ergosterol and its intermediate products using recombinant yeasts |
| DE10012370A1 (de) * | 2000-03-14 | 2001-09-27 | Chiron Behring Gmbh & Co | Adjuvans für Vakzinen |
| US20020168389A1 (en) * | 2000-12-28 | 2002-11-14 | Prem Chandar | Stable skin conditioning compositions containing retinoid boosters |
| AU2005327457B2 (en) * | 2003-09-25 | 2012-08-23 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
| JP2007513613A (ja) * | 2003-12-12 | 2007-05-31 | サノフィ パストゥール リミテッド | ジフテリア毒素の産生 |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| US20060286046A1 (en) | 2005-01-05 | 2006-12-21 | Haber C Andrew | Skin care compositions |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| US7375188B2 (en) * | 2005-07-29 | 2008-05-20 | Mallinckrodt Baker, Inc. | Vegetarian protein a preparation and methods thereof |
| CA2617362A1 (en) | 2005-08-02 | 2007-02-08 | Novartis Vaccines And Diagnostics S.R.L. | Reducing interference between oil-containing adjuvants and surfactant-containing antigens |
| JP4210674B2 (ja) | 2005-08-31 | 2009-01-21 | 全国農業協同組合連合会 | マイコプラズマ・ガリセプティカム培養用培地 |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| JP5053557B2 (ja) * | 2006-03-24 | 2012-10-17 | 株式会社 資生堂 | 白濁状水中油型乳化化粧料の製造方法 |
| HUE036180T2 (hu) * | 2006-09-26 | 2018-06-28 | Infectious Disease Res Inst | Szintetikus adjuvánst tartalmazó vakcina készítmény |
| WO2008130372A2 (en) | 2006-09-28 | 2008-10-30 | Microbia, Inc. | Production of sterols in oleaginous yeast and fungi |
| CN101522218B (zh) | 2006-10-12 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 包含水包油乳液佐剂的疫苗 |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| US8092813B1 (en) * | 2007-12-28 | 2012-01-10 | Novartis Ag | Polychlorinated biphenyls and squalene-containing adjuvants |
| EA201071338A1 (ru) * | 2008-05-23 | 2012-01-30 | Сибас Ойлз, Ллс | Получение сквалена с применением дрожжей |
| EP2292741A1 (en) | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
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- 2009-08-28 US US13/061,505 patent/US11236366B2/en active Active
- 2009-08-28 EA EA201170381A patent/EA028898B1/ru not_active IP Right Cessation
- 2009-08-28 WO PCT/IB2009/006825 patent/WO2010023551A2/en not_active Ceased
- 2009-08-28 JP JP2011524473A patent/JP4938911B2/ja active Active
- 2009-08-28 EP EP09786243A patent/EP2268823B1/en active Active
- 2009-08-28 AT AT09786243T patent/ATE513920T1/de active
- 2009-08-28 ES ES09786243T patent/ES2366941T3/es active Active
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2011
- 2011-09-15 CY CY20111100893T patent/CY1114687T1/el unknown
- 2011-11-17 SM SM201100058T patent/SMT201100058B/it unknown
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2012
- 2012-02-23 JP JP2012036971A patent/JP5930766B2/ja not_active Expired - Fee Related
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2015
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2021
- 2021-12-20 US US17/555,867 patent/US20220177928A1/en not_active Abandoned
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