ES2674361T3 - Combinación de un inhibidor de ALK y un inhibidor de CDK para el tratamiento de enfermedades celulares proliferativas - Google Patents

Combinación de un inhibidor de ALK y un inhibidor de CDK para el tratamiento de enfermedades celulares proliferativas Download PDF

Info

Publication number
ES2674361T3
ES2674361T3 ES14766301.7T ES14766301T ES2674361T3 ES 2674361 T3 ES2674361 T3 ES 2674361T3 ES 14766301 T ES14766301 T ES 14766301T ES 2674361 T3 ES2674361 T3 ES 2674361T3
Authority
ES
Spain
Prior art keywords
compound
combination
alk
agent
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14766301.7T
Other languages
English (en)
Spanish (es)
Inventor
Jennifer Leslie Harris
Nanxin LI
Timothy R. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2674361T3 publication Critical patent/ES2674361T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES14766301.7T 2013-08-28 2014-08-28 Combinación de un inhibidor de ALK y un inhibidor de CDK para el tratamiento de enfermedades celulares proliferativas Active ES2674361T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361871275P 2013-08-28 2013-08-28
US201361871275P 2013-08-28
PCT/US2014/053244 WO2015031666A1 (en) 2013-08-28 2014-08-28 Combination of an alk inhibitor and a cdk inhibitor for the treatment of cell proliferative diseases

Publications (1)

Publication Number Publication Date
ES2674361T3 true ES2674361T3 (es) 2018-06-29

Family

ID=51541330

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14766301.7T Active ES2674361T3 (es) 2013-08-28 2014-08-28 Combinación de un inhibidor de ALK y un inhibidor de CDK para el tratamiento de enfermedades celulares proliferativas

Country Status (12)

Country Link
US (2) US20160361314A1 (cg-RX-API-DMAC7.html)
EP (1) EP3038652B1 (cg-RX-API-DMAC7.html)
JP (1) JP6479812B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160047521A (cg-RX-API-DMAC7.html)
CN (1) CN106029099A (cg-RX-API-DMAC7.html)
AU (3) AU2014312261A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016004358A8 (cg-RX-API-DMAC7.html)
CA (1) CA2922684A1 (cg-RX-API-DMAC7.html)
ES (1) ES2674361T3 (cg-RX-API-DMAC7.html)
MX (1) MX2016002580A (cg-RX-API-DMAC7.html)
RU (1) RU2016110874A (cg-RX-API-DMAC7.html)
WO (1) WO2015031666A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016167511A2 (ko) * 2015-04-14 2016-10-20 한국화학연구원 N2-(2-메톡시페닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
KR101772134B1 (ko) 2015-04-14 2017-08-29 한국화학연구원 N2-(2-메톡시페닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
US11208630B2 (en) * 2015-12-24 2021-12-28 University Of Florida Research Foundation, Incorporated AAV production using suspension adapted cells
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
MY205589A (en) 2018-01-08 2024-10-28 G1 Therapeutics Inc G1t38 superior dosage regimes
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
AU2020256220A1 (en) * 2019-04-04 2021-09-16 Dana-Farber Cancer Institute, Inc. CDK2/5 degraders and uses thereof
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
AU2020389184A1 (en) 2019-11-18 2022-06-02 Chugai Seiyaku Kabushiki Kaisha Combination drug
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20230117684A1 (en) * 2020-03-05 2023-04-20 Pfizer Inc. Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor
WO2022063220A1 (en) * 2020-09-25 2022-03-31 Ascentage Pharma (Suzhou) Co., Ltd. A pharmaceutical composition and use thereof for treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311807B1 (en) * 2006-12-08 2015-11-11 Novartis AG Compounds and composition as protein kinase inhibitors
WO2008073687A2 (en) * 2006-12-08 2008-06-19 Irm Llc Compounds and compositions as protein kinase inhibitors
BRPI0917791B1 (pt) * 2008-08-22 2022-03-22 Novartis Ag Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação
EP3406260B1 (en) * 2009-05-13 2020-09-23 The University of North Carolina at Chapel Hill Cyclin dependent kinase inhibitors and methods of use
AU2011240735B2 (en) * 2010-04-13 2015-01-29 Novartis Ag Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase (CDK4/6) inhibitor and an mTOR inhibitor for treating cancer
MX2013008791A (es) * 2011-02-02 2013-10-07 Irm Llc Metodos para usar inhibidores de alk.

Also Published As

Publication number Publication date
JP2016529285A (ja) 2016-09-23
US20180318305A1 (en) 2018-11-08
RU2016110874A3 (cg-RX-API-DMAC7.html) 2018-06-27
AU2014312261A1 (en) 2016-03-10
EP3038652B1 (en) 2018-03-21
AU2018236813A1 (en) 2018-10-18
CN106029099A (zh) 2016-10-12
BR112016004358A8 (pt) 2020-02-11
JP6479812B2 (ja) 2019-03-06
KR20160047521A (ko) 2016-05-02
CA2922684A1 (en) 2015-03-05
US20160361314A1 (en) 2016-12-15
MX2016002580A (es) 2016-10-26
AU2017219093A1 (en) 2017-09-14
WO2015031666A1 (en) 2015-03-05
RU2016110874A (ru) 2017-10-04
EP3038652A1 (en) 2016-07-06

Similar Documents

Publication Publication Date Title
ES2674361T3 (es) Combinación de un inhibidor de ALK y un inhibidor de CDK para el tratamiento de enfermedades celulares proliferativas
CA2827673C (en) Mtor/jak inhibitor combination therapy
Akinleye et al. Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
ES2778059T3 (es) Combinaciones farmacéuticas de un inhibidor de CDK4/6 y un inhibidor de B-Raf
ES2962460T3 (es) Inhibidores de mdm2 y combinaciones de estos
ES2676177T3 (es) Una combinación farmacéutica que comprende binimetinib
KR20240167633A (ko) 종양 치료용 약학 조성물
CN105338980A (zh) 药物组合
US10328066B2 (en) Pharmaceutical combination comprising the PI3K inhibitor alpelisib and the CDK4/6 inhibitor ribociclib, and the use thereof in the treatment/prevention of cancer
JP2017214387A (ja) 増殖性疾患の治療のためのhsp90阻害剤と組み合わせた2−カルボキサミドシクロアミノウレア誘導体
CN113813268A (zh) 包含Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂的组合产品及其用途
JP2023533489A (ja) 癌併用療法におけるdhodh阻害剤化合物の利用
WO2016193955A1 (en) Combinations of kinase inhibitors for treating colorectal cancer
CN105764528A (zh) 包含jak、cdk和pim抑制剂的联合疗法
US20180318275A1 (en) Combination therapy using pi3k inhibitor and mdm2 inhibitor
JP2009532497A (ja) 癌を処置するための治療剤の組合せ
US20220354874A1 (en) Therapeutic compositions and methods for treating cancers
EP4656193A1 (en) Pharmaceutical composition for treating tumors
CN105566329A (zh) 一种吡唑[5,6-d]并嘧啶类EGFR抑制剂及其抗肿瘤活性
US20180256557A1 (en) Pharmaceutical combination comprising (a) the alpha-isoform specific pi3k inhibitor alpelisib (byl719) and (b) an akt inhibitor, preferably mk-2206, afuresertib or uprosertib, and the use thereof in the treatment/prevention of cancer