ES2719615T3 - Estructura de colector hidráulico compacto para fluidos sensibles a cizalladura - Google Patents
Estructura de colector hidráulico compacto para fluidos sensibles a cizalladura Download PDFInfo
- Publication number
- ES2719615T3 ES2719615T3 ES13765553T ES13765553T ES2719615T3 ES 2719615 T3 ES2719615 T3 ES 2719615T3 ES 13765553 T ES13765553 T ES 13765553T ES 13765553 T ES13765553 T ES 13765553T ES 2719615 T3 ES2719615 T3 ES 2719615T3
- Authority
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- Spain
- Prior art keywords
- channel
- channels
- fluid
- microfluidic device
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000012530 fluid Substances 0.000 title claims abstract description 84
- 239000008280 blood Substances 0.000 claims abstract description 66
- 210000004369 blood Anatomy 0.000 claims abstract description 66
- 239000012528 membrane Substances 0.000 claims abstract description 14
- 238000001914 filtration Methods 0.000 claims abstract description 4
- 230000000295 complement effect Effects 0.000 claims abstract description 3
- 239000000758 substrate Substances 0.000 claims description 50
- 239000010410 layer Substances 0.000 description 42
- 239000000706 filtrate Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 5
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
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- 206010018910 Haemolysis Diseases 0.000 description 1
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- 230000001154 acute effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229920000229 biodegradable polyester Polymers 0.000 description 1
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- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 229910002090 carbon oxide Inorganic materials 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
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- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc oxide Inorganic materials [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1631—Constructional aspects thereof having non-tubular membranes, e.g. sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/005—Microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/082—Flat membrane modules comprising a stack of flat membranes
- B01D63/084—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes
- B01D63/085—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes specially adapted for two fluids in mass exchange flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D1/00—Pipe-line systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/08—Flow guidance means within the module or the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/10—Specific supply elements
- B01D2313/105—Supply manifolds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2319/00—Membrane assemblies within one housing
- B01D2319/04—Elements in parallel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/794—With means for separating solid material from the fluid
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Cardiology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- External Artificial Organs (AREA)
- Water Supply & Treatment (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/604,256 US9421315B2 (en) | 2012-09-05 | 2012-09-05 | Compact hydraulic manifold structure for shear sensitive fluids |
| PCT/US2013/057842 WO2014039441A1 (en) | 2012-09-05 | 2013-09-03 | Compact hydraulic manifold structure for shear sensitive fluids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2719615T3 true ES2719615T3 (es) | 2019-07-11 |
Family
ID=49223860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13765553T Active ES2719615T3 (es) | 2012-09-05 | 2013-09-03 | Estructura de colector hidráulico compacto para fluidos sensibles a cizalladura |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9421315B2 (enExample) |
| EP (1) | EP2892585B1 (enExample) |
| JP (1) | JP6614974B2 (enExample) |
| ES (1) | ES2719615T3 (enExample) |
| WO (1) | WO2014039441A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10702647B2 (en) * | 2015-03-10 | 2020-07-07 | Viatar LLC | Systems, methods, and devices for removing circulating tumor cells from blood |
| EP3411150A2 (en) | 2016-02-04 | 2018-12-12 | Massachusetts Institute of Technology | Modular organ microphysiological system with integrated pumping, leveling, and sensing |
| EP3463664A1 (en) | 2016-06-06 | 2019-04-10 | The Charles Stark Draper Laboratory, Inc. | Systems and methods for cell transduction |
| JP6919215B2 (ja) * | 2017-02-17 | 2021-08-18 | ソニーグループ株式会社 | マイクロチップ及び微小粒子分取装置 |
| US12065635B2 (en) | 2018-03-19 | 2024-08-20 | Massachusetts Institute Of Technology | Organ-on-chip platforms with reduced fluid volume |
| BR112021000996A2 (pt) * | 2018-07-19 | 2021-04-20 | Platelet Biogenesis, Inc. | biorreator de recirculação empilhado |
| US11255841B2 (en) * | 2018-08-03 | 2022-02-22 | Nano2Cure Ltd. | Distributed fluid-flow systems with equalized flow rate |
| EP3646903A1 (en) * | 2018-10-29 | 2020-05-06 | Centre National De La Recherche Scientifique | Microfluidic gas exchange devices and methods for making them |
| US20230091557A1 (en) * | 2021-09-20 | 2023-03-23 | The Charles Stark Draper Laboratory, Inc. | Respiratory assist and fluid removal device for treatment of respiratory distress syndrome |
| US12303630B2 (en) | 2022-07-25 | 2025-05-20 | William M. Gosney | Apparatus utilizing electric field for processing of blood to neutralize pathogen cells therein |
| US20240024557A1 (en) * | 2022-07-25 | 2024-01-25 | William M. Gosney | Cassette apparatus for processing of blood to neutralize pathogen cells therein |
| US12685809B2 (en) | 2022-07-25 | 2026-07-21 | William M. Gosney | Cassette apparatus utilizing electric energy for processing of blood to neutralize pathogen cells therein |
| US12678549B2 (en) | 2022-07-25 | 2026-07-14 | William M. Gosney | Method of operation utilizing electric energy for processing of blood to neutralize pathogen cells therein |
| US12544497B2 (en) | 2022-07-25 | 2026-02-10 | Blood Image Technology Llc | Method of operation utilizing electric field for processing of blood to neutralize pathogen cells therein |
| US12514969B2 (en) | 2022-07-25 | 2026-01-06 | William M. Gosney | Method of operation for processing of blood to neutralize pathogen cells therein |
| US12508355B2 (en) | 2022-07-25 | 2025-12-30 | Blood Image Technology Llc | Apparatus utilizing electric energy for processing of blood to neutralize pathogen cells therein |
| US12467844B2 (en) | 2022-07-25 | 2025-11-11 | William M. Gosney | Method of operation utilizing venting for processing of blood to remove pathogen cells therein |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2734224A (en) | 1956-02-14 | winstead | ||
| US3074559A (en) * | 1958-03-17 | 1963-01-22 | Savino Martino Francisco | Dialyzer chamber with capillary system |
| DE6801138U (de) | 1968-10-04 | 1969-03-20 | J Dr Med Hoeltzenbein | Dialysator |
| US3585131A (en) * | 1969-04-24 | 1971-06-15 | Becton Dickinson Co | Pleated memberane exchange device |
| US3695445A (en) * | 1969-04-24 | 1972-10-03 | Becton Dickinson Co | Pleated membrane transfer device |
| JPS521195Y2 (enExample) * | 1971-10-07 | 1977-01-12 | ||
| US4038191A (en) * | 1975-10-14 | 1977-07-26 | Davis Harold R | Manifold for ultra filtration machine |
| US4110220A (en) * | 1976-10-18 | 1978-08-29 | Lavender Ardis R | Mass transfer device |
| US4980068A (en) * | 1983-08-15 | 1990-12-25 | Lavender Ardis R | System, apparatus and method for continuously fractionating blood in situ |
| US4980054A (en) * | 1983-08-15 | 1990-12-25 | Lavender Ardis R | System and method for mass transfer between fluids |
| US6601613B2 (en) * | 1998-10-13 | 2003-08-05 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
| US7316780B1 (en) * | 1999-01-29 | 2008-01-08 | Pall Corporation | Range separation devices and processes |
| US7759113B2 (en) | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
| DE19961257C2 (de) | 1999-12-18 | 2002-12-19 | Inst Mikrotechnik Mainz Gmbh | Mikrovermischer |
| US7776021B2 (en) * | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
| WO2002053193A2 (en) | 2001-01-02 | 2002-07-11 | The Charles Stark Draper Laboratory, Inc. | Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology |
| AU2003213071A1 (en) * | 2002-02-13 | 2003-09-04 | Nanostream, Inc. | Microfluidic separation column devices and fabrication methods |
| US8147562B2 (en) | 2002-09-23 | 2012-04-03 | The General Hospital Corporation | Three dimensional construct for the design and fabrication of physiological fluidic networks |
| US8828226B2 (en) * | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
| US20050020557A1 (en) | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors |
| EP1547676A1 (en) * | 2003-12-24 | 2005-06-29 | Corning Incorporated | Porous membrane microstructure devices and methods of manufacture |
| CN101084054B (zh) | 2004-10-06 | 2012-03-21 | 俄勒冈州，由高等教育州委员会代表俄勒冈州立大学 | Mecs透析器 |
| CA2661221C (en) | 2006-08-24 | 2014-03-18 | Fresenius Medical Care Holdings, Inc. | Device for removing fluid from blood in a patient |
| EP3473093B1 (en) * | 2007-04-12 | 2020-10-28 | The General Hospital Corporation | Biomimetic vascular network |
| US8266791B2 (en) | 2007-09-19 | 2012-09-18 | The Charles Stark Draper Laboratory, Inc. | Method of fabricating microfluidic structures for biomedical applications |
| US8188416B2 (en) * | 2008-01-14 | 2012-05-29 | The Charles Stark Draper Laboratory, Inc. | Engineered phantoms for perfusion imaging applications |
| KR101767125B1 (ko) | 2008-06-06 | 2017-08-10 | 바이오나노 제노믹스, 인크. | 통합 나노유체 분석 장치, 제작 방법 및 분석 기술 |
| US20100125235A1 (en) * | 2008-06-16 | 2010-05-20 | Triaxis Medical Devices, Inc. | Blood Treatment Apparatus Having Branched Flow Distribution |
| US8801922B2 (en) * | 2009-06-24 | 2014-08-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Dialysis system |
| WO2011059786A1 (en) | 2009-10-29 | 2011-05-19 | The Charles Stark Draper Laboratory, Inc. | Microfluidic device for blood dialysis |
| EP2576026A1 (en) | 2010-05-26 | 2013-04-10 | The Charles Stark Draper Laboratory, Inc. | Microfabricated artificial lung assist device, and methods of use and manufacture thereof |
-
2012
- 2012-09-05 US US13/604,256 patent/US9421315B2/en active Active
-
2013
- 2013-09-03 EP EP13765553.6A patent/EP2892585B1/en active Active
- 2013-09-03 ES ES13765553T patent/ES2719615T3/es active Active
- 2013-09-03 JP JP2015531144A patent/JP6614974B2/ja active Active
- 2013-09-03 WO PCT/US2013/057842 patent/WO2014039441A1/en not_active Ceased
-
2016
- 2016-04-08 US US15/094,623 patent/US10071193B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015529155A (ja) | 2015-10-05 |
| EP2892585B1 (en) | 2019-01-09 |
| EP2892585A1 (en) | 2015-07-15 |
| WO2014039441A1 (en) | 2014-03-13 |
| JP6614974B2 (ja) | 2019-12-04 |
| US10071193B2 (en) | 2018-09-11 |
| US20140061115A1 (en) | 2014-03-06 |
| US9421315B2 (en) | 2016-08-23 |
| US20160220961A1 (en) | 2016-08-04 |
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