ES2674993T3 - Derivados de 5-amino-quinolina-8-carboxamida como agonistas del receptor 5-HT4 - Google Patents
Derivados de 5-amino-quinolina-8-carboxamida como agonistas del receptor 5-HT4 Download PDFInfo
- Publication number
- ES2674993T3 ES2674993T3 ES13811624.9T ES13811624T ES2674993T3 ES 2674993 T3 ES2674993 T3 ES 2674993T3 ES 13811624 T ES13811624 T ES 13811624T ES 2674993 T3 ES2674993 T3 ES 2674993T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- quinolin
- carboxamide
- amino
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091005482 5-HT4 receptors Proteins 0.000 title claims description 16
- 239000000018 receptor agonist Substances 0.000 title claims description 10
- 229940044601 receptor agonist Drugs 0.000 title claims description 10
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- 150000001875 compounds Chemical class 0.000 claims abstract description 179
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- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 3
- 229910052731 fluorine Chemical group 0.000 claims abstract description 3
- 239000011737 fluorine Chemical group 0.000 claims abstract description 3
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1199CH2013 | 2013-03-20 | ||
| PCT/IN2013/000639 WO2014147636A1 (en) | 2013-03-20 | 2013-10-18 | 5-amino-quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists |
| IN1199CH2013 IN2013CH01199A (cg-RX-API-DMAC7.html) | 2013-03-20 | 2013-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2674993T3 true ES2674993T3 (es) | 2018-07-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13811624.9T Active ES2674993T3 (es) | 2013-03-20 | 2013-10-18 | Derivados de 5-amino-quinolina-8-carboxamida como agonistas del receptor 5-HT4 |
Country Status (18)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3265459T (pt) * | 2015-02-13 | 2019-07-17 | Suven Life Sciences Ltd | Compostos amidos como agonistas do recetor 5-ht4 |
| CN109444301A (zh) * | 2018-12-18 | 2019-03-08 | 江苏省中医院 | 一种测定血浆中普芦卡必利浓度的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08502273A (ja) * | 1992-10-13 | 1996-03-12 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ▲下４▼レセプターアンタゴニスト用複素環式エステルまたはアミド |
| AU680453B2 (en) | 1992-11-05 | 1997-07-31 | Smithkline Beecham Plc | Piperidine derivatives as 5-HT4 receptor antagonists |
| FR2756564B1 (fr) * | 1996-12-04 | 2004-05-14 | Synthelabo | Derives d'acide quinoleine-8-carboxylique, leur preparation et leur application en therapeutique |
| AU2001225664A1 (en) * | 2000-06-15 | 2001-12-24 | Respiratorius Ab | 5-ht3 receptor antagonists for treatment of disorders involving airway constriction |
| PT1638959E (pt) | 2003-06-19 | 2007-12-12 | Janssen Pharmaceutica Nv | 4-(aminometil)piperidinobenzamidas antagonistas de 5ht4 |
| ES2338882T3 (es) | 2003-11-24 | 2010-05-13 | Pfizer, Inc. | Compuestos de acido quinolona-carboxilico que tienen actividad agonista del receptor 5-ht4. |
| EP1701951B1 (en) * | 2003-12-23 | 2010-02-10 | Serodus AS | Modulators of peripheral 5-ht receptors |
| WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
| WO2006090224A1 (en) | 2005-02-25 | 2006-08-31 | Pfizer Japan Inc. | Benzisoxazole derivatives |
| DE602006010563D1 (de) | 2005-07-22 | 2009-12-31 | Pfizer | Indazolcarbonsäureamidderivate als agonisten des 5ht4-rezeptors |
| GB0525661D0 (en) * | 2005-12-16 | 2006-01-25 | Glaxo Group Ltd | Novel compounds |
| BR112012020060B8 (pt) * | 2010-02-12 | 2021-05-25 | Askat Inc | uso de n-((1-((4-hidroxitetrahidro-2h-piran-4-il)metil)piperidin-4-il)metil)-3-isopropil-2-oxo-2,3-dihidro-1h-benzo[d]imidazol-1-carboxamida para tratar doença de alzheimer e demência |
| JP2013519722A (ja) | 2010-02-16 | 2013-05-30 | ファイザー・インク | （ｒ）−４−（（４−（（４−（テトラヒドロフラン−３−イルオキシ）ベンゾ［ｄ］イソオキサゾール−３−イルオキシ）メチル）ピペリジン−１−イル）メチル）テトラヒドロ−２ｈ−ピラン−４−オール、５−ｈｔ４受容体の部分アゴニスト |
-
2013
- 2013-10-18 AU AU2013382944A patent/AU2013382944B2/en not_active Ceased
- 2013-10-18 NZ NZ712369A patent/NZ712369A/en not_active IP Right Cessation
- 2013-10-18 IN IN1199CH2013 patent/IN2013CH01199A/en unknown
- 2013-10-18 BR BR112015024060A patent/BR112015024060A2/pt not_active IP Right Cessation
- 2013-10-18 EP EP13811624.9A patent/EP2976337B1/en active Active
- 2013-10-18 AP AP2015008742A patent/AP2015008742A0/xx unknown
- 2013-10-18 CA CA2907620A patent/CA2907620C/en not_active Expired - Fee Related
- 2013-10-18 CN CN201380074877.9A patent/CN105164119B/zh not_active Expired - Fee Related
- 2013-10-18 DK DK13811624.9T patent/DK2976337T3/en active
- 2013-10-18 EA EA201591844A patent/EA029365B1/ru not_active IP Right Cessation
- 2013-10-18 WO PCT/IN2013/000639 patent/WO2014147636A1/en not_active Ceased
- 2013-10-18 MX MX2015012350A patent/MX364929B/es active IP Right Grant
- 2013-10-18 ES ES13811624.9T patent/ES2674993T3/es active Active
- 2013-10-18 JP JP2016504852A patent/JP6185650B2/ja not_active Expired - Fee Related
- 2013-10-18 US US14/777,925 patent/US9790211B2/en not_active Expired - Fee Related
- 2013-10-18 KR KR1020157030158A patent/KR101815307B1/ko not_active Expired - Fee Related
- 2013-10-18 SG SG11201507763RA patent/SG11201507763RA/en unknown
-
2015
- 2015-09-14 ZA ZA2015/06804A patent/ZA201506804B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014147636A8 (en) | 2014-12-04 |
| US9790211B2 (en) | 2017-10-17 |
| CA2907620A1 (en) | 2014-09-25 |
| SG11201507763RA (en) | 2015-10-29 |
| AP2015008742A0 (en) | 2015-09-30 |
| EP2976337B1 (en) | 2018-05-02 |
| AU2013382944B2 (en) | 2016-08-04 |
| CA2907620C (en) | 2018-03-13 |
| NZ712369A (en) | 2016-11-25 |
| WO2014147636A1 (en) | 2014-09-25 |
| US20160280694A1 (en) | 2016-09-29 |
| EA201591844A1 (ru) | 2016-08-31 |
| HK1217483A1 (zh) | 2017-01-13 |
| MX2015012350A (es) | 2016-05-09 |
| CN105164119B (zh) | 2017-12-08 |
| KR101815307B1 (ko) | 2018-01-04 |
| AU2013382944A1 (en) | 2015-10-08 |
| IN2013CH01199A (cg-RX-API-DMAC7.html) | 2015-08-14 |
| EA029365B1 (ru) | 2018-03-30 |
| BR112015024060A2 (pt) | 2017-07-18 |
| DK2976337T3 (en) | 2018-07-16 |
| MX364929B (es) | 2019-05-14 |
| JP2016516089A (ja) | 2016-06-02 |
| CN105164119A (zh) | 2015-12-16 |
| ZA201506804B (en) | 2016-07-27 |
| KR20160004274A (ko) | 2016-01-12 |
| EP2976337A1 (en) | 2016-01-27 |
| JP6185650B2 (ja) | 2017-08-23 |
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