ES2743704T3 - Obtención de imágenes de IRM de la placa amiloide usando liposomas - Google Patents

Obtención de imágenes de IRM de la placa amiloide usando liposomas Download PDF

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Publication number
ES2743704T3
ES2743704T3 ES15849750T ES15849750T ES2743704T3 ES 2743704 T3 ES2743704 T3 ES 2743704T3 ES 15849750 T ES15849750 T ES 15849750T ES 15849750 T ES15849750 T ES 15849750T ES 2743704 T3 ES2743704 T3 ES 2743704T3
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Prior art keywords
phospholipid
liposomal composition
polymer
aromatic
substituted
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Application number
ES15849750T
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English (en)
Spanish (es)
Inventor
Ananth Annapragada
Eric A Tanifum
Mayank Srivastava
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Texas Childrens Hospital
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Texas Childrens Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1812Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • A61K49/0034Indocyanine green, i.e. ICG, cardiogreen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/12Macromolecular compounds
    • A61K49/126Linear polymers, e.g. dextran, inulin, PEG

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES15849750T 2014-10-08 2015-10-08 Obtención de imágenes de IRM de la placa amiloide usando liposomas Active ES2743704T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061514P 2014-10-08 2014-10-08
US201562111057P 2015-02-02 2015-02-02
PCT/US2015/054732 WO2016057812A1 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Publications (1)

Publication Number Publication Date
ES2743704T3 true ES2743704T3 (es) 2020-02-20

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
ES15849750T Active ES2743704T3 (es) 2014-10-08 2015-10-08 Obtención de imágenes de IRM de la placa amiloide usando liposomas
ES22152987T Active ES3032054T3 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES22152987T Active ES3032054T3 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Country Status (10)

Country Link
US (4) US9744251B2 (enExample)
EP (3) EP3204051B1 (enExample)
JP (1) JP6505235B2 (enExample)
KR (1) KR102409017B1 (enExample)
CN (1) CN107106708B (enExample)
AU (2) AU2015330824A1 (enExample)
CA (1) CA2963941C (enExample)
ES (2) ES2743704T3 (enExample)
MX (1) MX371295B (enExample)
WO (1) WO2016057812A1 (enExample)

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WO2018015546A1 (en) 2016-07-22 2018-01-25 Ac Immune S.A. Compounds for imaging tau protein aggregates
KR102472003B1 (ko) 2016-07-22 2022-11-29 에이씨 이뮨 에스에이 타우 단백질 응집체를 이미징하기 위한 화합물
EP3512570B1 (en) * 2016-09-16 2024-08-28 Texas Children's Hospital Liposomal gadolinium (gd) contrast agent for t1-mri
US11241510B2 (en) 2016-11-30 2022-02-08 Texas Children's Hospital Hydrophilic fluorinated molecules for liposomal 19F MRI probes with unique MR signatures
EP3743423A1 (en) 2018-01-24 2020-12-02 AC Immune SA Gamma-carboline compounds for the detection of tau aggregates
US20210041447A1 (en) 2018-01-24 2021-02-11 Ac Immune Sa Azacarboline compounds for the detection of tau aggregates
CN116173238A (zh) * 2018-03-29 2023-05-30 微脉管治疗有限公司 用于检测和治疗阿尔茨海默病的组合物及方法
WO2019234243A1 (en) 2018-06-08 2019-12-12 Ac Immune Sa Novel compounds for diagnosis
JP7545393B2 (ja) * 2019-01-24 2024-09-04 アルゼカ バイオサイエンシズ、エルエルシー 誤って折りたたまれたタンパク質を画像化するための機能化リポソーム
US20210128755A1 (en) * 2019-07-08 2021-05-06 Alzeca Biosciences, LLC Targeting ligands for tau pathology
US11614451B2 (en) 2019-07-08 2023-03-28 Alzeca Biosciences, LLC Targeting ligands for tau pathology
CN115916263B (zh) * 2020-01-29 2025-10-03 德克萨斯儿童医院 用于淀粉样蛋白沉积mri的靶向对比剂
US11779664B2 (en) 2020-02-12 2023-10-10 Texas Children's Hospital Targeted contrast agents for MRI of alpha-synuclein deposition
CN115279424A (zh) * 2020-02-12 2022-11-01 德克萨斯儿童医院 用于α-突触核蛋白沉积MRI的靶向对比剂
CN115970009A (zh) * 2023-02-08 2023-04-18 丽水市中心医院 Vhpk多肽修饰的荧光纳米脂质体给药系统、其制备方法及应用
CN116869938A (zh) * 2023-07-26 2023-10-13 安徽医科大学 一种1,2,4-噁二唑-吡啶脂质体及其制备方法和应用

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JP4829454B2 (ja) 1999-11-30 2011-12-07 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ 放射線感受性リポソーム
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Also Published As

Publication number Publication date
WO2016057812A1 (en) 2016-04-14
EP3204051A4 (en) 2018-06-27
US9744251B2 (en) 2017-08-29
MX371295B (es) 2020-01-24
AU2021203388A1 (en) 2021-06-24
US11141495B2 (en) 2021-10-12
US20160101197A1 (en) 2016-04-14
CN107106708A (zh) 2017-08-29
JP6505235B2 (ja) 2019-04-24
EP3204051B1 (en) 2019-05-29
US20170080111A1 (en) 2017-03-23
KR20170103748A (ko) 2017-09-13
HK1243335A1 (zh) 2018-07-13
ES3032054T3 (en) 2025-07-15
US20200179540A1 (en) 2020-06-11
EP4035688C0 (en) 2025-03-26
AU2015330824A1 (en) 2017-05-25
KR102409017B1 (ko) 2022-06-16
AU2021203388B2 (en) 2024-05-30
US20200069820A1 (en) 2020-03-05
EP4035688B1 (en) 2025-03-26
EP4035688A1 (en) 2022-08-03
JP2017532378A (ja) 2017-11-02
CN107106708B (zh) 2021-06-18
CA2963941C (en) 2023-08-01
BR112017007238A2 (pt) 2018-01-16
CA2963941A1 (en) 2016-04-14
US10537649B2 (en) 2020-01-21
EP3204051A1 (en) 2017-08-16
EP3542828A1 (en) 2019-09-25
MX2017004695A (es) 2018-01-24

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