ES2684368T3 - Derivados del nucleósido uridina, composiciones y métodos de uso - Google Patents

Derivados del nucleósido uridina, composiciones y métodos de uso Download PDF

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ES2684368T3
ES2684368T3 ES14775026T ES14775026T ES2684368T3 ES 2684368 T3 ES2684368 T3 ES 2684368T3 ES 14775026 T ES14775026 T ES 14775026T ES 14775026 T ES14775026 T ES 14775026T ES 2684368 T3 ES2684368 T3 ES 2684368T3
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Philip G. Haydon
Jinbo Lee
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Abstract

Una composición farmacéutica que comprende un compuesto de fórmula I:**Fórmula** o una sal del mismo, en el que: A es un anillo aromático bicíclico (C5-C10) que tiene hasta 4 heteroátomos seleccionados entre N, O y S, en el que el anillo aromático está independientemente y opcionalmente sustituido con uno o más R7; X se selecciona de: -H, -C(O)R5, -C(O)OR5, y -P(O)(OR5)2; Y es un enlace o un grupo alifático (C1-C5) independientemente y opcionalmente sustituido con uno o más R4; Z y W se seleccionan cada uno independientemente de >=O, >=S, >=N(R5), y >=NOR5; R1 se selecciona de: -H, halógeno, -OR5, -CN, -CF3, -OCF3 y un grupo alifático (C1-C6) opcionalmente sustituido con uno o más R7; R2 y R3 se seleccionan cada uno independientemente de -OR5, -SR5, -NR5R6, -OC(O)R5, -OC(O)NR5R6, y -OC(O)OR5; cada aparición de R4 se selecciona independientemente de: halógeno, -OR5, -NO2, -CN, -CF3, -OCF3, -R5, 1,2-metilendioxi, 1,2-etilendioxi, -N(R5)2, -SR5, -SOR5, -SO2R5, - SO2N(R5)2, -SO3R5, -C(O)R5, -C(O)C(O)R5, -C(O)CH2C(O)R5, -C(S)R5, -C(S)OR5, -C(O)OR5, -C(O)C(O)OR5, - C(O)C(O)N(R5)2, -OC(O)R5, -C(O)N(R5)2, -OC(O)N(R5)2, -C(S)N(R5)2, -(CH2)0-2NHC(O)R5, -N(R5)N(R5)COR5, - N(R5)N(R5)C(O)OR5, -N(R5)N(R5)CON(R5)2, -N(R5)SO2R5, -N(R5)SO2N(R5)2, -N(R5)C(O)OR5, -N(R5)C(O)R5, - N(R5)C(S)R5, -N(R5)C(O)N(R5)2, -N(R5)C(S)N(R5)2, -N(COR5)COR5, -N(OR5)R5, -C(>=NH)N(R5)2, -C(O)N(OR5)R5, - C(>=NOR5)R5, -OP(O)(OR5)2, -P(O)(R5)2, -P(O)(OR5)2, o -P(O)(H)(OR5); cada aparición de R5 se selecciona independientemente de: H-, (C1-C12)-alifático-, (C3-C10)-cicloalquil- o -cicloalquenil-, [(C3-C10)-cicloalquil o -cicloalquenil]-(C1-C12)-alifático-, (C6-C10)-aril-, (C6-C10)-aril-(C1-C12)alifático-, (C3-C10)-heterociclil-, (C6-C10)-heterociclil-(C1-C12)alifático-, (C5-C10)-heteroaril-, y (C5-C10)-heteroaril-(C1-C12)-alifático-; en la que dos grupos R5 unidos al mismo átomo forman opcionalmente un anillo aromático o no aromático de 3 a 10 miembros que tiene hasta 3 heteroátomos seleccionados independientemente de N, O, S, SO o SO2, en la que dicho anillo está opcionalmente fusionado a un arilo (C6-C10), heteroarilo (C5-C10), cicloalquilo (C3-C10), o un heterociclilo (C3-C10); y en la que cada grupo R5 está independientemente y opcionalmente sustituido con uno o más R7; R6 se selecciona de: -R5, -C(O)R5, -C(O)OR5, -C(O)N(R5)2 y -S(O)2R5; cada aparición de R7 se selecciona independientemente de: halógeno, -OR8, -NO2, -CN, -CF3, -OCF3, -R8, oxo, tioxo, 1,2-metilendioxi, 1,2-etilendioxi, -N(R8)2, -SR8, -SOR8, -SO2 R8, -SO2N(R8)2, -SO3R8, -C(O)R8, -C(O)C(O)R8, -C(O)CH2C(O)R8, -C(S)R8, -C(S)OR8, -C(O)OR8, -C(O)C(O)OR8, - C(O)C(O)N(R8)2, -OC(O)R8, -C(O)N(R8)2, -OC(O)N(R8)2, -C(S)N(R8)2, -(CH2)0-2NHC(O)R8, -N(R8)N(R8)COR8, - N(R8)N(R8)C(O)OR8, -N(R8)N(R8)CON(R8)2, -N(R8)SO2R8, -N(R8)SO2N(R8)2, -N(R8)C(O)OR8, -N(R8)C(O)R8, - N(R8)C(S)R8, -N(R8)C(O)N(R8)2, -N(R8)C(S)N(R8)2, -N(COR8)COR8, -N(OR8)R8, -C(>=NH)N(R8)2, -C(O)N(OR8)R8, - C(>=NOR8)R8, -OP(O)(OR8)2, -P(O)(R8)2, -P( O)(OR8)2, o -P(O)(H)(OR8); cada aparición de R8 se selecciona independientemente de: H- y (C1-C6)-alifático- ; y un portador, adyuvante o excipiente farmacéuticamente aceptable.
ES14775026T 2013-03-13 2014-03-13 Derivados del nucleósido uridina, composiciones y métodos de uso Active ES2684368T3 (es)

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AR095442A1 (es) 2013-03-13 2015-10-14 Univ Tufts Derivados de nucleósido de uridina, composiciones y métodos de uso
DK2968385T3 (en) 2013-03-13 2018-09-03 Univ Tufts URIDINNUCLEOSIDE DERIVATIVES, COMPOSITIONS AND PROCEDURES FOR USING THEREOF
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