ES2728119T3 - Identificación de estados celulares funcionales - Google Patents

Identificación de estados celulares funcionales Download PDF

Info

Publication number
ES2728119T3
ES2728119T3 ES15702063T ES15702063T ES2728119T3 ES 2728119 T3 ES2728119 T3 ES 2728119T3 ES 15702063 T ES15702063 T ES 15702063T ES 15702063 T ES15702063 T ES 15702063T ES 2728119 T3 ES2728119 T3 ES 2728119T3
Authority
ES
Spain
Prior art keywords
cells
cell
parameter
phenotypic
response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15702063T
Other languages
English (en)
Spanish (es)
Inventor
Bartlomiej Rajwa
T Vincent Shankey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ASEDASCIENCES AG
Original Assignee
ASEDASCIENCES AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ASEDASCIENCES AG filed Critical ASEDASCIENCES AG
Application granted granted Critical
Publication of ES2728119T3 publication Critical patent/ES2728119T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00Subject matter not provided for in other groups of this subclass
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30Prediction of properties of chemical compounds, compositions or mixtures
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/40Searching chemical structures or physicochemical data
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C99/00Subject matter not provided for in other groups of this subclass

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computing Systems (AREA)
  • Physiology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
ES15702063T 2014-01-14 2015-01-14 Identificación de estados celulares funcionales Active ES2728119T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461927247P 2014-01-14 2014-01-14
PCT/US2015/011441 WO2015109003A1 (en) 2014-01-14 2015-01-14 Identification of functional cell states

Publications (1)

Publication Number Publication Date
ES2728119T3 true ES2728119T3 (es) 2019-10-22

Family

ID=52440877

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15702063T Active ES2728119T3 (es) 2014-01-14 2015-01-14 Identificación de estados celulares funcionales

Country Status (11)

Country Link
US (3) US11137388B2 (enExample)
EP (1) EP3094974B1 (enExample)
JP (1) JP6606100B2 (enExample)
KR (1) KR102413041B1 (enExample)
AU (2) AU2015206520B2 (enExample)
CA (1) CA2972960C (enExample)
DK (1) DK3094974T3 (enExample)
ES (1) ES2728119T3 (enExample)
IL (1) IL246734B (enExample)
SG (1) SG11201705495XA (enExample)
WO (1) WO2015109003A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201705495XA (en) * 2014-01-14 2017-08-30 Asedasciences Ag Identification of functional cell states
EP4194801A1 (en) 2015-02-24 2023-06-14 The University of Tokyo Dynamic high-speed high-sensitivity imaging device and imaging method
CN108351289B (zh) * 2015-10-28 2021-11-26 国立大学法人东京大学 分析装置
US10824693B2 (en) * 2015-12-10 2020-11-03 Reservoir Labs, Inc. Systems and methods for selective expansive recursive tensor analysis
US11205103B2 (en) 2016-12-09 2021-12-21 The Research Foundation for the State University Semisupervised autoencoder for sentiment analysis
US12300357B2 (en) 2016-12-14 2025-05-13 FlowJo, LLC Applied computer technology for management, synthesis, visualization, and exploration of parameters in large multi-parameter data sets
EP3631417B1 (en) 2017-05-25 2024-02-14 Flowjo, LLC Visualization, comparative analysis, and automated difference detection for large multi-parameter data sets
JP7369385B2 (ja) 2018-06-13 2023-10-26 シンクサイト株式会社 サイトメトリーのための方法及びシステム
EP4641584A3 (en) 2019-05-14 2025-12-10 University of Pittsburgh - of the Commonwealth System of Higher Education System and method for characterizing cellular phenotypic diversity from multi-parameter cellular and sub-cellular imaging data
JP7556557B2 (ja) 2019-12-27 2024-09-26 シンクサイト株式会社 フローサイトメータ性能評価方法
EP4130714A4 (en) 2020-04-01 2024-04-17 ThinkCyte, Inc. FLOW CYTOMETER
JPWO2021200960A1 (enExample) 2020-04-01 2021-10-07
US12510479B2 (en) * 2020-07-30 2025-12-30 Allen Institute Systems, devices, and methods for compound screening using predictive tagging
WO2023009513A1 (en) 2021-07-26 2023-02-02 Asedasciences Ag Improved methods for identification of functional cell states
WO2023056481A1 (en) * 2021-10-01 2023-04-06 CAP Diagnostics, LLC, dba Pathnostics Automated methods and systems for rapid identification of target particles
US12105081B2 (en) * 2021-10-20 2024-10-01 Travera, Inc. Treatment response assessment using normalized single cell measurements
CN121359212A (zh) 2023-01-23 2026-01-16 阿斯达科学股份公司 增强人机交互系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5544650A (en) 1988-04-08 1996-08-13 Neuromedical Systems, Inc. Automated specimen classification system and method
WO1994016314A1 (en) 1993-01-08 1994-07-21 Coulter Corporation Method of using preserved control cells in the calibration of fluorescent and light scatter measurements
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US20050221280A1 (en) 1998-02-02 2005-10-06 Odyssey Thera, Inc. Protein-protein interactions for pharmacological profiling
US7166424B2 (en) 1998-02-02 2007-01-23 Odyssey Thera Inc. Fragments of fluorescent proteins for protein fragment complementation assays
US6801859B1 (en) 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6998249B1 (en) 1999-09-27 2006-02-14 Pharmacia & Upjohn Company Toxicity screening method
AU4007401A (en) 2000-03-06 2001-09-17 Bioseek Inc Function homology screening
US6834237B2 (en) 2000-06-02 2004-12-21 Medicometrics Aps Method and system for classifying a biological sample
US7146349B2 (en) * 2000-11-06 2006-12-05 International Business Machines Corporation Network for describing multimedia information
EP1620722A4 (en) 2003-04-23 2008-01-30 Bioseek Inc METHODS FOR CHARACTERIZING SIGNALING PATHWAYS AND COMPOUNDS INTERACTING THEREWITH
WO2004094992A2 (en) * 2003-04-23 2004-11-04 Bioseek, Inc. Methods for analysis of biological dataset profiles
WO2008134593A1 (en) 2007-04-25 2008-11-06 President And Fellows Of Harvard College Molecular circuits
US20130226469A1 (en) 2008-04-01 2013-08-29 Purdue Research Foundation Gate-free flow cytometry data analysis
WO2009146036A2 (en) * 2008-04-01 2009-12-03 Purdue Research Foundation Quantification of differences between measured values and statistical validation based on the differences
SG11201705495XA (en) * 2014-01-14 2017-08-30 Asedasciences Ag Identification of functional cell states

Also Published As

Publication number Publication date
JP2017505140A (ja) 2017-02-16
US11867690B2 (en) 2024-01-09
AU2021204419A1 (en) 2021-07-22
DK3094974T3 (da) 2019-05-27
EP3094974B1 (en) 2019-02-27
US20210364499A1 (en) 2021-11-25
US20160370350A1 (en) 2016-12-22
CA2972960C (en) 2022-01-11
KR20160110444A (ko) 2016-09-21
IL246734A0 (en) 2016-08-31
WO2015109003A1 (en) 2015-07-23
CA2972960A1 (en) 2015-07-23
SG11201705495XA (en) 2017-08-30
AU2015206520A1 (en) 2016-07-14
JP6606100B2 (ja) 2019-11-13
HK1231553A1 (en) 2017-12-22
KR102413041B1 (ko) 2022-06-23
IL246734B (en) 2019-06-30
EP3094974A1 (en) 2016-11-23
US11137388B2 (en) 2021-10-05
AU2015206520B2 (en) 2021-07-22
US20150198584A1 (en) 2015-07-16

Similar Documents

Publication Publication Date Title
US11867690B2 (en) Identification of functional cell states
Sirenko et al. Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity
US20240337647A1 (en) Improved methods for identification of functional cell states
Pirone et al. Beyond fluorescence: advances in computational label-free full specificity in 3D quantitative phase microscopy
Ahmed et al. Morphometric measurements of blood cell
KR20250048569A (ko) 이미징 기반 마이크로오가노스피어 약물 분석
Charrasse et al. Quantitative assessment of mitochondrial morphology relevant for studies on cellular health and environmental toxicity
Charrasse et al. Quantitative imaging and semiotic phenotyping of mitochondrial network morphology in live human cells
Bourn et al. Evaluation of image analysis tools for the measurement of cellular morphology
Li et al. Detection and tracking of overlapping cell nuclei for large scale mitosis analyses
Lippincott et al. High-content live-cell time-lapse imaging predicts cells about to die via apoptosis
US20050282208A1 (en) Cellular phenotype
Lee et al. Statistical file matching of flow cytometry data
Lopez-Lora et al. Surface-Enhanced Raman Spectroscopy on Gold Nanoparticle for Sperm Quality Discrimination
HK1231553B (en) Identification of functional cell states
US20230137843A1 (en) Holographic video microscopy cell viability assay
US20070082327A1 (en) Cellular phenotype
US20050014131A1 (en) Methods and apparatus for investigating side effects
Savatier et al. Monitoring cell cycle distributions in living cells by videomicrofluorometry and discriminant factorial analysis
Forsgren et al. The time dimension matters: Improving mode of action classification with live-cell imaging
US20240378908A1 (en) Computer-implemented method and corresponding apparatus for identifying subcellular structures in the non-chemical staining mode from phase contrast tomography reconstructions in flow cytometry
Almagwashi Label-free detection of cell-cycling polyploid cells in osteosarcoma
CN108267571A (zh) 一种血液种属判别的方法
Higgins et al. VECTR-Clasp: An open machine-learning and vector-based framework for objective quantification of motor dysfunction during hind-limb clasping in Cdkl5-deficient mice
Kannan et al. Density-Aware Spatial Randomization (DenSR) Generates Realistic Null Models for Object-Based Colocalization Analysis