FR2989086B1 - Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies - Google Patents

Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies

Info

Publication number
FR2989086B1
FR2989086B1 FR1253121A FR1253121A FR2989086B1 FR 2989086 B1 FR2989086 B1 FR 2989086B1 FR 1253121 A FR1253121 A FR 1253121A FR 1253121 A FR1253121 A FR 1253121A FR 2989086 B1 FR2989086 B1 FR 2989086B1
Authority
FR
France
Prior art keywords
synthesis
modified oligonucleotides
thiol compounds
thiol
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1253121A
Other languages
English (en)
French (fr)
Other versions
FR2989086A1 (fr
Inventor
Francois Morvan
Albert Meyer
Jean-Jacques Vasseur
Julie Mayen
Carole Chaix
Carole Farre
Chantal Fournier-Wirth
Jean-Francois Cantaloube
Myriam Lereau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Etablissement Francais du Sang
Universite de Montpellier
Universite Claude Bernard Lyon 1
Original Assignee
Centre National de la Recherche Scientifique CNRS
Etablissement Francais du Sang
Universite de Montpellier
Universite Claude Bernard Lyon 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1253121A priority Critical patent/FR2989086B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Etablissement Francais du Sang, Universite de Montpellier, Universite Claude Bernard Lyon 1 filed Critical Centre National de la Recherche Scientifique CNRS
Priority to PCT/EP2013/057122 priority patent/WO2013150106A1/fr
Priority to US14/390,747 priority patent/US9896473B2/en
Priority to JP2015503881A priority patent/JP6152415B2/ja
Priority to EP13713922.6A priority patent/EP2834253B1/fr
Priority to CA2869429A priority patent/CA2869429C/fr
Priority to ES13713922.6T priority patent/ES2628322T3/es
Publication of FR2989086A1 publication Critical patent/FR2989086A1/fr
Application granted granted Critical
Publication of FR2989086B1 publication Critical patent/FR2989086B1/fr
Priority to US15/862,485 priority patent/US11078229B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F257/00—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
    • C08F257/02—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00 on to polymers of styrene or alkyl-substituted styrenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
FR1253121A 2012-04-04 2012-04-04 Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies Active FR2989086B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1253121A FR2989086B1 (fr) 2012-04-04 2012-04-04 Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies
US14/390,747 US9896473B2 (en) 2012-04-04 2013-04-04 Thiol compounds and the use thereof for the synthesis of modified oligonucleotides
JP2015503881A JP6152415B2 (ja) 2012-04-04 2013-04-04 チオール化合物および修飾オリゴヌクレオチド合成のためのこれらの使用
EP13713922.6A EP2834253B1 (fr) 2012-04-04 2013-04-04 Composés thiol et leur utilisation pour la synthèse d'oligonucléotides modifiés
PCT/EP2013/057122 WO2013150106A1 (fr) 2012-04-04 2013-04-04 Composés thiol et leur utilisation pour la synthèse d'oligonucléotides modifiés
CA2869429A CA2869429C (fr) 2012-04-04 2013-04-04 Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies
ES13713922.6T ES2628322T3 (es) 2012-04-04 2013-04-04 Compuestos de tiol y su uso para la síntesis de oligonucleótidos modificados
US15/862,485 US11078229B2 (en) 2012-04-04 2018-01-04 Thiol compounds and the use thereof for the synthesis of modified oligonucleotides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1253121A FR2989086B1 (fr) 2012-04-04 2012-04-04 Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies

Publications (2)

Publication Number Publication Date
FR2989086A1 FR2989086A1 (fr) 2013-10-11
FR2989086B1 true FR2989086B1 (fr) 2017-03-24

Family

ID=48045562

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1253121A Active FR2989086B1 (fr) 2012-04-04 2012-04-04 Composes thiol et leur utilisation pour la synthese d'oligonucleotides modifies

Country Status (7)

Country Link
US (2) US9896473B2 (enExample)
EP (1) EP2834253B1 (enExample)
JP (1) JP6152415B2 (enExample)
CA (1) CA2869429C (enExample)
ES (1) ES2628322T3 (enExample)
FR (1) FR2989086B1 (enExample)
WO (1) WO2013150106A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2909632B2 (ja) 1989-12-29 1999-06-23 基礎地盤コンサルタンツ株式会社 地下水採取器及びこれを用いた地下水水質測定法
FR2989089B1 (fr) 2012-04-04 2020-02-07 Etablissement Francais Du Sang Oligonucleotides modifies comprenant des fonctions thiol et leur utilisation pour la detection d'acides nucleiques
JP7282379B2 (ja) * 2017-08-22 2023-05-29 国立大学法人東海国立大学機構 修飾ポリヌクレオチド
EP4305198A1 (en) 2021-03-09 2024-01-17 Etablissement Français du Sang Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination
CN113289587B (zh) * 2021-05-10 2023-11-28 苏州君盟生物医药科技有限公司 巯基修饰的磁性纳米微球及其制备方法、应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE922292A1 (en) * 1991-07-15 1993-01-27 Jolla Pharma Modified phosphorous intermediates for providing functional¹groups on the 5' end of oligonucleotides
DE10163836A1 (de) * 2001-12-22 2003-07-10 Friz Biochem Gmbh Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren
CA2650668A1 (en) * 2006-04-28 2007-11-08 Centre National De La Recherche Scientifique Method for the synthesis of triazole-containing oligonucleotide deratives
WO2009061941A2 (en) * 2007-11-06 2009-05-14 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof

Also Published As

Publication number Publication date
FR2989086A1 (fr) 2013-10-11
WO2013150106A1 (fr) 2013-10-10
CA2869429C (fr) 2022-11-01
EP2834253B1 (fr) 2017-03-29
US11078229B2 (en) 2021-08-03
JP2015515471A (ja) 2015-05-28
US9896473B2 (en) 2018-02-20
EP2834253A1 (fr) 2015-02-11
JP6152415B2 (ja) 2017-06-21
US20180265538A1 (en) 2018-09-20
CA2869429A1 (fr) 2013-10-10
US20150158964A1 (en) 2015-06-11
ES2628322T3 (es) 2017-08-02

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