ES2650244T3 - Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres endometriales y uterinos - Google Patents
Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres endometriales y uterinos Download PDFInfo
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- ES2650244T3 ES2650244T3 ES15175154.2T ES15175154T ES2650244T3 ES 2650244 T3 ES2650244 T3 ES 2650244T3 ES 15175154 T ES15175154 T ES 15175154T ES 2650244 T3 ES2650244 T3 ES 2650244T3
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- 239000013598 vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57442—Specifically defined cancers of the uterus and endometrial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pregnancy & Childbirth (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75613106P | 2006-01-04 | 2006-01-04 | |
| US756131P | 2006-01-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2650244T3 true ES2650244T3 (es) | 2018-01-17 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15175154.2T Active ES2650244T3 (es) | 2006-01-04 | 2007-01-04 | Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres endometriales y uterinos |
| ES15175155T Active ES2748397T3 (es) | 2006-01-04 | 2007-01-04 | Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres de ovario |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15175155T Active ES2748397T3 (es) | 2006-01-04 | 2007-01-04 | Uso de HE4 y otros marcadores bioquímicos para la evaluación de cánceres de ovario |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US20080020473A1 (enExample) |
| EP (6) | EP2982761B1 (enExample) |
| JP (3) | JP5164855B2 (enExample) |
| CN (3) | CN101460630B (enExample) |
| ES (2) | ES2650244T3 (enExample) |
| PL (1) | PL2982761T3 (enExample) |
| WO (2) | WO2007081768A2 (enExample) |
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| AU5731400A (en) * | 1999-06-09 | 2000-12-28 | Moltech Corporation | Methods of preparing electrochemical cells |
| US7270960B2 (en) | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| EP1877795A4 (en) * | 2005-05-02 | 2010-04-28 | Brigham & Womens Hospital | DIAGNOSTIC PROFILE MANUFACTURE OF SERUM ANTIBODIES |
| EP2982761B1 (en) * | 2006-01-04 | 2017-10-04 | Fujirebio America, Inc. | Use of he4 and other biochemical markers for assessment of endometrial and uterine cancers |
| BRPI0707249A2 (pt) * | 2006-01-27 | 2011-04-26 | Tripath Imaging Inc | métodos para identificar pacientes com maior probabilidade de terem cáncer de ovário e composições para os mesmo |
| WO2008049239A1 (en) | 2006-10-27 | 2008-05-02 | Mount Sinai Hospital | Endometrial biomarkers |
| CA2679696A1 (en) * | 2007-03-09 | 2008-09-18 | Tripath Imaging, Inc. | He4 monoclonal antibodies and methods for their use |
| JP5144742B2 (ja) * | 2007-03-29 | 2013-02-13 | フジレビオ ダイアグノスティックス インコーポレイテッド | 乳がんの評価のためのｈｅ４の使用 |
| CN101377502A (zh) * | 2007-08-31 | 2009-03-04 | 北京科美东雅生物技术有限公司 | 肿瘤相关抗原72-4化学发光免疫分析测定试剂盒及其制备方法 |
| WO2009099561A2 (en) * | 2008-01-31 | 2009-08-13 | The Brigham And Womens' Hospital, Inc. | Urinary ca125 peptides as biomarkers of ovarian cancer |
| WO2009145815A2 (en) * | 2008-04-01 | 2009-12-03 | The Brigham And Women's Hospital, Inc. | Biomarkers of ovarian cancer |
| WO2012027631A2 (en) * | 2010-08-26 | 2012-03-01 | University Of Washington Through Its Center For Commercialization | Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells |
| ES2834617T3 (es) | 2011-02-17 | 2021-06-18 | Fujirebio Diagnostics Inc | Composiciones y métodos de uso para la determinación de HE4a |
| CA2828119A1 (en) * | 2011-02-24 | 2012-08-30 | Vermillion, Inc. | Biomarker panels, diagnostic methods and test kits for ovarian cancer |
| CN102735840B (zh) * | 2011-04-13 | 2014-06-04 | 中国医学科学院肿瘤研究所 | 用于诊断或筛查卵巢癌的试剂 |
| EP2717901A4 (en) * | 2011-06-06 | 2015-01-21 | Women And Infants Hospital Of Rhode Island | HE4-BASED THERAPY FOR MALIGNINE DISEASES |
| DE102012205164B4 (de) | 2012-03-29 | 2021-09-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Projektionsdisplay und Verfahren zur Projektion virtueller Bilder |
| CN103575902B (zh) * | 2012-08-03 | 2015-07-29 | 河南生生医疗器械有限公司 | 一种时间分辨荧光法四项综合检测卵巢癌试剂盒及其应用 |
| CN102890083B (zh) * | 2012-09-28 | 2016-08-10 | 辽宁科骏生物有限公司 | 化学发光底物溶液和含其的试剂盒及应用其的检测方法 |
| CN104655858B (zh) * | 2015-03-12 | 2016-02-10 | 德迈基生物技术（北京）有限公司 | 定量检测人附睾分泌蛋白-4的荧光免疫层析试剂盒及其制备方法 |
| EP3273974A4 (en) | 2015-03-26 | 2018-11-07 | Women and Infants Hospital of Rhode Island Inc. | Therapy for malignant disease |
| RU2585959C1 (ru) * | 2015-06-22 | 2016-06-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ дифференциальной диагностики асцитно-инфильтративной формы рака яичников и абдоминального туберкулёза |
| US10267802B2 (en) | 2015-09-23 | 2019-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of prognosis and diagnosis of ovarian cancer |
| RU2624508C1 (ru) * | 2016-06-29 | 2017-07-04 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ прогнозирования длительности ремиссии у больных раком вульвы |
| EP3482205A1 (en) | 2016-07-08 | 2019-05-15 | H. Hoffnabb-La Roche Ag | Use of human epididymis protein 4 (he4) for assessing responsiveness of muc 16-positive cancer treatment |
| US20230159586A1 (en) | 2020-04-21 | 2023-05-25 | University Of Rochester | Inhibitors of human epididymus protein 4 |
| CN111781364B (zh) * | 2020-08-25 | 2023-07-21 | 北京信诺卫康科技有限公司 | Wnt7a和HE4联合用作早期卵巢癌生物标志物以及试剂盒 |
| WO2022140116A1 (en) | 2020-12-21 | 2022-06-30 | Freenome Holdings, Inc. | Markers for the early detection of colon cell proliferative disorders |
| WO2023195629A1 (ko) * | 2022-04-08 | 2023-10-12 | 아주대학교산학협력단 | He4 검출용 펩타이드 및 그 용도 |
| WO2023195628A1 (ko) * | 2022-04-08 | 2023-10-12 | 아주대학교산학협력단 | Ca125 검출용 펩타이드 및 그 용도 |
| CN120254284B (zh) * | 2025-06-03 | 2025-08-22 | 杭州广科安德生物科技有限公司 | 一种用于预测子宫内膜癌复发或转移风险的生物标志物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| CA1289880C (en) * | 1985-12-06 | 1991-10-01 | Jeffrey L. Winkelhake | Anti-human ovarian cancer immunotoxins and methods of use thereof |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPH02500329A (ja) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US6998106B1 (en) * | 1998-12-01 | 2006-02-14 | Duke University | Radioconjugation of internalizing antibodies |
| CA2369433A1 (en) | 1999-02-26 | 2000-08-31 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| US6770445B1 (en) * | 1999-02-26 | 2004-08-03 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| US20020182619A1 (en) * | 2000-11-08 | 2002-12-05 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
| US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| DK1540010T3 (da) * | 2002-08-06 | 2010-07-26 | Univ Johns Hopkins | Anvendelse af biomarkører til påvisning af ovariecancer |
| AU2003269968A1 (en) * | 2002-08-16 | 2004-03-11 | Clinical Microarrays, Inc. | Substrates for isolating, reacting and microscopically analyzing materials |
| AU2003290773A1 (en) * | 2003-02-05 | 2004-09-06 | Ciphergen Biosystems, Inc. | Non-invasive assessment of intra-amniotic environment |
| EP1633784B1 (en) * | 2003-05-09 | 2011-07-13 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| CN1266475C (zh) * | 2003-06-05 | 2006-07-26 | 马旭 | 一种用于诊断早期卵巢癌的四粘蛋白酶联免疫检测试剂盒 |
| EP1723428A2 (en) * | 2004-02-19 | 2006-11-22 | Yale University Corporation | Identification of cancer protein biomarkers using proteomic techniques |
| WO2005098446A2 (en) * | 2004-03-31 | 2005-10-20 | The Johns Hopkins University | Biomarkers for ovarian cancer |
| US8486648B2 (en) * | 2005-02-16 | 2013-07-16 | Dana-Farber Cancer Institute, Inc. | Methods of detecting ovarian cancer |
| US20070172902A1 (en) * | 2005-06-22 | 2007-07-26 | The Johns Hopkins University, a non-profit organization | Biomarker for ovarian cancer |
| EP1910821B1 (en) * | 2005-06-24 | 2013-02-20 | Ciphergen Biosystems, Inc. | Biomarkers for ovarian cancer |
| EP2982761B1 (en) * | 2006-01-04 | 2017-10-04 | Fujirebio America, Inc. | Use of he4 and other biochemical markers for assessment of endometrial and uterine cancers |
-
2007
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- 2007-01-04 JP JP2008549562A patent/JP5164855B2/ja active Active
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- 2007-01-04 US US11/650,573 patent/US20080020473A1/en not_active Abandoned
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- 2007-01-04 EP EP07717677A patent/EP1846768A4/en not_active Withdrawn
- 2007-01-04 CN CN200780007130.6A patent/CN101460630B/zh active Active
- 2007-01-04 PL PL15175154T patent/PL2982761T3/pl unknown
- 2007-01-04 JP JP2008549563A patent/JP5221381B2/ja active Active
- 2007-01-04 WO PCT/US2007/000216 patent/WO2007081768A2/en not_active Ceased
- 2007-01-04 ES ES15175155T patent/ES2748397T3/es active Active
- 2007-01-04 US US11/650,337 patent/US20070286865A1/en not_active Abandoned
- 2007-01-04 CN CN200780007052.XA patent/CN101473041B/zh active Active
- 2007-01-04 WO PCT/US2007/000215 patent/WO2007081767A2/en not_active Ceased
- 2007-01-04 CN CN201610512072.3A patent/CN106124765A/zh active Pending
- 2007-01-04 EP EP07717842A patent/EP1969136A4/en not_active Withdrawn
- 2007-01-04 EP EP11171015A patent/EP2420576A3/en not_active Withdrawn
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2012
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2018
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2020
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2023
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2024
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