ES2606350T3 - Marcadores epigenéticos para la identificación de linfocitos T CD3 positivos - Google Patents
Marcadores epigenéticos para la identificación de linfocitos T CD3 positivos Download PDFInfo
- Publication number
- ES2606350T3 ES2606350T3 ES09771304.4T ES09771304T ES2606350T3 ES 2606350 T3 ES2606350 T3 ES 2606350T3 ES 09771304 T ES09771304 T ES 09771304T ES 2606350 T3 ES2606350 T3 ES 2606350T3
- Authority
- ES
- Spain
- Prior art keywords
- lymphocytes
- identification
- positive
- memory
- intact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 5
- 230000001973 epigenetic effect Effects 0.000 title 1
- 108091093088 Amplicon Proteins 0.000 abstract 2
- 230000011987 methylation Effects 0.000 abstract 2
- 238000007069 methylation reaction Methods 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08021838 | 2008-12-16 | ||
| EP20080021838 EP2199411B1 (en) | 2008-12-16 | 2008-12-16 | Epigenetic markers for the identification of CD3 positive T-lymphocytes |
| PCT/EP2009/008764 WO2010069499A2 (en) | 2008-12-16 | 2009-12-08 | Epigenetic markers for the identification of blood sub-cells of type 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2606350T3 true ES2606350T3 (es) | 2017-03-23 |
Family
ID=40428037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09771304.4T Active ES2606350T3 (es) | 2008-12-16 | 2009-12-08 | Marcadores epigenéticos para la identificación de linfocitos T CD3 positivos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120107810A1 (https=) |
| EP (2) | EP2199411B1 (https=) |
| JP (1) | JP2012511917A (https=) |
| CA (1) | CA2747312C (https=) |
| DK (2) | DK2199411T3 (https=) |
| ES (1) | ES2606350T3 (https=) |
| PL (1) | PL2376648T3 (https=) |
| WO (1) | WO2010069499A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170233807A1 (en) | 2008-12-16 | 2017-08-17 | Epiontis Gmbh | Epigenetic Markers for the Identification of Blood Sub-cells of Type 1 |
| US20130281304A1 (en) * | 2010-08-13 | 2013-10-24 | Andrew P. Feinberg | Comprehensive Methylome Map of Myeloid and Lymphoid Commitment from Hematopoietic Proenitors |
| WO2012045888A1 (en) | 2010-10-08 | 2012-04-12 | Epiontis Gmbh | Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes |
| JP2014505475A (ja) * | 2011-01-20 | 2014-03-06 | ユニヴェルシテ リブル ドゥ ブリュッセル | ヒトの乳癌のエピジェネティックな肖像 |
| US20140178348A1 (en) | 2011-05-25 | 2014-06-26 | The Regents Of The University Of California | Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| CA2869295A1 (en) * | 2011-05-25 | 2012-11-29 | Brown University | Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| WO2013135454A1 (en) * | 2012-03-12 | 2013-09-19 | Epiontis Gmbh | Epigenetic marker for the identification of cd3cd4 positive t lymphocytes |
| GB201221133D0 (en) * | 2012-11-23 | 2013-01-09 | Epiontis Gmbh | Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes |
| JP6590790B2 (ja) | 2013-04-19 | 2019-10-16 | エピオンティス ゲーエムベーハー | 生体サンプルにおける定量的細胞組成を特定する方法 |
| EP3360971A1 (en) * | 2017-02-09 | 2018-08-15 | Epiontis GmbH | Improved method for epigenetic immune cell counting |
| EP3382033B1 (en) * | 2017-03-30 | 2020-08-05 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Method for determining blood counts based on dna methylation |
| DE102017125019B4 (de) * | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | PDCD1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere PD1+ Zellen |
| DE102018116353B4 (de) * | 2018-07-05 | 2020-06-10 | Epiontis Gmbh | Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening |
| CN116949156B (zh) * | 2023-09-19 | 2023-12-08 | 美迪西普亚医药科技(上海)有限公司 | 一种基于核酸变体的通用型检测人t细胞的分析方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002171973A (ja) * | 2000-12-07 | 2002-06-18 | Univ Tokyo | Ｄｎａメチル化パターンによる細胞の同定法 |
| WO2004050706A2 (en) | 2002-12-03 | 2004-06-17 | Medical Research Council | Regulatory t-cells |
| ES2367012T3 (es) | 2006-02-28 | 2011-10-27 | Charite-Universitätsmedizin Berlin | Detección y control de calidad de linfocitos t reguladores a través del análisis de metilación del adn del gen foxp3. |
-
2008
- 2008-12-16 DK DK08021838.1T patent/DK2199411T3/en active
- 2008-12-16 EP EP20080021838 patent/EP2199411B1/en active Active
-
2009
- 2009-12-08 CA CA2747312A patent/CA2747312C/en active Active
- 2009-12-08 WO PCT/EP2009/008764 patent/WO2010069499A2/en not_active Ceased
- 2009-12-08 US US13/139,808 patent/US20120107810A1/en not_active Abandoned
- 2009-12-08 DK DK09771304.4T patent/DK2376648T3/da active
- 2009-12-08 EP EP09771304.4A patent/EP2376648B1/en active Active
- 2009-12-08 PL PL09771304T patent/PL2376648T3/pl unknown
- 2009-12-08 ES ES09771304.4T patent/ES2606350T3/es active Active
- 2009-12-08 JP JP2011541165A patent/JP2012511917A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2199411B1 (en) | 2015-05-06 |
| HK1163189A1 (zh) | 2012-09-07 |
| DK2199411T3 (en) | 2015-08-03 |
| WO2010069499A3 (en) | 2010-08-26 |
| WO2010069499A2 (en) | 2010-06-24 |
| PL2376648T3 (pl) | 2017-05-31 |
| DK2376648T3 (da) | 2017-01-02 |
| CA2747312C (en) | 2018-11-06 |
| CA2747312A1 (en) | 2010-06-24 |
| US20120107810A1 (en) | 2012-05-03 |
| EP2376648A2 (en) | 2011-10-19 |
| JP2012511917A (ja) | 2012-05-31 |
| EP2376648B1 (en) | 2016-09-14 |
| EP2199411A1 (en) | 2010-06-23 |
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