ES2624448T3 - Implantes poliméricos de agonistas alfa-2 adrenérgicos biodegradables - Google Patents

Implantes poliméricos de agonistas alfa-2 adrenérgicos biodegradables Download PDF

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Publication number
ES2624448T3
ES2624448T3 ES09799446.1T ES09799446T ES2624448T3 ES 2624448 T3 ES2624448 T3 ES 2624448T3 ES 09799446 T ES09799446 T ES 09799446T ES 2624448 T3 ES2624448 T3 ES 2624448T3
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ES
Spain
Prior art keywords
implant
polymer
release
implants
eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09799446.1T
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English (en)
Spanish (es)
Inventor
Lon T. Spada
Alazar N. Ghebremeskel
Michael R. Robinson
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Allergan Inc
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Allergan Inc
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Publication of ES2624448T3 publication Critical patent/ES2624448T3/es
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
ES09799446.1T 2008-11-17 2009-11-06 Implantes poliméricos de agonistas alfa-2 adrenérgicos biodegradables Active ES2624448T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US272548 2002-10-16
US12/272,548 US9095506B2 (en) 2008-11-17 2008-11-17 Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
PCT/US2009/063490 WO2010056598A2 (en) 2008-11-17 2009-11-06 Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
ES2624448T3 true ES2624448T3 (es) 2017-07-14

Family

ID=41698087

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09799446.1T Active ES2624448T3 (es) 2008-11-17 2009-11-06 Implantes poliméricos de agonistas alfa-2 adrenérgicos biodegradables

Country Status (7)

Country Link
US (7) US9095506B2 (cg-RX-API-DMAC7.html)
EP (1) EP2355795B1 (cg-RX-API-DMAC7.html)
JP (2) JP5580832B2 (cg-RX-API-DMAC7.html)
AU (3) AU2009314266A1 (cg-RX-API-DMAC7.html)
CA (1) CA2743837C (cg-RX-API-DMAC7.html)
ES (1) ES2624448T3 (cg-RX-API-DMAC7.html)
WO (1) WO2010056598A2 (cg-RX-API-DMAC7.html)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8529927B2 (en) * 2004-04-30 2013-09-10 Allergan, Inc. Alpha-2 agonist polymeric drug delivery systems
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US20100104654A1 (en) 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2762536C (en) 2009-05-18 2019-05-21 Dose Medical Corporation Drug eluting ocular implant
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
CA2764063C (en) 2009-06-03 2019-05-14 Forsight Labs, Llc Anterior segment drug delivery
JP5982287B2 (ja) 2009-11-09 2016-08-31 アラーガン、インコーポレイテッドAllergan,Incorporated 発毛を刺激する組成物および方法
ES2561083T3 (es) 2010-01-22 2016-02-24 Allergan, Inc. Implantes intracamerales de agentes terapéuticos de liberación sostenida
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US20120213840A1 (en) * 2011-02-18 2012-08-23 Valeant International (Barbados) Srl Ocular strips
EP2701682A1 (en) 2011-04-29 2014-03-05 Allergan, Inc. Solvent cast film sustained release latanoprost implant
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
ES2912370T3 (es) 2011-09-14 2022-05-25 Forsight Vision5 Inc Aparato para inserción ocular
US20180126033A9 (en) 2012-03-14 2018-05-10 MAM Holdings of West Florida, L.L.C. Collagen compositions and uses for biomaterial implants
CA2867203C (en) * 2012-03-16 2016-09-20 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
JP5883539B2 (ja) 2012-03-16 2016-03-15 ザ・ジョンズ・ホプキンス・ユニバーシティー Hif−1阻害剤の送達のための放出制御製剤
JP6298068B2 (ja) 2012-10-26 2018-03-20 フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. 眼に対する薬物徐放用眼科システム
HK1218850A1 (zh) * 2013-02-15 2017-03-17 Allergan, Inc. 持续药物递送植入物
KR20150141972A (ko) * 2013-04-12 2015-12-21 알레간 인코포레이티드 지방 감소를 위한 비마토프로스트, 비마토프로스트 유사체, 프로스타미드 및 프로스타글란딘의 서방출
SG11201603383VA (en) 2013-10-31 2016-05-30 Allergan Inc Prostamide-containing intraocular implants and methods of use thereof
MX2016007345A (es) * 2013-12-06 2016-12-09 Envisia Therapeutics Inc Implante intracameral para el tratamiento de una condicion ocular.
EP3145549A4 (en) * 2014-05-23 2018-02-14 Ocular Technologies Sàrl Topical formulations and uses thereof
EP3677229A1 (en) 2014-05-29 2020-07-08 Glaukos Corporation Implants with controlled drug delivery features
EP3179982B1 (en) * 2014-07-28 2023-07-19 Sun Pharma Advanced Research Company Ltd Method of increasing bioavailability and/or prolonging ophthalmic action of a drug
MX2017001863A (es) 2014-08-13 2017-07-17 Univ Johns Hopkins Nanoparticulas cargadas con glucocorticoides para prevencion de rechazo de aloinjerto corneal y neovascularizacion.
SG10201903210WA (en) 2014-12-15 2019-05-30 Univ Johns Hopkins Sunitinib Formulations and Methods for Use Thereof in Treatment of Ocular Disorders
WO2016118506A1 (en) 2015-01-20 2016-07-28 The Johns Hopkins University Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure
ES2830177T3 (es) 2015-03-06 2021-06-03 Aerie Pharmaceuticals Inc Aplicadores de implantes
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
WO2017015604A1 (en) 2015-07-23 2017-01-26 Envisia Therapeutics, Inc. Intravitreal drug delivery systems for the treatment of ocular conditions
EP3943072A1 (en) * 2015-07-27 2022-01-26 Sun Pharma Advanced Research Company Ltd Drug loaded nanoresin particles
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
HK1257499A1 (zh) 2015-11-12 2019-10-25 Graybug Vision, Inc. 用於治疗的聚集性微粒
US9579350B1 (en) 2016-02-25 2017-02-28 MAM Holdings of West Florida, L.L.C. Human amniotic fluid preparation having long-term stability
US20190022016A1 (en) 2016-03-02 2019-01-24 The Johns Hopkins University Compositions for sustained release of anti-glaucoma agents to control intraocular pressure
CA3022830A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
WO2018045386A1 (en) 2016-09-02 2018-03-08 Envisia Therapeutics, Inc. Implant applicators
AU2018240462C1 (en) 2017-03-23 2022-12-08 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス, インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
EP3737433A1 (en) 2018-01-08 2020-11-18 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
EP3793536A1 (en) 2018-05-12 2021-03-24 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
JP2021529747A (ja) * 2018-06-25 2021-11-04 タイタン ファーマシューティカルズ インコーポレイテッド 親油性又は両親媒性医薬物質の放出のためのインプラント
WO2020047013A1 (en) 2018-08-28 2020-03-05 Foundry Therapeutics, Inc. Polymer implants
JP7570342B2 (ja) 2019-03-05 2024-10-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼の疾患又は障害を治療するための医薬組成物
BR112023001073A2 (pt) 2020-07-21 2023-03-07 Allergan Inc Implante intraocular com alto carregamento de prostamida
AU2023355823A1 (en) 2022-10-05 2025-04-17 Mireca Medicines Gmbh MICROPARTICLE AND IMPLANT FORMULATIONS FOR cGMP ANALOG THERAPY
WO2025179071A1 (en) * 2024-02-20 2025-08-28 Bausch + Lomb Ireland Limited Sustained-release drug delivery compositions for treating ocular diseases

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2054102A (en) 1936-09-15 Voting machine
NL64744C (cg-RX-API-DMAC7.html) 1940-03-09
US2401708A (en) 1943-01-19 1946-06-04 Eastman Kodak Co Range finder
US2401408A (en) 1944-05-03 1946-06-04 Harold S Bixby Lock for fluorescent lamps
US2743837A (en) 1953-06-01 1956-05-01 Leon J Cook Lead sleeve expanding device
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
JPS58126435U (ja) * 1982-02-19 1983-08-27 オリンパス光学工業株式会社 Ttlオ−トストロボ用絞り制御回路
US4521210A (en) * 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) * 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US5264188A (en) * 1991-01-22 1993-11-23 Phillips Petroleum Company Multi-stage hydrotreating process and apparatus
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6369116B1 (en) * 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US6194415B1 (en) * 1995-06-28 2001-02-27 Allergan Sales, Inc. Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
US5856329A (en) * 1995-06-28 1999-01-05 Allergan Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury
US6066675A (en) * 1996-09-13 2000-05-23 The Regents Of The University Of California Method for treatment of retinal diseases
KR20010014384A (ko) 1997-07-02 2001-02-26 모리타 다카카즈 폴리락트산 공막 플러그
DE69827138T2 (de) * 1997-08-11 2006-02-23 Allergan, Inc., Irvine Steriles Retinoid enthaltendes biodegradierbares Implantat mit verbesserter Biokompatibilität und Verfahren zu dessen Herstellung
ES2240180T3 (es) * 1999-10-21 2005-10-16 Alcon Inc. Administracion sub-tenon de medicamentos.
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20010049369A1 (en) * 2000-02-10 2001-12-06 Jablonski Monica M. Brimonidine compositions and methods for retinal degeneration
US6692759B1 (en) * 2000-06-28 2004-02-17 The Regents Of The University Of California Methods for preparing and using implantable substance delivery devices
AU2002248284A1 (en) 2000-11-01 2002-08-06 Allergan, Inc. Compositions for treatment of ocular neovascularization
ES2250504T3 (es) * 2000-11-29 2006-04-16 Allergan Inc. Prevencion del rechazo de injerto en el ojo.
JP5170935B2 (ja) * 2001-11-14 2013-03-27 デュレクト コーポレーション 注入可能なデポー組成物
US20060216328A1 (en) 2002-03-18 2006-09-28 Kis Gyorgy L Topical composition comprising a cyclofructan, a carrier and a drug
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
JP4463681B2 (ja) * 2002-07-15 2010-05-19 アルコン,インコーポレイテッド 眼内使用のための非ポリマー親油性薬学的インプラント組成物
US6899717B2 (en) * 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
PL376347A1 (en) * 2002-10-08 2005-12-27 Allergan, Inc. Method of using (2-imidazolin-2-ylamino) qinoxalines in the treatment of dementia and parkinsons
PL377333A1 (pl) * 2002-11-06 2006-01-23 Alza Corporation Preparaty depot o kontrolowanym uwalnianiu
AR042917A1 (es) 2003-01-24 2005-07-06 Control Delivery Sys Inc Dispositivo de liberacion sostenida para la administracion ocular de agentes adrenergicos y uso de agentes adrenergicos para su preparacion
JP2005035235A (ja) * 2003-07-18 2005-02-10 Noritsu Koki Co Ltd 画像露光装置
US20050131372A1 (en) * 2003-12-10 2005-06-16 Kimberly-Clark Worldwide, Inc. Absorbent articles with removable protective wing portions
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US8529927B2 (en) * 2004-04-30 2013-09-10 Allergan, Inc. Alpha-2 agonist polymeric drug delivery systems
US20060182781A1 (en) * 2004-04-30 2006-08-17 Allergan, Inc. Methods for treating ocular conditions with cyclic lipid contraining microparticles
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US7135391B2 (en) * 2004-05-21 2006-11-14 International Business Machines Corporation Polycrystalline SiGe junctions for advanced devices
US7931909B2 (en) * 2005-05-10 2011-04-26 Allergan, Inc. Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
EA202192521A1 (ru) 2019-04-23 2022-02-08 Рэйли С.Р.Л. Модульное ограждение, пригодное для установки с переменным наклоном
US11902105B2 (en) 2022-05-24 2024-02-13 Red Hat, Inc. Interactive graphical user interface for visualizing flow data in a programmable network switch

Also Published As

Publication number Publication date
US9861576B2 (en) 2018-01-09
US20160030334A1 (en) 2016-02-04
AU2018202557B2 (en) 2020-02-27
US10842739B2 (en) 2020-11-24
US20200069578A1 (en) 2020-03-05
CA2743837C (en) 2017-03-28
EP2355795A2 (en) 2011-08-17
US20170100334A1 (en) 2017-04-13
US20210161809A1 (en) 2021-06-03
US20100124565A1 (en) 2010-05-20
JP2012509264A (ja) 2012-04-19
WO2010056598A3 (en) 2010-12-23
US9095506B2 (en) 2015-08-04
JP5580832B2 (ja) 2014-08-27
US10471004B2 (en) 2019-11-12
JP2014184348A (ja) 2014-10-02
WO2010056598A2 (en) 2010-05-20
AU2018202557A1 (en) 2018-05-10
US20230285279A1 (en) 2023-09-14
AU2009314266A1 (en) 2010-05-20
AU2016204582A1 (en) 2016-07-21
CA2743837A1 (en) 2010-05-20
EP2355795B1 (en) 2017-01-04
US9522113B2 (en) 2016-12-20
US20180353426A1 (en) 2018-12-13

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