ES2627099T3 - Compuestos para el tratamiento de enfermedades relacionadas con la vía de mTOR - Google Patents

Compuestos para el tratamiento de enfermedades relacionadas con la vía de mTOR Download PDF

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ES2627099T3
ES2627099T3 ES13827913T ES13827913T ES2627099T3 ES 2627099 T3 ES2627099 T3 ES 2627099T3 ES 13827913 T ES13827913 T ES 13827913T ES 13827913 T ES13827913 T ES 13827913T ES 2627099 T3 ES2627099 T3 ES 2627099T3
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diseases related
diseases
alkyl
treatment
mtor
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Mohammad Hossein Pourgholami
David L. Morris
Roger Aston
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Pitney Pharmaceuticals Pty Ltd
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Pulmonology (AREA)
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Abstract

Un compuesto de la Fórmula (I): o una sal aceptable farmacéuticamente, o solvato de este, para usar en el tratamiento de una o más enfermedades relacionadas con la vía de mTOR, en donde la una, o más enfermedades relacionadas con la vía de mTOR se seleccionan de enfermedades neurodegenerativas, enfermedades relacionadas con la edad, enfermedades relacionadas con el rechazo de trasplante, enfermedades inflamatorias crónicas, enfermedades relacionadas con el almacenamiento de glucógeno, lupus sistémico, enfermedades relacionadas con la inflamación y la activación inmune, anemia, leucopenia, trombocitopenia, enfermedades relacionadas con el recubrimiento de endoprótesis, insuficiencia renal, obesidad, diabetes/resistencia a la insulina, enfermedades relacionadas con el hígado graso no alcohólico, riñón poliquístico y fibrosis y en donde, R1 es -CN; R2 y R3 y R5 cada uno se selecciona independientemente de H, alquilo, halógeno, -CF3 o -CN; R4 y R6 cada uno se selecciona independientemente de H, alquilo, halógeno, alcoxi, -CF3, -OCF3, -SO2CF3, - SOCF3 o -SCF3; X es un heteroátomo, N(alquil) o NH; y n es de 1 a 20.
ES13827913T 2012-08-06 2013-08-05 Compuestos para el tratamiento de enfermedades relacionadas con la vía de mTOR Active ES2627099T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2012903365A AU2012903365A0 (en) 2012-08-06 Compounds for the treatment of mTOR pathway related diseases
PCT/AU2013/000859 WO2014022879A1 (en) 2012-08-06 2013-08-05 Compounds for the treatment of mtor pathway related diseases

Publications (1)

Publication Number Publication Date
ES2627099T3 true ES2627099T3 (es) 2017-07-26

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Family Applications (2)

Application Number Title Priority Date Filing Date
ES13827913T Active ES2627099T3 (es) 2012-08-06 2013-08-05 Compuestos para el tratamiento de enfermedades relacionadas con la vía de mTOR
ES17162895T Active ES2757598T3 (es) 2012-08-06 2013-08-05 Compuestos para el tratamiento de las enfermedades relacionadas con la vía mTOR

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ES17162895T Active ES2757598T3 (es) 2012-08-06 2013-08-05 Compuestos para el tratamiento de las enfermedades relacionadas con la vía mTOR

Country Status (13)

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US (2) US9790176B2 (es)
EP (2) EP3202397B1 (es)
JP (2) JP6441219B2 (es)
KR (1) KR102124392B1 (es)
CN (2) CN105496999A (es)
AU (2) AU2013302209B2 (es)
CA (1) CA2881325C (es)
ES (2) ES2627099T3 (es)
HK (1) HK1205502A1 (es)
NZ (2) NZ631523A (es)
PL (1) PL2880014T3 (es)
WO (1) WO2014022879A1 (es)
ZA (1) ZA201501390B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2627099T3 (es) 2012-08-06 2017-07-26 Pitney Pharmaceuticals Pty Limited Compuestos para el tratamiento de enfermedades relacionadas con la vía de mTOR
AU2014344789B2 (en) * 2013-11-01 2019-10-03 Pitney Pharmaceuticals Pty Limited Pharmaceutical combinations for the treatment of cancer
US10258639B2 (en) * 2014-05-06 2019-04-16 Research Development Foundation Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy
RS64114B1 (sr) 2015-10-23 2023-04-28 Navitor Pharm Inc Modulatori interakcije sestrin-gator2 i nјihova upotreba
WO2018200625A1 (en) 2017-04-26 2018-11-01 Navitor Pharmaceuticals, Inc. Modulators of sestrin-gator2 interaction and uses thereof
JP2022500384A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
WO2020086816A1 (en) * 2018-10-24 2020-04-30 Navitor Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
WO2021087432A1 (en) * 2019-11-01 2021-05-06 Navitor Pharmaceuticals, Inc. Methods of treatment using an mtorc1 modulator
KR102371269B1 (ko) * 2020-03-11 2022-03-07 연세대학교 산학협력단 VEGFR-3 발현 조절을 통한 mTOR 관련 질환의 예방 또는 치료 방법
CN113577086B (zh) * 2020-04-30 2023-05-02 沈阳福洋医药科技有限公司 异戊酰螺旋霉素类化合物或其组合物在制备治疗免疫失调的药物中的应用
EP4149454A1 (en) * 2020-05-11 2023-03-22 Pitney Pharmaceuticals Pty Limited Use of aminoacetonitrile compounds for the treatment of infection and disease
CN115304600B (zh) * 2022-09-29 2023-01-13 北京鑫开元医药科技有限公司 mTOR抑制剂、制备方法及用途

Family Cites Families (12)

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HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6239077B1 (en) * 1998-05-01 2001-05-29 Nihon Nohyaku Co., Ltd. Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof
AT408615B (de) 1998-09-15 2002-01-25 Immuno Ag Neue influenzavirus-impfstoffzusammensetzung
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
TWI292712B (en) * 2000-12-20 2008-01-21 Novartis Ag Aminoacetonitrile compounds for use in the control of endoparasites
DK1812385T3 (da) * 2004-11-09 2012-10-15 Novartis Ag Fremgangsmåde til fremstilling af enantiomere af amidoacetonitrilforbindelser ud fra deres racemater
US20090286838A1 (en) * 2004-12-06 2009-11-19 Newsouth Innovations Pty Limited Treatment for cancer
AR054822A1 (es) 2005-07-07 2007-07-18 Sanofi Pasteur Emulsion inmuno adyuvante
CN105534969B (zh) * 2012-03-23 2019-04-05 皮特尼制药股份有限公司 用于癌症治疗的激酶抑制剂
ES2627099T3 (es) 2012-08-06 2017-07-26 Pitney Pharmaceuticals Pty Limited Compuestos para el tratamiento de enfermedades relacionadas con la vía de mTOR
AU2014344789B2 (en) * 2013-11-01 2019-10-03 Pitney Pharmaceuticals Pty Limited Pharmaceutical combinations for the treatment of cancer

Also Published As

Publication number Publication date
US20150166477A1 (en) 2015-06-18
US9790176B2 (en) 2017-10-17
US20170369435A1 (en) 2017-12-28
CA2881325C (en) 2020-09-29
AU2013302209B2 (en) 2016-09-29
CN104837812B (zh) 2017-09-26
PL2880014T3 (pl) 2017-10-31
CA2881325A1 (en) 2014-02-13
WO2014022879A1 (en) 2014-02-13
CN105496999A (zh) 2016-04-20
JP6441219B2 (ja) 2018-12-19
JP2018062526A (ja) 2018-04-19
ES2757598T3 (es) 2020-04-29
EP2880014A1 (en) 2015-06-10
EP3202397B1 (en) 2019-09-25
JP6509386B2 (ja) 2019-05-08
AU2016234924B2 (en) 2017-04-13
KR20150081422A (ko) 2015-07-14
JP2015524446A (ja) 2015-08-24
NZ631523A (en) 2017-03-31
EP3202397A1 (en) 2017-08-09
CN104837812A (zh) 2015-08-12
AU2013302209A1 (en) 2015-02-19
EP2880014A4 (en) 2015-12-30
HK1205502A1 (en) 2015-12-18
NZ729555A (en) 2017-08-25
US10053422B2 (en) 2018-08-21
AU2016234924A1 (en) 2016-10-20
KR102124392B1 (ko) 2020-06-19
EP2880014B1 (en) 2017-05-17
ZA201501390B (en) 2017-09-27

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