ES2628322T3 - Compuestos de tiol y su uso para la síntesis de oligonucleótidos modificados - Google Patents

Compuestos de tiol y su uso para la síntesis de oligonucleótidos modificados Download PDF

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Publication number
ES2628322T3
ES2628322T3 ES13713922.6T ES13713922T ES2628322T3 ES 2628322 T3 ES2628322 T3 ES 2628322T3 ES 13713922 T ES13713922 T ES 13713922T ES 2628322 T3 ES2628322 T3 ES 2628322T3
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Spain
Prior art keywords
compound
groups
chosen
group
oxygenated
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13713922.6T
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English (en)
Spanish (es)
Inventor
François MORVAN
Albert Meyer
Jean-Jacques Vasseur
Julie MAYEN
Carole Chaix
Carole FARRE
Chantal Fournier-Wirth
Jean-François CANTALOUBE
Myriam LEREAU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Etablissement Francais du Sang
Universite de Montpellier
Universite Claude Bernard Lyon 1
Original Assignee
Centre National de la Recherche Scientifique CNRS
Etablissement Francais du Sang
Universite de Montpellier
Universite Claude Bernard Lyon 1
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Publication of ES2628322T3 publication Critical patent/ES2628322T3/es
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F257/00Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
    • C08F257/02Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00 on to polymers of styrene or alkyl-substituted styrenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ES13713922.6T 2012-04-04 2013-04-04 Compuestos de tiol y su uso para la síntesis de oligonucleótidos modificados Active ES2628322T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1253121 2012-04-04
FR1253121A FR2989086B1 (fr) 2012-04-04 2012-04-04 Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies
PCT/EP2013/057122 WO2013150106A1 (fr) 2012-04-04 2013-04-04 Composés thiol et leur utilisation pour la synthèse d'oligonucléotides modifiés

Publications (1)

Publication Number Publication Date
ES2628322T3 true ES2628322T3 (es) 2017-08-02

Family

ID=48045562

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13713922.6T Active ES2628322T3 (es) 2012-04-04 2013-04-04 Compuestos de tiol y su uso para la síntesis de oligonucleótidos modificados

Country Status (7)

Country Link
US (2) US9896473B2 (enExample)
EP (1) EP2834253B1 (enExample)
JP (1) JP6152415B2 (enExample)
CA (1) CA2869429C (enExample)
ES (1) ES2628322T3 (enExample)
FR (1) FR2989086B1 (enExample)
WO (1) WO2013150106A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2909632B2 (ja) 1989-12-29 1999-06-23 基礎地盤コンサルタンツ株式会社 地下水採取器及びこれを用いた地下水水質測定法
FR2989089B1 (fr) 2012-04-04 2020-02-07 Etablissement Francais Du Sang Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques
JP7282379B2 (ja) * 2017-08-22 2023-05-29 国立大学法人東海国立大学機構 修飾ポリヌクレオチド
EP4305198A1 (en) 2021-03-09 2024-01-17 Etablissement Français du Sang Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination
CN113289587B (zh) * 2021-05-10 2023-11-28 苏州君盟生物医药科技有限公司 巯基修饰的磁性纳米微球及其制备方法、应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE922292A1 (en) * 1991-07-15 1993-01-27 Jolla Pharma Modified phosphorous intermediates for providing functional¹groups on the 5' end of oligonucleotides
DE10163836A1 (de) * 2001-12-22 2003-07-10 Friz Biochem Gmbh Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren
CA2650668A1 (en) * 2006-04-28 2007-11-08 Centre National De La Recherche Scientifique Method for the synthesis of triazole-containing oligonucleotide deratives
WO2009061941A2 (en) * 2007-11-06 2009-05-14 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof

Also Published As

Publication number Publication date
FR2989086A1 (fr) 2013-10-11
WO2013150106A1 (fr) 2013-10-10
CA2869429C (fr) 2022-11-01
FR2989086B1 (fr) 2017-03-24
EP2834253B1 (fr) 2017-03-29
US11078229B2 (en) 2021-08-03
JP2015515471A (ja) 2015-05-28
US9896473B2 (en) 2018-02-20
EP2834253A1 (fr) 2015-02-11
JP6152415B2 (ja) 2017-06-21
US20180265538A1 (en) 2018-09-20
CA2869429A1 (fr) 2013-10-10
US20150158964A1 (en) 2015-06-11

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