ES2661394T3 - Derivados de di- y tri-heteroarilo como inhibidores de la agregación de proteínas - Google Patents
Derivados de di- y tri-heteroarilo como inhibidores de la agregación de proteínas Download PDFInfo
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- ES2661394T3 ES2661394T3 ES13820320.3T ES13820320T ES2661394T3 ES 2661394 T3 ES2661394 T3 ES 2661394T3 ES 13820320 T ES13820320 T ES 13820320T ES 2661394 T3 ES2661394 T3 ES 2661394T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672239P | 2012-07-16 | 2012-07-16 | |
| US201261672239P | 2012-07-16 | ||
| PCT/US2013/050719 WO2014014937A1 (en) | 2012-07-16 | 2013-07-16 | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2661394T3 true ES2661394T3 (es) | 2018-03-28 |
Family
ID=49949212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13820320.3T Active ES2661394T3 (es) | 2012-07-16 | 2013-07-16 | Derivados de di- y tri-heteroarilo como inhibidores de la agregación de proteínas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9284309B2 (https=) |
| EP (1) | EP2872143B1 (https=) |
| JP (1) | JP2015522617A (https=) |
| KR (1) | KR20150031481A (https=) |
| CN (1) | CN104703604A (https=) |
| AU (1) | AU2013290361A1 (https=) |
| BR (1) | BR112015001096A2 (https=) |
| CA (1) | CA2877983A1 (https=) |
| ES (1) | ES2661394T3 (https=) |
| HK (1) | HK1210598A1 (https=) |
| IL (1) | IL236712A0 (https=) |
| IN (1) | IN2015DN01171A (https=) |
| MX (1) | MX2015000618A (https=) |
| RU (1) | RU2015104962A (https=) |
| WO (1) | WO2014014937A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA032374B1 (ru) * | 2014-01-29 | 2019-05-31 | ЮСиБи БАЙОФАРМА СПРЛ | Гетероарильные амиды в качестве ингибиторов агрегации белков |
| ES2885049T3 (es) | 2015-07-29 | 2021-12-13 | UCB Biopharma SRL | Derivados de bis-heteroarilo como moduladores de la agregación de proteínas |
| US10913735B2 (en) | 2017-01-26 | 2021-02-09 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| WO2018138085A1 (en) * | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| CN110167937B (zh) | 2017-01-26 | 2022-03-29 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的二环双-杂芳基衍生物 |
| EP3589616A1 (en) | 2017-02-28 | 2020-01-08 | Universitat Autònoma de Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019025424A1 (en) | 2017-08-04 | 2019-02-07 | Universitat Autonoma De Barcelona | COMPOUNDS FOR TREATING SYNUCLEINOPATHIES |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| CN113683598B (zh) * | 2020-05-18 | 2022-10-14 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| WO2025223458A1 (zh) * | 2024-04-23 | 2025-10-30 | 深圳众格生物科技有限公司 | 一种cyp11a1抑制剂、其制备方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2369076A1 (en) * | 2000-02-05 | 2001-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
| ATE335737T1 (de) * | 2000-09-15 | 2006-09-15 | Vertex Pharma | Isoxazole und ihre verwendung als erk-inhibitoren |
| WO2004014905A1 (en) | 2002-08-08 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
| WO2010125082A1 (en) | 2009-04-30 | 2010-11-04 | Glaxo Group Limited | Oxazole substituted indazoles as pi3-kinase inhibitors |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| NZ600449A (en) * | 2009-12-16 | 2014-10-31 | Neuropore Therapies Inc | Compound suitable for the treatment of synucleopathies |
| US9198891B2 (en) * | 2010-05-21 | 2015-12-01 | New York University | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase |
-
2013
- 2013-07-16 ES ES13820320.3T patent/ES2661394T3/es active Active
- 2013-07-16 KR KR20157004215A patent/KR20150031481A/ko not_active Withdrawn
- 2013-07-16 EP EP13820320.3A patent/EP2872143B1/en active Active
- 2013-07-16 AU AU2013290361A patent/AU2013290361A1/en not_active Abandoned
- 2013-07-16 HK HK15111382.6A patent/HK1210598A1/xx unknown
- 2013-07-16 US US14/415,120 patent/US9284309B2/en active Active
- 2013-07-16 BR BR112015001096A patent/BR112015001096A2/pt not_active Application Discontinuation
- 2013-07-16 CA CA2877983A patent/CA2877983A1/en not_active Abandoned
- 2013-07-16 CN CN201380038158.1A patent/CN104703604A/zh active Pending
- 2013-07-16 MX MX2015000618A patent/MX2015000618A/es unknown
- 2013-07-16 JP JP2015523185A patent/JP2015522617A/ja active Pending
- 2013-07-16 WO PCT/US2013/050719 patent/WO2014014937A1/en not_active Ceased
- 2013-07-16 RU RU2015104962A patent/RU2015104962A/ru not_active Application Discontinuation
-
2015
- 2015-01-14 IL IL236712A patent/IL236712A0/en unknown
- 2015-02-12 IN IN1171DEN2015 patent/IN2015DN01171A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015104962A (ru) | 2016-09-10 |
| EP2872143B1 (en) | 2017-12-13 |
| JP2015522617A (ja) | 2015-08-06 |
| IN2015DN01171A (https=) | 2015-06-26 |
| EP2872143A1 (en) | 2015-05-20 |
| KR20150031481A (ko) | 2015-03-24 |
| MX2015000618A (es) | 2015-04-10 |
| US9284309B2 (en) | 2016-03-15 |
| EP2872143A4 (en) | 2015-12-02 |
| WO2014014937A1 (en) | 2014-01-23 |
| CN104703604A (zh) | 2015-06-10 |
| AU2013290361A1 (en) | 2015-02-05 |
| HK1210598A1 (en) | 2016-04-29 |
| CA2877983A1 (en) | 2014-01-23 |
| US20150183776A1 (en) | 2015-07-02 |
| IL236712A0 (en) | 2015-02-26 |
| BR112015001096A2 (pt) | 2017-06-27 |
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