ES2663407T3 - Métodos para el tratamiento del cáncer de mama - Google Patents
Métodos para el tratamiento del cáncer de mama Download PDFInfo
- Publication number
- ES2663407T3 ES2663407T3 ES12827061.8T ES12827061T ES2663407T3 ES 2663407 T3 ES2663407 T3 ES 2663407T3 ES 12827061 T ES12827061 T ES 12827061T ES 2663407 T3 ES2663407 T3 ES 2663407T3
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- entinostat
- exemestane
- therapy
- acetylation
- combination
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Classifications
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US201161628999P | 2011-11-12 | ||
| US201161568110P | 2011-12-07 | 2011-12-07 | |
| US201161568110P | 2011-12-07 | ||
| PCT/US2012/053551 WO2013033656A1 (en) | 2011-09-02 | 2012-08-31 | Methods for the treatment of breast cancer |
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| ES2663407T3 true ES2663407T3 (es) | 2018-04-12 |
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| EP3381454A1 (en) | 2011-09-02 | 2018-10-03 | Syndax Pharmaceuticals Inc. | Methods for the treatment of breast cancer |
| WO2014179738A1 (en) * | 2013-05-03 | 2014-11-06 | Syndax Pharmaceuticals, Inc. | Methods for the treatment of cancer |
| US20180104232A1 (en) * | 2015-03-12 | 2018-04-19 | The University Of Chicago | Methods for determining prognosis for breast cancer patients |
| EP3345002A4 (en) * | 2015-09-02 | 2019-05-08 | Syndax Pharmaceuticals Inc. | SELECTION OF PATIENTS FOR COMBINATION THERAPY |
| CN109715173A (zh) | 2016-07-15 | 2019-05-03 | 维拉克塔治疗公司 | 供基于nk细胞的疗法使用的hdac抑制剂 |
| US20190282541A1 (en) * | 2016-07-20 | 2019-09-19 | Eisai R&D Management Co., Ltd. | Use of eribulin and histone deacetylase inhibitors in the treatment of cancer |
| EP3624848A1 (en) | 2017-05-19 | 2020-03-25 | Syndax Pharmaceuticals, Inc. | Combination therapies |
| CN112513636A (zh) | 2018-05-07 | 2021-03-16 | 赛达克斯制药股份有限公司 | 用于组合疗法的患者的选择 |
| KR102212699B1 (ko) | 2019-08-12 | 2021-02-05 | 한국원자력의학원 | 유방암 예방 또는 치료용 조성물 |
| US11881093B2 (en) | 2020-08-20 | 2024-01-23 | Denso International America, Inc. | Systems and methods for identifying smoking in vehicles |
| US12017506B2 (en) | 2020-08-20 | 2024-06-25 | Denso International America, Inc. | Passenger cabin air control systems and methods |
| US12251991B2 (en) | 2020-08-20 | 2025-03-18 | Denso International America, Inc. | Humidity control for olfaction sensors |
| US11760169B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Particulate control systems and methods for olfaction sensors |
| US11636870B2 (en) | 2020-08-20 | 2023-04-25 | Denso International America, Inc. | Smoking cessation systems and methods |
| US11760170B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Olfaction sensor preservation systems and methods |
| US12269315B2 (en) | 2020-08-20 | 2025-04-08 | Denso International America, Inc. | Systems and methods for measuring and managing odor brought into rental vehicles |
| US11813926B2 (en) | 2020-08-20 | 2023-11-14 | Denso International America, Inc. | Binding agent and olfaction sensor |
| US11932080B2 (en) | 2020-08-20 | 2024-03-19 | Denso International America, Inc. | Diagnostic and recirculation control systems and methods |
| US11828210B2 (en) | 2020-08-20 | 2023-11-28 | Denso International America, Inc. | Diagnostic systems and methods of vehicles using olfaction |
| US12377711B2 (en) | 2020-08-20 | 2025-08-05 | Denso International America, Inc. | Vehicle feature control systems and methods based on smoking |
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| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
| US20100092992A1 (en) * | 2006-08-17 | 2010-04-15 | Peter Hornbeck | Lysine acetylation sites |
| WO2008154382A1 (en) * | 2007-06-06 | 2008-12-18 | University Of Maryland, Baltimore | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
| WO2008154402A2 (en) * | 2007-06-06 | 2008-12-18 | University Of Maryland, Baltimore | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
| US20100305167A1 (en) * | 2007-11-19 | 2010-12-02 | Syndax Pharmaceuticals, Inc. | Administration of an Inhibitor of HDAC |
| CA2825969A1 (en) | 2011-02-02 | 2012-08-09 | Genentech, Inc. | Dosing for treatment with anti-egfl7 antibodies |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| EP3381454A1 (en) | 2011-09-02 | 2018-10-03 | Syndax Pharmaceuticals Inc. | Methods for the treatment of breast cancer |
| CH706458B1 (fr) | 2012-04-30 | 2017-05-15 | Granit Tech Sa | Procédé de cimentation pour le stockage de déchets. |
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| US20190343844A1 (en) | 2019-11-14 |
| KR101956861B1 (ko) | 2019-03-12 |
| CN103906837A (zh) | 2014-07-02 |
| KR20140108629A (ko) | 2014-09-12 |
| CN107982270A (zh) | 2018-05-04 |
| CN114053284A (zh) | 2022-02-18 |
| CA2847348A1 (en) | 2013-03-07 |
| EP3381454A1 (en) | 2018-10-03 |
| HK1254859A1 (zh) | 2019-07-26 |
| WO2013033656A1 (en) | 2013-03-07 |
| MX358254B (es) | 2018-08-10 |
| UA149007U (uk) | 2021-10-13 |
| JP6195384B2 (ja) | 2017-09-13 |
| EA201201474A1 (ru) | 2013-08-30 |
| US10226472B2 (en) | 2019-03-12 |
| AU2012301616B2 (en) | 2018-02-08 |
| MX2014002515A (es) | 2015-05-07 |
| AU2012301616A1 (en) | 2014-04-17 |
| EP2751267A4 (en) | 2015-01-07 |
| US20140378420A1 (en) | 2014-12-25 |
| EP2751267A1 (en) | 2014-07-09 |
| GEP201706612B (en) | 2017-02-10 |
| UA124239U (uk) | 2018-03-26 |
| UA124241U (uk) | 2018-03-26 |
| JP2017149761A (ja) | 2017-08-31 |
| AU2018203059A1 (en) | 2018-05-17 |
| BR112014005080A2 (pt) | 2017-03-28 |
| UA124238U (uk) | 2018-03-26 |
| UA123212U (uk) | 2018-02-26 |
| UA124240U (uk) | 2018-03-26 |
| JP2014525465A (ja) | 2014-09-29 |
| EP2751267B1 (en) | 2018-01-24 |
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