ES2608462T3 - Unidad de jeringa mejorada - Google Patents
Unidad de jeringa mejorada Download PDFInfo
- Publication number
- ES2608462T3 ES2608462T3 ES13708230.1T ES13708230T ES2608462T3 ES 2608462 T3 ES2608462 T3 ES 2608462T3 ES 13708230 T ES13708230 T ES 13708230T ES 2608462 T3 ES2608462 T3 ES 2608462T3
- Authority
- ES
- Spain
- Prior art keywords
- volume
- cylinder
- plug
- cap
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012530 fluid Substances 0.000 claims abstract description 111
- 239000003814 drug Substances 0.000 claims abstract description 61
- 229940079593 drug Drugs 0.000 claims abstract description 46
- 238000007789 sealing Methods 0.000 claims abstract description 20
- 238000002483 medication Methods 0.000 claims abstract description 16
- 238000004891 communication Methods 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims description 32
- 230000000295 complement effect Effects 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 229940090047 auto-injector Drugs 0.000 claims description 2
- 238000002347 injection Methods 0.000 description 17
- 239000007924 injection Substances 0.000 description 17
- 238000002156 mixing Methods 0.000 description 17
- 239000000203 mixture Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000005755 formation reaction Methods 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 4
- 238000007667 floating Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000002457 bidirectional effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- RLLPVAHGXHCWKJ-IEBWSBKVSA-N (3-phenoxyphenyl)methyl (1s,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-IEBWSBKVSA-N 0.000 description 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- 241001444201 Falco tinnunculus Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
- A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3294—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles comprising means for injection of two or more media, e.g. by mixing
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201203015 | 2012-02-22 | ||
| GB1203015.1A GB2499612A (en) | 2012-02-22 | 2012-02-22 | Syringe assembly with a stopper |
| PCT/GB2013/050438 WO2013124669A1 (en) | 2012-02-22 | 2013-02-22 | Improved syringe assembly |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2608462T3 true ES2608462T3 (es) | 2017-04-11 |
Family
ID=45939986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13708230.1T Active ES2608462T3 (es) | 2012-02-22 | 2013-02-22 | Unidad de jeringa mejorada |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9962492B2 (enExample) |
| EP (1) | EP2817043B1 (enExample) |
| JP (1) | JP6381447B2 (enExample) |
| CN (1) | CN104144720B (enExample) |
| AU (1) | AU2013223804B2 (enExample) |
| CA (1) | CA2864405C (enExample) |
| CY (1) | CY1118558T1 (enExample) |
| DK (1) | DK2817043T3 (enExample) |
| ES (1) | ES2608462T3 (enExample) |
| GB (1) | GB2499612A (enExample) |
| HU (1) | HUE032473T2 (enExample) |
| IN (1) | IN2014DN07272A (enExample) |
| LT (1) | LT2817043T (enExample) |
| PL (1) | PL2817043T3 (enExample) |
| PT (1) | PT2817043T (enExample) |
| SI (1) | SI2817043T1 (enExample) |
| WO (1) | WO2013124669A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10569017B2 (en) | 2013-03-15 | 2020-02-25 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| CA2905207C (en) | 2013-03-15 | 2022-04-12 | Brent Buchine | Portable drug mixing and delivery system and method |
| US12239822B2 (en) | 2013-03-15 | 2025-03-04 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| US9907910B2 (en) | 2013-03-15 | 2018-03-06 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
| US20140276379A1 (en) | 2013-03-15 | 2014-09-18 | Medrad, Inc. | Intelligent and configurable fluid delivery system and methods for its use |
| GB201305489D0 (en) * | 2013-03-26 | 2013-05-08 | Consort Medical Plc | Improved syringe assembly |
| CN106061253A (zh) | 2013-12-18 | 2016-10-26 | 温德加普医疗股份有限公司 | 药物混合和递送系统及方法 |
| US11116903B2 (en) | 2014-08-18 | 2021-09-14 | Windgap Medical, Inc | Compression seal for use with a liquid component storage vial of an auto-injector |
| CN106794305B (zh) | 2014-08-18 | 2021-02-23 | 温德加普医疗股份有限公司 | 便携式药物混合和递送装置及操作药物混合装置的方法 |
| AU2015364280A1 (en) | 2014-12-18 | 2017-07-06 | Windgap Medical, Inc. | Method and compositions for dissolving or solubilizing therapeutic agents |
| US10744265B2 (en) | 2014-12-30 | 2020-08-18 | Kindeva Drug Delivery L.P. | Container for mixing and dispensing components |
| KR102512255B1 (ko) * | 2014-12-30 | 2023-03-20 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 2가지 성분을 혼합 및 분배하기 위한 용기 |
| KR102450955B1 (ko) * | 2014-12-30 | 2022-10-04 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 유체 약제 성분들을 혼합 및 분배하기 위한 용기 |
| JP6580777B2 (ja) | 2015-08-13 | 2019-09-25 | ウィンドギャップ メディカル， インコーポレイテッド | 無菌特徴を有する混合及び注入装置 |
| AU2017345171B2 (en) * | 2016-10-17 | 2023-01-05 | Bayer Healthcare Llc | Fluid control valve and manifold |
| DE102017125703A1 (de) | 2016-11-04 | 2018-05-09 | Datwyler Pharma Packaging International Nv | Im Kunststoff-Spritzverfahren hergestellter Kolben für eine medizinische Spritze und eine medizinische Spritze |
| JP6856840B2 (ja) | 2016-12-27 | 2021-04-14 | アクション メディカル テクノロジーズ，エルエルシーＡｃｔｉｏｎ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ，Ｌｌｃ | 注入器、および注入器を動作させる方法 |
| US10493207B2 (en) * | 2017-02-27 | 2019-12-03 | W. L. Gore & Associates, Inc. | Medical delivery devices having low lubricant syringe barrels |
| US11224696B2 (en) | 2018-07-10 | 2022-01-18 | Action Medical Technologies, Llc | Apparatuses and method for injecting medicaments |
| ES2981762T3 (es) * | 2020-03-17 | 2024-10-10 | Becton Dickinson France | Tapón para un dispositivo de inyección médica |
| WO2021195310A1 (en) | 2020-03-25 | 2021-09-30 | Action Medical Technolgies, Llc | Apparatuses and methods for injecting medicaments |
| US11759576B2 (en) | 2020-06-05 | 2023-09-19 | Action Medical Technologies, Llc | Parenteral injection apparatus |
| KR102742097B1 (ko) | 2020-12-23 | 2024-12-11 | 톨마 인터내셔날 리미티드 | 혼합 주사기 밸브 어셈블리를 위한 시스템 및 방법 |
| US20240285860A1 (en) | 2021-06-15 | 2024-08-29 | Sadleir Laboratories Pty Ltd | Medication delivery systems, apparatuses and methods |
| CN118973641A (zh) * | 2022-04-04 | 2024-11-15 | 贝克顿·迪金森公司 | 用于顺序地输送流体的具有压力阀的多腔室注射器及其使用方法 |
| USD1029245S1 (en) | 2022-06-22 | 2024-05-28 | Tolmar International Limited | Syringe connector |
| US20240226436A9 (en) * | 2022-10-25 | 2024-07-11 | Becton, Dickinson And Company | Barrier Coated Sequential Stopper for a Multi-Chamber Syringe |
| GB2629028A (en) * | 2023-04-14 | 2024-10-16 | Salinity Solutions Ltd | Membrane filtration system |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3076456A (en) * | 1960-03-07 | 1963-02-05 | Elsie B Hunt | Hypodermic syringe |
| US3699961A (en) * | 1970-03-12 | 1972-10-24 | Sebon Corp The | Syringe and method |
| US3914419A (en) * | 1973-08-02 | 1975-10-21 | American Cyanamid Co | Two compartment one unit consecutively injectable liquid vitamin package |
| EP0112574A1 (fr) * | 1982-12-27 | 1984-07-04 | Meditec S.A. | Seringue préremplie à double compartiment |
| CH666870A5 (fr) * | 1986-04-10 | 1988-08-31 | Cosmonor Sa | Dispositif de conditionnement de substances liquides ou liquides et solides. |
| US4929230A (en) * | 1988-09-30 | 1990-05-29 | Pfleger Frederick W | Syringe construction |
| US5078691A (en) * | 1990-03-01 | 1992-01-07 | Hamacher Edward N | Multiple-dose fluid delivery system and method |
| GB9223183D0 (en) | 1992-11-05 | 1992-12-16 | Medimech Int Ltd | Improvements related to auto injectors |
| NZ332673A (en) | 1996-05-03 | 2000-01-28 | Nordway Ltd | Vial for use as syringe accessory |
| FR2750051A1 (fr) * | 1996-06-21 | 1997-12-26 | Debiotech Sa | Seringue medicale a piston libre |
| US5713857A (en) * | 1996-06-28 | 1998-02-03 | Becton Dickinson France, S.A. | Sequential stopper |
| FR2793708B1 (fr) * | 1999-05-21 | 2001-08-03 | Valois Sa | Dispositif de distribution de produit fluide |
| US6953445B2 (en) | 2000-10-10 | 2005-10-11 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
| AR026723A1 (es) * | 2000-12-05 | 2003-02-26 | Szames Leonardo | Conjunto valvular elastico y deslizante apto para actuar en el interior de jeringas prellenadas. |
| US6387078B1 (en) * | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
| US7077827B2 (en) | 2002-08-30 | 2006-07-18 | Christian John Greenfield | Syringe for sequential delivery of different fluids |
| US6997910B2 (en) | 2004-05-03 | 2006-02-14 | Infusive Technologies, Llc | Multi-chamber, sequential dose dispensing syringe |
| JP2008259704A (ja) * | 2007-04-12 | 2008-10-30 | Hisamitsu Pharmaceut Co Inc | プレフィルド型シリンジ |
| JP5658039B2 (ja) | 2008-01-17 | 2015-01-21 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 物質混合用バルブ |
-
2012
- 2012-02-22 GB GB1203015.1A patent/GB2499612A/en not_active Withdrawn
-
2013
- 2013-02-22 CN CN201380010440.9A patent/CN104144720B/zh active Active
- 2013-02-22 PL PL13708230T patent/PL2817043T3/pl unknown
- 2013-02-22 HU HUE13708230A patent/HUE032473T2/en unknown
- 2013-02-22 EP EP13708230.1A patent/EP2817043B1/en active Active
- 2013-02-22 IN IN7272DEN2014 patent/IN2014DN07272A/en unknown
- 2013-02-22 WO PCT/GB2013/050438 patent/WO2013124669A1/en not_active Ceased
- 2013-02-22 JP JP2014558208A patent/JP6381447B2/ja active Active
- 2013-02-22 PT PT137082301T patent/PT2817043T/pt unknown
- 2013-02-22 LT LTEP13708230.1T patent/LT2817043T/lt unknown
- 2013-02-22 US US14/380,334 patent/US9962492B2/en active Active
- 2013-02-22 DK DK13708230.1T patent/DK2817043T3/en active
- 2013-02-22 CA CA2864405A patent/CA2864405C/en active Active
- 2013-02-22 AU AU2013223804A patent/AU2013223804B2/en active Active
- 2013-02-22 SI SI201330478A patent/SI2817043T1/sl unknown
- 2013-02-22 ES ES13708230.1T patent/ES2608462T3/es active Active
-
2017
- 2017-01-05 CY CY20171100016T patent/CY1118558T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2817043T (pt) | 2017-01-19 |
| AU2013223804B2 (en) | 2017-07-13 |
| IN2014DN07272A (enExample) | 2015-04-24 |
| AU2013223804A1 (en) | 2014-09-11 |
| HUE032473T2 (en) | 2017-10-30 |
| CA2864405C (en) | 2020-06-02 |
| PL2817043T3 (pl) | 2017-06-30 |
| JP6381447B2 (ja) | 2018-08-29 |
| DK2817043T3 (en) | 2017-01-30 |
| US20150011975A1 (en) | 2015-01-08 |
| CN104144720A (zh) | 2014-11-12 |
| GB2499612A (en) | 2013-08-28 |
| CY1118558T1 (el) | 2017-07-12 |
| WO2013124669A1 (en) | 2013-08-29 |
| EP2817043A1 (en) | 2014-12-31 |
| JP2015507997A (ja) | 2015-03-16 |
| GB201203015D0 (en) | 2012-04-04 |
| EP2817043B1 (en) | 2016-10-26 |
| SI2817043T1 (sl) | 2017-03-31 |
| CA2864405A1 (en) | 2013-08-29 |
| LT2817043T (lt) | 2017-02-10 |
| US9962492B2 (en) | 2018-05-08 |
| CN104144720B (zh) | 2016-11-09 |
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