ES2599996T3 - Polipéptidos - Google Patents
Polipéptidos Download PDFInfo
- Publication number
- ES2599996T3 ES2599996T3 ES11194071.4T ES11194071T ES2599996T3 ES 2599996 T3 ES2599996 T3 ES 2599996T3 ES 11194071 T ES11194071 T ES 11194071T ES 2599996 T3 ES2599996 T3 ES 2599996T3
- Authority
- ES
- Spain
- Prior art keywords
- egfr
- zegfr
- his6
- cells
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 108010047303 von Willebrand Factor Proteins 0.000 description 1
- 102100036537 von Willebrand factor Human genes 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0524788.7A GB0524788D0 (en) | 2005-12-05 | 2005-12-05 | Polypeptides |
| GB0524788 | 2005-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2599996T3 true ES2599996T3 (es) | 2017-02-06 |
Family
ID=35686099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11194071.4T Active ES2599996T3 (es) | 2005-12-05 | 2006-12-05 | Polipéptidos |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8247375B2 (enExample) |
| EP (2) | EP2431383B1 (enExample) |
| JP (2) | JP5898826B2 (enExample) |
| CN (2) | CN101336250A (enExample) |
| CA (1) | CA2631430C (enExample) |
| DK (1) | DK2431383T3 (enExample) |
| ES (1) | ES2599996T3 (enExample) |
| GB (1) | GB0524788D0 (enExample) |
| WO (1) | WO2007065635A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| GEP20156390B (en) * | 2008-01-03 | 2015-11-10 | Scripps Research Inst | Antibody targeting through a modular recognition domain |
| JP5677943B2 (ja) | 2008-06-05 | 2015-02-25 | アフィボディ・アーベーＡｆｆｉｂｏｄｙ Ａｂ | ポリペプチド |
| EP2331140B1 (en) | 2008-08-11 | 2018-07-04 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| JP5960598B2 (ja) * | 2009-11-04 | 2016-08-02 | アフィボディ・アーベー | Ｈｅｒ３結合ポリペプチド |
| EA024507B1 (ru) | 2010-09-28 | 2016-09-30 | Амилин Фармасьютикалс, Ллк | Хорошо растворимые лептины |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| CN106432506A (zh) | 2011-05-24 | 2017-02-22 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| JP5812303B2 (ja) * | 2011-06-03 | 2015-11-11 | 国立研究開発法人産業技術総合研究所 | 酸性域での親和性が低下したプロテインａ変異型タンパク質及び抗体捕捉剤 |
| DK2729160T3 (da) | 2011-07-08 | 2019-07-01 | Aegerion Pharmaceuticals Inc | Manipulerede polypeptider, der har forbedret virkningstid og reduceret immunogenicitet |
| TWI443108B (zh) | 2011-12-28 | 2014-07-01 | Ind Tech Res Inst | 抗人類表皮生長因子受體抗體及其應用 |
| WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
| WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
| KR102191655B1 (ko) | 2012-10-05 | 2020-12-16 | 애피바디 에이비 | Her3 결합 폴리펩티드 |
| EP3666795A1 (en) | 2013-03-12 | 2020-06-17 | Molecular Templates, Inc. | Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types |
| EP3575312A1 (en) | 2014-01-27 | 2019-12-04 | Molecular Templates, Inc. | De-immunized shiga toxin a subunit effector polypeptides for applications in mammals |
| SI3604333T1 (sl) | 2014-03-11 | 2021-08-31 | Molecular Templates, Inc. | Proteini, ki obsegajo aminoterminalne proksimalne Shiga toksin podenota A efektorske regije in celico-ciljajoče vezavne regije imunogobulinskega tipa, ki so sposobne specifične vezave CD38 |
| ES2723774T3 (es) | 2014-03-11 | 2019-09-02 | Molecular Templates Inc | Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal |
| EP3137488B1 (en) | 2014-06-11 | 2019-01-02 | Molecular Templates, Inc. | Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same |
| KR20170074243A (ko) | 2014-10-31 | 2017-06-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 변형된 t 세포의 생성 방법 및 조성물 |
| KR20240110106A (ko) * | 2015-01-12 | 2024-07-12 | 애피바디 에이비 | Il-17a-결합 폴리펩티드 |
| KR20180030085A (ko) | 2015-07-26 | 2018-03-21 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| US10521754B2 (en) * | 2016-03-08 | 2019-12-31 | Auctane, LLC | Concatenated shipping documentation processing spawning intelligent generation subprocesses |
| CN111925425B (zh) * | 2020-08-12 | 2023-03-10 | 天津科技大学 | 甲胎蛋白特异性结合多肽及应用 |
| JP2025507294A (ja) | 2022-02-04 | 2025-03-18 | ザイトックス セラピューティクス アクチボラゲット | Ｅｇｆｒ結合ドメインとマスキングドメインとを含む融合タンパク質 |
| KR20250047787A (ko) | 2022-08-10 | 2025-04-04 | 교와 가부시키가이샤 | 어피바디 미셀 약물 복합체 |
| CN117106035B (zh) * | 2023-10-25 | 2024-04-23 | 烟台药物研究所 | 一种肿瘤靶向多肽、多肽偶联药物及制备与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| SE9901379D0 (sv) * | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
| GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| SE0301936D0 (sv) | 2003-06-30 | 2003-06-30 | Affibody Ab | New polypeptide |
| CA2531238C (en) * | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
| SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| EP1731523A4 (en) * | 2004-04-01 | 2009-08-12 | Takeda Pharmaceutical | THIAZOLOPYRIMIDINDERIVAT |
| DE05733048T1 (de) | 2004-04-06 | 2007-05-10 | Affibody Ab | Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung |
| US20070172901A1 (en) | 2004-04-16 | 2007-07-26 | Hidetoshi Okabe | Method for the evaluation of the functional status of the growth factor receptor protein expressed in malignant tumors |
-
2005
- 2005-12-05 GB GBGB0524788.7A patent/GB0524788D0/en not_active Ceased
-
2006
- 2006-12-05 CA CA2631430A patent/CA2631430C/en active Active
- 2006-12-05 CN CNA2006800523510A patent/CN101336250A/zh active Pending
- 2006-12-05 DK DK11194071.4T patent/DK2431383T3/en active
- 2006-12-05 EP EP11194071.4A patent/EP2431383B1/en active Active
- 2006-12-05 JP JP2008543714A patent/JP5898826B2/ja not_active Expired - Fee Related
- 2006-12-05 CN CN201310114471.0A patent/CN103288935B/zh not_active Expired - Fee Related
- 2006-12-05 WO PCT/EP2006/011669 patent/WO2007065635A1/en not_active Ceased
- 2006-12-05 US US12/085,576 patent/US8247375B2/en active Active
- 2006-12-05 ES ES11194071.4T patent/ES2599996T3/es active Active
- 2006-12-05 EP EP06829313.3A patent/EP1973934B1/en active Active
-
2012
- 2012-07-16 US US13/549,588 patent/US8598113B2/en active Active
-
2013
- 2013-10-16 US US14/055,443 patent/US9107965B2/en active Active
- 2013-12-27 JP JP2013270874A patent/JP2014087361A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101336250A (zh) | 2008-12-31 |
| US20140178301A1 (en) | 2014-06-26 |
| US8598113B2 (en) | 2013-12-03 |
| CA2631430C (en) | 2017-03-07 |
| EP2431383B1 (en) | 2016-09-28 |
| WO2007065635A1 (en) | 2007-06-14 |
| JP5898826B2 (ja) | 2016-04-06 |
| GB0524788D0 (en) | 2006-01-11 |
| EP2431383A1 (en) | 2012-03-21 |
| JP2014087361A (ja) | 2014-05-15 |
| CA2631430A1 (en) | 2007-06-14 |
| JP2009519013A (ja) | 2009-05-14 |
| CN103288935B (zh) | 2017-11-17 |
| EP1973934B1 (en) | 2014-11-05 |
| US9107965B2 (en) | 2015-08-18 |
| DK2431383T3 (en) | 2017-01-09 |
| US20090016957A1 (en) | 2009-01-15 |
| US20130005653A1 (en) | 2013-01-03 |
| EP1973934A1 (en) | 2008-10-01 |
| US8247375B2 (en) | 2012-08-21 |
| CN103288935A (zh) | 2013-09-11 |
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