ES2619370T3 - Anticuerpos monoclonales contra el Virus de la Inmunodeficiencia Humana y usos de los mismos - Google Patents

Anticuerpos monoclonales contra el Virus de la Inmunodeficiencia Humana y usos de los mismos Download PDF

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Publication number
ES2619370T3
ES2619370T3 ES10179020.2T ES10179020T ES2619370T3 ES 2619370 T3 ES2619370 T3 ES 2619370T3 ES 10179020 T ES10179020 T ES 10179020T ES 2619370 T3 ES2619370 T3 ES 2619370T3
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ES
Spain
Prior art keywords
hiv
antibody
antigen
complexes
test sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10179020.2T
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English (en)
Spanish (es)
Inventor
Sheng C. Lou
Jeffrey C. Hunt
John G. Konrath
Xiaoxing Qiu
James W. Scheffel
Joan D. Tyner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2619370T3 publication Critical patent/ES2619370T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1143—Gag-pol proteins, e.g. p17or p24
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/161—HIV-1 ; HIV-2 gag-pol, e.g. p55, p24/25, p17/18, p7, p6, p66/68, p51/52, p31/34, p32, p40
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES10179020.2T 2000-12-06 2001-12-05 Anticuerpos monoclonales contra el Virus de la Inmunodeficiencia Humana y usos de los mismos Expired - Lifetime ES2619370T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US731126 2000-12-06
US09/731,126 US6818392B2 (en) 2000-12-06 2000-12-06 Monoclonal antibodies to human immunodeficiency virus and uses thereof

Publications (1)

Publication Number Publication Date
ES2619370T3 true ES2619370T3 (es) 2017-06-26

Family

ID=24938175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10179020.2T Expired - Lifetime ES2619370T3 (es) 2000-12-06 2001-12-05 Anticuerpos monoclonales contra el Virus de la Inmunodeficiencia Humana y usos de los mismos

Country Status (6)

Country Link
US (10) US6818392B2 (https=)
EP (2) EP2336175B1 (https=)
JP (1) JP4489351B2 (https=)
CA (1) CA2431321C (https=)
ES (1) ES2619370T3 (https=)
WO (1) WO2002064615A2 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818392B2 (en) 2000-12-06 2004-11-16 Abbott Laboratories Monoclonal antibodies to human immunodeficiency virus and uses thereof
US20050054118A1 (en) * 2002-02-27 2005-03-10 Lebrun Stewart J. High throughput screening method
WO2003072752A2 (en) * 2002-02-27 2003-09-04 Miragene, Inc. Improved substrate chemistry for protein immobilization on a rigid support
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
WO2008059553A1 (en) * 2006-11-13 2008-05-22 Masami Moriyama Method for detecting hiv-1 without being affected by anti-mouse protein antibody existing in human and kit to be used for the same
FI120376B (fi) * 2007-01-17 2009-09-30 Next Biomed Technologies Nbt O Menetelmä biomuokatun, korkean affiniteetin polypeptidin valmistamiseksi
US20090181359A1 (en) 2007-10-25 2009-07-16 Lou Sheng C Method of performing ultra-sensitive immunoassays
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
BRPI0910482A2 (pt) 2008-04-29 2019-09-24 Abbott Lab imunoglobinas de domínio variável duplo e usos das mesmas
PE20100092A1 (es) 2008-06-03 2010-03-12 Abbott Lab Inmunoglobulina con dominio variable dual y usos de la misma
BRPI0913366A8 (pt) 2008-06-03 2017-07-11 Abbott Lab Imunoglobulinas de domínio variável duplo e seus usos
NZ603698A (en) 2008-07-08 2014-03-28 Abbvie Inc Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
JP2012503771A (ja) * 2008-09-25 2012-02-09 デューク ユニバーシティー 抗体および抗体−ｈｉｖビリオン複合体を検出する方法
US8916154B2 (en) * 2009-04-27 2014-12-23 Abbott Laboratories Antibodies against delta-5 desaturase and uses thereof
EP2424566A4 (en) * 2009-05-01 2013-07-31 Abbvie Inc IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE
US20100297778A1 (en) * 2009-05-20 2010-11-25 Abbott Laboratories Conjugate Having Cleavable Linking Agent
ES2639411T3 (es) 2009-09-15 2017-10-26 Gemini Research Limited Detección de autoanticuerpos contra antígenos nucleares
AU2010306677B2 (en) * 2009-10-15 2013-05-23 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
EP2550362B1 (en) 2010-03-25 2017-01-04 Oregon Health&Science University Cmv glycoproteins and recombinant vectors
US8735546B2 (en) 2010-08-03 2014-05-27 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
CA2809363A1 (en) * 2010-08-24 2012-03-01 Abbott Laboratories Hiv core protein specific antibodies and uses thereof
PE20140229A1 (es) 2010-08-26 2014-03-27 Abbvie Inc Inmunoglobulinas con dominio variable dual y usos de las mismas
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
US20130064811A1 (en) * 2011-09-09 2013-03-14 International Business Machines Corporation Methods to Enhance Cancer Treatment
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
AR089529A1 (es) 2011-12-30 2014-08-27 Abbvie Inc Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
EP2679596B1 (en) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 env glycoprotein variant
KR20180008921A (ko) 2012-11-01 2018-01-24 애브비 인코포레이티드 항-ｖｅｇｆ／ｄｌｌ4 이원 가변 도메인 면역글로불린 및 이의 용도
CN105324396A (zh) 2013-03-15 2016-02-10 艾伯维公司 针对IL-1β和/或IL-17的双重特异性结合蛋白
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
CN105929157A (zh) * 2016-05-25 2016-09-07 苏州新波生物技术有限公司 一种联合检测hiv抗原抗体的诊断试剂盒及其制备方法
US20200209226A1 (en) * 2017-01-20 2020-07-02 Shenzhen New Industries Biomedical Engineering Co. Labeled complex, preparation method thereof, kit containing the same, application of kit and detection system comprising kit
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
JP7810694B2 (ja) * 2020-07-13 2026-02-03 グリフォルス ダイアグノステック ソリューションズ インコーポレーテッド 抗ヒト免疫不全ウイルス－１抗体及びその使用方法
CN119390828A (zh) * 2024-12-31 2025-02-07 天津龙晟生物科技有限公司 人类免疫缺陷病毒hiv抗体及其应用和其检测产品

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3006207C2 (de) 1980-02-15 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Elektrische Maschine mit einem Ständerblechpaket aus kornorientierten Blechen
CA1341482C (en) 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
DE3445816C1 (de) 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flaechenfoermiges diagnostisches Mittel
US4839288A (en) * 1986-01-22 1989-06-13 Institut Pasteur Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes
ZA873215B (en) 1986-05-19 1987-10-28 Viral Technologies Inc. Htlv-iii/lav virus related peptides,antibodies to the peptides,vaccines,passive and active immunization against aids virus and diagnostic test for the serological detection of aids virus
DE3636540A1 (de) 1986-10-27 1988-04-28 Behringwerke Ag Verfahren zur bestimmung von anti-hiv, mittel dazu und ihre verwendung in diesem verfahren
DE3705686C2 (de) 1987-02-23 1995-11-30 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Antikörpern
US5104790A (en) 1987-06-29 1992-04-14 Genetic Systems Corporation Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use
US4886742A (en) 1987-06-15 1989-12-12 Coulter Corporation Enzyme immunoassay for detecting HIV antigens in human sera
US4888290A (en) 1987-11-06 1989-12-19 Coulter Corporation Monoclonal antibody specific to HIV antigens
DE3819079A1 (de) 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
EP0657532B1 (en) 1988-06-09 2003-12-17 N.V. Innogenetics S.A. HIV-3 retrovirus strains and their use
US5173399A (en) * 1988-06-10 1992-12-22 Abbott Laboratories Mouse monoclonal antibodies to hiv-1p24 and their use in diagnostic tests
CA1335880C (en) 1988-07-14 1995-06-13 Thomas P. O'connor Detection of an antibody and antigen in an immunoassay
US5731189A (en) 1989-02-28 1998-03-24 New York University Human monoclonal antibodies to human immunodeficiency virus
EP0386713B1 (en) 1989-03-09 1996-09-18 Abbott Laboratories Immunoassay for antibodies to HIV
ZA903492B (en) 1989-05-15 1991-02-27 Akzo Nv T-lymphotropic retrovirus monoclonal antibodies
US5210181A (en) * 1989-05-15 1993-05-11 Akzo N.V. T-lymphotropic retrovirus peptide
JPH0831392B2 (ja) * 1990-04-26 1996-03-27 株式会社村田製作所 積層コンデンサ
DE4039925A1 (de) 1990-12-14 1992-06-17 Behringwerke Ag Ausgewaehlte peptide des gruppenspezifischen antigens (gag) von humanem immundefizienzvirus (hiv), ihre herstellung und verwendung
EP0519866A1 (en) 1991-06-18 1992-12-23 Ciba-Geigy Ag Novel anti-HIV antibodies
EP0644950A4 (en) 1992-04-09 1997-05-14 Abbott Lab ASSAY FOR THE DETECTION OF HIV ANTIGEN AND HIV ANTIBODIES.
DE4236189A1 (de) 1992-10-27 1994-04-28 Boehringer Mannheim Gmbh Verfahren zur simultanen Bestimmung von Antigenen und Antikörpern
EP0627625A1 (en) 1993-06-04 1994-12-07 Abbott Laboratories Immunoassay for differential diagnosis
US5611253A (en) * 1993-09-07 1997-03-18 Tohoku Ricoh Co., Ltd. Cutting device
AU1880995A (en) 1994-03-02 1995-09-18 Abbott Laboratories Hiv immunoassay utilizing recombinant protein and synthetic peptide reagents
CA2195753C (en) 1994-07-25 2008-12-16 Ursula-Henrike Wienhues Determination of a specific immunoglobulin using multiple antigens
NZ291155A (en) 1994-07-25 1997-09-22 Boehringer Mannheim Gmbh Production of hapten labelled peptides and their use
AU689626B2 (en) 1994-07-25 1998-04-02 Boehringer Mannheim Gmbh Peptides marked with metal chelates
CN1651457B (zh) 1994-10-20 2010-07-28 巴斯德研究所 Hiv-1 o组(或亚组)逆转录病毒抗原的核苷酸序列
US6015662A (en) 1996-01-23 2000-01-18 Abbott Laboratories Reagents for use as calibrators and controls
AU6727798A (en) 1997-03-10 1998-09-29 Roche Diagnostics Gmbh Method for simultaneous detection of hiv antigens and hiv antibodies
DE19727943A1 (de) 1997-03-10 1998-09-24 Boehringer Mannheim Gmbh Verfahren zur simultanen Bestimmung von HIV-Antigenen und HIV-Antikörpern
US6596302B2 (en) 2000-04-13 2003-07-22 Abbott Laboratories Infant formulas containing long-chain polyunsaturated fatty acids and uses thereof
US6818392B2 (en) * 2000-12-06 2004-11-16 Abbott Laboratories Monoclonal antibodies to human immunodeficiency virus and uses thereof
CA2809363A1 (en) * 2010-08-24 2012-03-01 Abbott Laboratories Hiv core protein specific antibodies and uses thereof

Also Published As

Publication number Publication date
US20050031624A1 (en) 2005-02-10
US7897332B2 (en) 2011-03-01
WO2002064615A3 (en) 2003-04-17
US20130130233A1 (en) 2013-05-23
US20050053925A1 (en) 2005-03-10
EP2336175B1 (en) 2017-01-18
CA2431321C (en) 2012-05-29
US20020106636A1 (en) 2002-08-08
US6818392B2 (en) 2004-11-16
US7531641B2 (en) 2009-05-12
EP2336175A1 (en) 2011-06-22
US20050053924A1 (en) 2005-03-10
EP1341820A2 (en) 2003-09-10
US7528238B2 (en) 2009-05-05
US9115189B2 (en) 2015-08-25
US7531642B2 (en) 2009-05-12
JP4489351B2 (ja) 2010-06-23
US7531639B2 (en) 2009-05-12
US20040101831A1 (en) 2004-05-27
JP2004536568A (ja) 2004-12-09
US20050058994A1 (en) 2005-03-17
CA2431321A1 (en) 2002-08-22
US20050053610A1 (en) 2005-03-10
US7531638B2 (en) 2009-05-12
US20120100632A1 (en) 2012-04-26
US7531640B2 (en) 2009-05-12
US20050025772A1 (en) 2005-02-03
WO2002064615A2 (en) 2002-08-22

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