ES2658413T3 - Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina - Google Patents
Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina Download PDFInfo
- Publication number
- ES2658413T3 ES2658413T3 ES13779603.3T ES13779603T ES2658413T3 ES 2658413 T3 ES2658413 T3 ES 2658413T3 ES 13779603 T ES13779603 T ES 13779603T ES 2658413 T3 ES2658413 T3 ES 2658413T3
- Authority
- ES
- Spain
- Prior art keywords
- lysine
- disulfanodiylbis
- aminobutane
- sulfonic acid
- crystalline phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title abstract description 6
- 235000019766 L-Lysine Nutrition 0.000 title abstract description 3
- 239000004472 Lysine Substances 0.000 title abstract description 3
- HZHMBNYJWQUCHI-UHFFFAOYSA-N 3-aminobutane-1-sulfonic acid Chemical compound CC(N)CCS(O)(=O)=O HZHMBNYJWQUCHI-UHFFFAOYSA-N 0.000 title abstract 2
- 201000007694 Athabaskan brainstem dysgenesis syndrome Diseases 0.000 abstract description 3
- 208000020006 human HOXA1 syndromes Diseases 0.000 abstract description 3
- HZRUTVAFDWTKGD-JEDNCBNOSA-N (2s)-2,6-diaminohexanoic acid;hydrate Chemical compound O.NCCCC[C@H](N)C(O)=O HZRUTVAFDWTKGD-JEDNCBNOSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306307.5A EP2722327A1 (en) | 2012-10-22 | 2012-10-22 | Crystalline phase of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) with L-lysine |
| EP12306307 | 2012-10-22 | ||
| PCT/EP2013/072028 WO2014064077A1 (en) | 2012-10-22 | 2013-10-22 | Crystalline phase of (3s.3s') 4,4'-disulfanediylbis(3-aminobutane 1 -sulfonic acid) with l-lysine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2658413T3 true ES2658413T3 (es) | 2018-03-09 |
Family
ID=47278723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13779603.3T Active ES2658413T3 (es) | 2012-10-22 | 2013-10-22 | Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9278921B2 (enExample) |
| EP (2) | EP2722327A1 (enExample) |
| JP (1) | JP6317358B2 (enExample) |
| KR (1) | KR102103407B1 (enExample) |
| CN (1) | CN104768927B (enExample) |
| AR (1) | AR093070A1 (enExample) |
| AU (1) | AU2013336738B2 (enExample) |
| BR (1) | BR112015008931B1 (enExample) |
| CA (1) | CA2884914C (enExample) |
| CY (1) | CY1119913T1 (enExample) |
| DK (1) | DK2909169T3 (enExample) |
| EA (1) | EA024460B1 (enExample) |
| ES (1) | ES2658413T3 (enExample) |
| HR (1) | HRP20180189T1 (enExample) |
| HU (1) | HUE036037T2 (enExample) |
| IL (1) | IL237733B (enExample) |
| IN (1) | IN2015DN02807A (enExample) |
| LT (1) | LT2909169T (enExample) |
| ME (1) | ME02955B (enExample) |
| MX (1) | MX353693B (enExample) |
| NO (1) | NO2909169T3 (enExample) |
| NZ (1) | NZ706070A (enExample) |
| PL (1) | PL2909169T3 (enExample) |
| PT (1) | PT2909169T (enExample) |
| RS (1) | RS56896B1 (enExample) |
| SI (1) | SI2909169T1 (enExample) |
| SM (1) | SMT201800086T1 (enExample) |
| TW (1) | TWI643842B (enExample) |
| WO (1) | WO2014064077A1 (enExample) |
| ZA (1) | ZA201503574B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103951562B (zh) * | 2014-05-09 | 2016-04-20 | 四川九章生物化工科技发展有限公司 | 一种绿原酸晶型及其制备方法 |
| WO2022225712A1 (en) * | 2021-04-22 | 2022-10-27 | Teva Pharmaceuticals International Gmbh | Solid state forms of firibastat and processes for preparation thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003271811A1 (en) * | 2002-07-16 | 2004-02-02 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel derivatives of 4,4'-dithiobis-(3-aminobutane-1-sulphonates) and compositions containing same |
| FR2858617A1 (fr) * | 2003-08-06 | 2005-02-11 | Inst Nat Sante Rech Med | Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant |
| TWI370818B (en) * | 2006-04-05 | 2012-08-21 | Astellas Pharma Inc | Cocrystal of c-glycoside derivative and l-proline |
| EP2439192A1 (en) | 2010-10-07 | 2012-04-11 | Quantum Genomics | Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) |
| WO2012138907A2 (en) * | 2011-04-05 | 2012-10-11 | Translational Genomics Research Institute | Solid forms of curcumin |
-
2012
- 2012-10-22 EP EP12306307.5A patent/EP2722327A1/en not_active Withdrawn
-
2013
- 2013-10-18 AR ARP130103795A patent/AR093070A1/es unknown
- 2013-10-22 CA CA2884914A patent/CA2884914C/en active Active
- 2013-10-22 IN IN2807DEN2015 patent/IN2015DN02807A/en unknown
- 2013-10-22 EP EP13779603.3A patent/EP2909169B1/en active Active
- 2013-10-22 NZ NZ706070A patent/NZ706070A/en not_active IP Right Cessation
- 2013-10-22 KR KR1020157013661A patent/KR102103407B1/ko active Active
- 2013-10-22 MX MX2015005059A patent/MX353693B/es active IP Right Grant
- 2013-10-22 SI SI201330952T patent/SI2909169T1/en unknown
- 2013-10-22 PL PL13779603T patent/PL2909169T3/pl unknown
- 2013-10-22 HR HRP20180189TT patent/HRP20180189T1/hr unknown
- 2013-10-22 TW TW102138122A patent/TWI643842B/zh not_active IP Right Cessation
- 2013-10-22 ME MEP-2018-29A patent/ME02955B/me unknown
- 2013-10-22 PT PT137796033T patent/PT2909169T/pt unknown
- 2013-10-22 LT LTEP13779603.3T patent/LT2909169T/lt unknown
- 2013-10-22 EA EA201500438A patent/EA024460B1/ru unknown
- 2013-10-22 US US14/437,343 patent/US9278921B2/en not_active Expired - Fee Related
- 2013-10-22 RS RS20180133A patent/RS56896B1/sr unknown
- 2013-10-22 SM SM20180086T patent/SMT201800086T1/it unknown
- 2013-10-22 BR BR112015008931-3A patent/BR112015008931B1/pt not_active IP Right Cessation
- 2013-10-22 HU HUE13779603A patent/HUE036037T2/hu unknown
- 2013-10-22 DK DK13779603.3T patent/DK2909169T3/en active
- 2013-10-22 JP JP2015537299A patent/JP6317358B2/ja not_active Expired - Fee Related
- 2013-10-22 WO PCT/EP2013/072028 patent/WO2014064077A1/en not_active Ceased
- 2013-10-22 CN CN201380052793.5A patent/CN104768927B/zh not_active Expired - Fee Related
- 2013-10-22 NO NO13779603A patent/NO2909169T3/no unknown
- 2013-10-22 AU AU2013336738A patent/AU2013336738B2/en not_active Ceased
- 2013-10-22 ES ES13779603.3T patent/ES2658413T3/es active Active
-
2015
- 2015-03-12 IL IL237733A patent/IL237733B/en active IP Right Grant
- 2015-05-21 ZA ZA2015/03574A patent/ZA201503574B/en unknown
-
2016
- 2016-02-01 US US15/012,625 patent/US9487477B2/en not_active Expired - Fee Related
-
2018
- 2018-02-14 CY CY20181100179T patent/CY1119913T1/el unknown
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