ES264827A1 - Procedimiento para la fabricaciën de sulfamidas del grupo pirimidinico - Google Patents

Procedimiento para la fabricaciën de sulfamidas del grupo pirimidinico

Info

Publication number
ES264827A1
ES264827A1 ES0264827A ES264827A ES264827A1 ES 264827 A1 ES264827 A1 ES 264827A1 ES 0264827 A ES0264827 A ES 0264827A ES 264827 A ES264827 A ES 264827A ES 264827 A1 ES264827 A1 ES 264827A1
Authority
ES
Spain
Prior art keywords
sulphanilamido
pyrimidine
salts
manufacture
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0264827A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES264827A1 publication Critical patent/ES264827A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la fabricación de sulfamidas del grupo pirimidínico, el cual procedimiento comprende, o bien el condensar una pirimidina de la fórmula general (**formula**) en que el símbolo hal representa halógeno , y el símbolo R representa halógeno o alcoxi bajo, con una sal alcalina de sulfanilamida o un derivado N4-acilo de la misma, el reemplazar el substituyente 6-halo (si está presente en el producto de condensación) por alcoxi bajo y el disociar el grupo N4-acilo (si está presente en el producto de condensación), o bien el condensar una 4-amino-6-alcoxi bajo-pirimidina con un haluro de bencensulfonilo substituido en 4, en que el substituyente 4 es convertible al grupo amino, el convertir dicho substituyente 4 a un grupo amino y el convertir, si se desea, la 4-sulfanilamido-6-alcoxi bajo-pirimidina así obtenida en una sal farmacéuticamente aceptable.
ES0264827A 1960-02-12 1961-02-11 Procedimiento para la fabricaciën de sulfamidas del grupo pirimidinico Expired ES264827A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH155060 1960-02-12

Publications (1)

Publication Number Publication Date
ES264827A1 true ES264827A1 (es) 1961-08-01

Family

ID=4213021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0264827A Expired ES264827A1 (es) 1960-02-12 1961-02-11 Procedimiento para la fabricaciën de sulfamidas del grupo pirimidinico

Country Status (5)

Country Link
BE (1) BE600035A (es)
ES (1) ES264827A1 (es)
FR (1) FR916M (es)
GB (1) GB914455A (es)
NL (1) NL260980A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459742A (en) * 1965-06-01 1969-08-05 Hoffmann La Roche Sulfanilamide derivatives and processes

Also Published As

Publication number Publication date
GB914455A (en) 1963-01-02
BE600035A (es)
FR916M (es) 1961-11-06
NL260980A (es)

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