ES2623452T3 - Método y dispositivo para la determinación nefelométrica de un analito - Google Patents
Método y dispositivo para la determinación nefelométrica de un analito Download PDFInfo
- Publication number
- ES2623452T3 ES2623452T3 ES14185251.7T ES14185251T ES2623452T3 ES 2623452 T3 ES2623452 T3 ES 2623452T3 ES 14185251 T ES14185251 T ES 14185251T ES 2623452 T3 ES2623452 T3 ES 2623452T3
- Authority
- ES
- Spain
- Prior art keywords
- light
- path
- determination
- light intensity
- interval
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 title claims abstract description 27
- 239000012491 analyte Substances 0.000 title claims abstract description 26
- 238000005259 measurement Methods 0.000 claims abstract description 40
- 230000003287 optical effect Effects 0.000 claims abstract description 31
- 238000006073 displacement reaction Methods 0.000 claims abstract description 11
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 5
- 238000004458 analytical method Methods 0.000 claims description 14
- 239000013590 bulk material Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 51
- 239000000523 sample Substances 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 9
- 230000000630 rising effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000000903 blocking effect Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 230000004308 accommodation Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
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- 238000011156 evaluation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000004848 nephelometry Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 231100000289 photo-effect Toxicity 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
- G01N21/474—Details of optical heads therefor, e.g. using optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/075—Investigating concentration of particle suspensions by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4707—Forward scatter; Low angle scatter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00207—Handling bulk quantities of analyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
- G01N2201/0612—Laser diodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/068—Optics, miscellaneous
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Plasma & Fusion (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14185251.7A EP2998726B1 (de) | 2014-09-18 | 2014-09-18 | Verfahren und Vorrichtung zur nephelometrischen Bestimmung eines Analyten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2623452T3 true ES2623452T3 (es) | 2017-07-11 |
Family
ID=51582263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14185251.7T Active ES2623452T3 (es) | 2014-09-18 | 2014-09-18 | Método y dispositivo para la determinación nefelométrica de un analito |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10684228B2 (enExample) |
| EP (1) | EP2998726B1 (enExample) |
| JP (1) | JP6422414B2 (enExample) |
| CN (1) | CN105445231B (enExample) |
| ES (1) | ES2623452T3 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108007892A (zh) * | 2016-10-28 | 2018-05-08 | 湖南汇锋高新能源有限公司 | 钒电解液中氯离子的测定方法 |
| JP2023088157A (ja) * | 2021-12-14 | 2023-06-26 | 横河電機株式会社 | 濁度計及び濁度測定方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5960323A (ja) * | 1982-09-30 | 1984-04-06 | Toshiba Corp | 測光装置 |
| ES2150442T3 (es) * | 1992-03-27 | 2000-12-01 | Abbott Lab | Cubeta de ensayo de materia plastica que presenta una birrefringencia baja. |
| US5646049A (en) * | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
| US5940178A (en) * | 1996-07-03 | 1999-08-17 | Beckman Instruments, Inc. | Nephelometer and turbidimeter combination |
| DE19849597A1 (de) * | 1998-10-28 | 2000-05-04 | Dade Behring Marburg Gmbh | Nephelometrische Detektionseinheit mit optischer In-Prozeß-Kontrolle |
| JP3794012B2 (ja) * | 1999-03-10 | 2006-07-05 | 日本電子株式会社 | 回転反応器の測定方式 |
| DE19948587A1 (de) * | 1999-10-08 | 2001-04-12 | Dade Behring Marburg Gmbh | Spektralphotometrische und nephelometrische Detektionseinheit |
| US6519355B2 (en) * | 2001-03-28 | 2003-02-11 | Alan C. Nelson | Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease |
| US7804594B2 (en) * | 2006-12-29 | 2010-09-28 | Abbott Laboratories, Inc. | Method and apparatus for rapidly counting and identifying biological particles in a flow stream |
| US8159670B2 (en) * | 2007-11-05 | 2012-04-17 | Abbott Laboratories | Method and apparatus for rapidly counting and identifying biological particles in a flow stream |
| WO2009122993A1 (ja) | 2008-03-31 | 2009-10-08 | シスメックス株式会社 | 血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム |
| DE102009043524A1 (de) * | 2009-09-30 | 2011-03-31 | Siemens Healthcare Diagnostics Products Gmbh | Vorrichtung für die photometrische Untersuchung von Proben |
-
2014
- 2014-09-18 ES ES14185251.7T patent/ES2623452T3/es active Active
- 2014-09-18 EP EP14185251.7A patent/EP2998726B1/de active Active
-
2015
- 2015-09-11 US US14/852,482 patent/US10684228B2/en active Active
- 2015-09-11 CN CN201510580675.2A patent/CN105445231B/zh active Active
- 2015-09-17 JP JP2015183529A patent/JP6422414B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105445231A (zh) | 2016-03-30 |
| US10684228B2 (en) | 2020-06-16 |
| EP2998726B1 (de) | 2017-01-25 |
| EP2998726A1 (de) | 2016-03-23 |
| JP6422414B2 (ja) | 2018-11-14 |
| JP2016061790A (ja) | 2016-04-25 |
| CN105445231B (zh) | 2020-12-08 |
| US20160084770A1 (en) | 2016-03-24 |
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