ES2688551T3 - Régimen de dosificación del compuesto FGF-18 - Google Patents

Régimen de dosificación del compuesto FGF-18 Download PDF

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Publication number
ES2688551T3
ES2688551T3 ES15707076.4T ES15707076T ES2688551T3 ES 2688551 T3 ES2688551 T3 ES 2688551T3 ES 15707076 T ES15707076 T ES 15707076T ES 2688551 T3 ES2688551 T3 ES 2688551T3
Authority
ES
Spain
Prior art keywords
fgf
compound
cartilage
use according
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES15707076.4T
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English (en)
Spanish (es)
Inventor
Christoph H. Ladel
Hans Guehring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of ES2688551T3 publication Critical patent/ES2688551T3/es
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2006IL-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES15707076.4T 2014-02-20 2015-02-20 Régimen de dosificación del compuesto FGF-18 Active ES2688551T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14000600 2014-02-20
EP14000600 2014-02-20
PCT/EP2015/053631 WO2015124731A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Publications (1)

Publication Number Publication Date
ES2688551T3 true ES2688551T3 (es) 2018-11-05

Family

ID=50151088

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15707076.4T Active ES2688551T3 (es) 2014-02-20 2015-02-20 Régimen de dosificación del compuesto FGF-18
ES15706006.2T Active ES2689071T3 (es) 2014-02-20 2015-02-20 Régimen de dosificación del compuesto FGF-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15706006.2T Active ES2689071T3 (es) 2014-02-20 2015-02-20 Régimen de dosificación del compuesto FGF-18

Country Status (25)

Country Link
US (2) US9724388B2 (cg-RX-API-DMAC7.html)
EP (2) EP3119417B1 (cg-RX-API-DMAC7.html)
JP (2) JP6431083B2 (cg-RX-API-DMAC7.html)
KR (2) KR102410988B1 (cg-RX-API-DMAC7.html)
CN (2) CN106232622A (cg-RX-API-DMAC7.html)
AR (2) AR099558A1 (cg-RX-API-DMAC7.html)
AU (2) AU2015220777B2 (cg-RX-API-DMAC7.html)
BR (2) BR112016018685A2 (cg-RX-API-DMAC7.html)
CA (2) CA2938793A1 (cg-RX-API-DMAC7.html)
DK (2) DK3107559T3 (cg-RX-API-DMAC7.html)
ES (2) ES2688551T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20181572T1 (cg-RX-API-DMAC7.html)
HU (1) HUE040350T2 (cg-RX-API-DMAC7.html)
IL (2) IL247083B (cg-RX-API-DMAC7.html)
LT (2) LT3119417T (cg-RX-API-DMAC7.html)
MX (2) MX2016010872A (cg-RX-API-DMAC7.html)
NZ (2) NZ723148A (cg-RX-API-DMAC7.html)
PL (2) PL3119417T3 (cg-RX-API-DMAC7.html)
PT (2) PT3119417T (cg-RX-API-DMAC7.html)
RS (2) RS57853B1 (cg-RX-API-DMAC7.html)
RU (2) RU2700582C2 (cg-RX-API-DMAC7.html)
SG (2) SG11201606502YA (cg-RX-API-DMAC7.html)
SI (2) SI3119417T1 (cg-RX-API-DMAC7.html)
WO (2) WO2015124731A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201605547B (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3107592T (pt) 2014-02-20 2018-12-03 Merck Patent Gmbh Implante que compreende fgf-18
HRP20181572T1 (hr) 2014-02-20 2018-11-30 Merck Patent Gmbh Režim doziranja spoja fgf-18
EP3250925B1 (en) 2015-01-29 2019-04-10 Ares Trading S.A. Immunoassays for highly positively charged proteins
KR20180115270A (ko) 2016-02-22 2018-10-22 노파르티스 아게 Fxr 효능제를 사용하는 방법
HRP20220737T1 (hr) 2017-09-29 2022-09-02 Merck Patent Gmbh Upalni biomarkeri za predviđanje odgovaranja na spoj fgf-18
US11513128B2 (en) 2017-09-29 2022-11-29 Merck Patent Gmbh Metabolic biomarkers for predicting responsiveness to FGF-18 compound
HRP20240665T1 (hr) 2018-09-10 2024-08-16 Merck Patent Gmbh Markeri korisni u strategijama obogaćivanja za liječenje osteoartritisa
EP3920959A1 (en) * 2019-02-08 2021-12-15 Merck Patent GmbH Treatment of patients at risk of rapid progression of osteoarthritis
WO2025077768A1 (en) * 2023-10-11 2025-04-17 Sichuan Real & Best Biotech Co., Ltd. Compositions and methods for treating arthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2500742C (en) * 2002-10-07 2014-02-18 Zymogenetics, Inc. Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis
US20060009389A1 (en) 2004-07-06 2006-01-12 Moore Emma E Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
WO2007070983A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents
BRPI0715728A8 (pt) * 2006-08-25 2018-04-03 Ares Trading Sa tratamento de distúrbios cartilaginosos
EA015644B1 (ru) * 2006-08-25 2011-10-31 Арес Трейдинг С.А. Способ лечения заболеваний хряща
DE102006043260A1 (de) * 2006-09-11 2008-03-27 Krones Ag Etikettieranlage
JP6277121B2 (ja) * 2011-03-22 2018-02-07 アドヴィナス・セラピューティックス・リミテッド 置換された縮合三環式化合物、その組成物および医学的応用
PT3107592T (pt) 2014-02-20 2018-12-03 Merck Patent Gmbh Implante que compreende fgf-18
KR102437057B1 (ko) 2014-02-20 2022-08-26 메르크 파텐트 게엠베하 이식편 이식 및 조직 공학 절차에 있어서의 fgf-18
HRP20181572T1 (hr) 2014-02-20 2018-11-30 Merck Patent Gmbh Režim doziranja spoja fgf-18

Also Published As

Publication number Publication date
AR099510A1 (es) 2016-07-27
BR112016018696A2 (pt) 2017-10-17
KR20160116000A (ko) 2016-10-06
RU2691946C2 (ru) 2019-06-19
DK3107559T3 (en) 2018-10-15
KR102410986B1 (ko) 2022-06-17
WO2015124731A1 (en) 2015-08-27
RU2016137292A (ru) 2018-03-21
US9724388B2 (en) 2017-08-08
LT3119417T (lt) 2018-10-25
EP3119417A1 (en) 2017-01-25
LT3107559T (lt) 2018-10-25
SI3119417T1 (sl) 2018-11-30
IL247084B (en) 2019-09-26
RU2700582C2 (ru) 2019-09-18
DK3119417T3 (en) 2018-10-22
WO2015124727A1 (en) 2015-08-27
KR20160116001A (ko) 2016-10-06
RU2016137292A3 (cg-RX-API-DMAC7.html) 2018-09-17
CA2938793A1 (en) 2015-08-27
IL247083A0 (en) 2016-09-29
JP6431082B2 (ja) 2018-11-28
AU2015220773B2 (en) 2020-10-08
AU2015220777A1 (en) 2016-09-01
IL247083B (en) 2019-09-26
PT3107559T (pt) 2018-10-31
AU2015220777B2 (en) 2020-10-22
PL3107559T3 (pl) 2019-01-31
CN106232622A (zh) 2016-12-14
US20170072017A1 (en) 2017-03-16
JP6431083B2 (ja) 2018-11-28
AU2015220773A1 (en) 2016-09-01
JP2017512194A (ja) 2017-05-18
SI3107559T1 (sl) 2018-11-30
PL3119417T3 (pl) 2019-01-31
EP3107559A1 (en) 2016-12-28
AR099558A1 (es) 2016-08-03
IL247084A0 (en) 2016-09-29
RS57709B1 (sr) 2018-12-31
US9889179B2 (en) 2018-02-13
NZ723139A (en) 2022-12-23
BR112016018685A2 (pt) 2017-10-17
CN106456713A (zh) 2017-02-22
RU2016137289A3 (cg-RX-API-DMAC7.html) 2018-10-19
MX2016010871A (es) 2016-11-17
JP2017507142A (ja) 2017-03-16
RU2016137289A (ru) 2018-03-21
EP3107559B1 (en) 2018-07-11
RS57853B1 (sr) 2018-12-31
CA2938791A1 (en) 2015-08-27
NZ723148A (en) 2022-08-26
ZA201605547B (en) 2019-09-25
PT3119417T (pt) 2018-10-31
EP3119417B1 (en) 2018-07-11
ZA201605548B (en) 2018-12-19
HUE040350T2 (hu) 2019-03-28
SG11201606505UA (en) 2016-09-29
KR102410988B1 (ko) 2022-06-17
MX2016010872A (es) 2016-11-17
SG11201606502YA (en) 2016-09-29
HRP20181572T1 (hr) 2018-11-30
US20170056474A1 (en) 2017-03-02
HRP20181570T1 (hr) 2018-11-30
ES2689071T3 (es) 2018-11-08

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