ES2658413T3 - Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina - Google Patents

Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina Download PDF

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Publication number
ES2658413T3
ES2658413T3 ES13779603.3T ES13779603T ES2658413T3 ES 2658413 T3 ES2658413 T3 ES 2658413T3 ES 13779603 T ES13779603 T ES 13779603T ES 2658413 T3 ES2658413 T3 ES 2658413T3
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Prior art keywords
lysine
disulfanodiylbis
aminobutane
sulfonic acid
crystalline phase
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ES13779603.3T
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Fabrice Balavoine
Jean-Marie Schneider
Gérard Coquerel
Nicolas Couvrat
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Quantum Genomics SA
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Quantum Genomics SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Crystallography & Structural Chemistry (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una forma cristalina de (3S,3S') 4,4'-disulfanodiilbis (ácido 3-aminobutano 1-sulfónico) con L-lisina ABSD.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
a-Patrón de difracción de rayos X
La figura 2 presenta el patrón de XRPD de <ABSD. (L-lisina)2> obtenido en la solución (a) y por HEM (b) según el ejemplo 1, en comparación con el patrón de ABSD trihidrato (c) y el patrón de monohidrato de L-lisina (d). Una comparación visual de estos patrones muestra claramente que tanto en solución como a través de HEM se aisló una nueva fase. La siguiente tabla 2 describe la lista de los picos XPRD correspondientes al espectro de la figura 2a.
Tabla 2
Ángulo (2-Theta) °
valor d (Angstrom) Intensidad (Cuenta) Intensidad (%)
8,80
10,04 1259 100
11,72
7,54 1165 92,6
14,66
6,036 928 73,7
16,92
5,236 299 23,7
17,24
5,139 197 15,7
17,64
5,024 361 28,7
18,27
4,850 376 29,8
18,84
4,706 330 26,2
19,24
4,608 1037 82,4
19,76
4,489 802 63,7
20,39
4,351 546 43,4
21,04
4,218 378 30
23,52
3,779 210 16,7
24,28
3,662 262 20,8
24,36
3,650 279 22,2
24,88
3,575 352 28
25,04
3,553 314 24,9
25,24
3,525 377 29,9
25,52
3,487 217 17,2
26,53
3,357 794 63,1
27,64
3,224 284 22,6
28,76
3,102 205 16,3
28,88
3,089 239 19
7
imagen6
imagen7

Claims (1)

  1. imagen1
    imagen2
ES13779603.3T 2012-10-22 2013-10-22 Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina Active ES2658413T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306307 2012-10-22
EP12306307.5A EP2722327A1 (en) 2012-10-22 2012-10-22 Crystalline phase of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) with L-lysine
PCT/EP2013/072028 WO2014064077A1 (en) 2012-10-22 2013-10-22 Crystalline phase of (3s.3s') 4,4'-disulfanediylbis(3-aminobutane 1 -sulfonic acid) with l-lysine

Publications (1)

Publication Number Publication Date
ES2658413T3 true ES2658413T3 (es) 2018-03-09

Family

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ES13779603.3T Active ES2658413T3 (es) 2012-10-22 2013-10-22 Fase cristalina de (3S,3S') 4,4'-disulfanodiilbis(ácido 3-aminobutano 1-sulfónico) con L-lisina

Country Status (30)

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US (2) US9278921B2 (es)
EP (2) EP2722327A1 (es)
JP (1) JP6317358B2 (es)
KR (1) KR102103407B1 (es)
CN (1) CN104768927B (es)
AR (1) AR093070A1 (es)
AU (1) AU2013336738B2 (es)
BR (1) BR112015008931B1 (es)
CA (1) CA2884914C (es)
CY (1) CY1119913T1 (es)
DK (1) DK2909169T3 (es)
EA (1) EA024460B1 (es)
ES (1) ES2658413T3 (es)
HK (1) HK1212321A1 (es)
HR (1) HRP20180189T1 (es)
HU (1) HUE036037T2 (es)
IL (1) IL237733B (es)
IN (1) IN2015DN02807A (es)
LT (1) LT2909169T (es)
ME (1) ME02955B (es)
MX (1) MX353693B (es)
NO (1) NO2909169T3 (es)
NZ (1) NZ706070A (es)
PL (1) PL2909169T3 (es)
PT (1) PT2909169T (es)
RS (1) RS56896B1 (es)
SI (1) SI2909169T1 (es)
TW (1) TWI643842B (es)
WO (1) WO2014064077A1 (es)
ZA (1) ZA201503574B (es)

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Publication number Priority date Publication date Assignee Title
CN103951562B (zh) * 2014-05-09 2016-04-20 四川九章生物化工科技发展有限公司 一种绿原酸晶型及其制备方法
WO2022225712A1 (en) * 2021-04-22 2022-10-27 Teva Pharmaceuticals International Gmbh Solid state forms of firibastat and processes for preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2309336T3 (es) 2002-07-16 2008-12-16 Institut National De La Sante Et De La Recherche Medicale (Inserm) Derivados de 4,4-ditiobis-(3-aminobutano-1-sulfanatos) nuevos y composiciones que los contienen.
FR2858617A1 (fr) * 2003-08-06 2005-02-11 Inst Nat Sante Rech Med Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant
TWI370818B (en) * 2006-04-05 2012-08-21 Astellas Pharma Inc Cocrystal of c-glycoside derivative and l-proline
EP2439192A1 (en) 2010-10-07 2012-04-11 Quantum Genomics Method for the preparation of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid)
US9447050B2 (en) * 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin

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US9278921B2 (en) 2016-03-08
BR112015008931A2 (pt) 2017-07-04
US9487477B2 (en) 2016-11-08
PT2909169T (pt) 2018-02-26
MX353693B (es) 2018-01-24
EA024460B1 (ru) 2016-09-30
CN104768927B (zh) 2017-06-09
US20160221940A1 (en) 2016-08-04
RS56896B1 (sr) 2018-04-30
IN2015DN02807A (es) 2015-09-11
KR102103407B1 (ko) 2020-04-22
EP2909169B1 (en) 2018-01-03
WO2014064077A1 (en) 2014-05-01
US20150284325A1 (en) 2015-10-08
EP2909169A1 (en) 2015-08-26
JP6317358B2 (ja) 2018-04-25
CY1119913T1 (el) 2018-06-27
NZ706070A (en) 2018-11-30
AR093070A1 (es) 2015-05-13
ME02955B (me) 2018-07-20
JP2015536316A (ja) 2015-12-21
AU2013336738A1 (en) 2015-04-09
IL237733B (en) 2019-03-31
CA2884914C (en) 2021-01-05
HRP20180189T1 (hr) 2018-04-20
BR112015008931B1 (pt) 2021-05-18
DK2909169T3 (en) 2018-02-26
LT2909169T (lt) 2018-04-25
SI2909169T1 (en) 2018-04-30
ZA201503574B (en) 2016-01-27
CN104768927A (zh) 2015-07-08
CA2884914A1 (en) 2014-05-01
MX2015005059A (es) 2015-11-23
PL2909169T3 (pl) 2018-07-31
AU2013336738B2 (en) 2017-05-18
HK1212321A1 (en) 2016-06-10
EP2722327A1 (en) 2014-04-23
TW201418202A (zh) 2014-05-16
KR20150072454A (ko) 2015-06-29
HUE036037T2 (hu) 2018-06-28
NO2909169T3 (es) 2018-06-02
EA201500438A1 (ru) 2015-09-30
TWI643842B (zh) 2018-12-11

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