ES2599728T3 - Derivados de isoxazolina usados en el control de ectoparásitos - Google Patents
Derivados de isoxazolina usados en el control de ectoparásitos Download PDFInfo
- Publication number
- ES2599728T3 ES2599728T3 ES12795228.1T ES12795228T ES2599728T3 ES 2599728 T3 ES2599728 T3 ES 2599728T3 ES 12795228 T ES12795228 T ES 12795228T ES 2599728 T3 ES2599728 T3 ES 2599728T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- substitutions
- hydrogen
- ectoparasites
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 244000078703 ectoparasite Species 0.000 title 1
- 150000002547 isoxazolines Chemical class 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 238000006467 substitution reaction Methods 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Un compuesto que tiene una estructura de fórmula I o II:**Fórmula** en la que A es donde * está unido al carbonilo; Y es hidrógeno, flúor, cloro o bromo; R1 es fenilo sustituido 2-4 veces, comprendiendo dichas sustituciones i) 1-4 sustituciones con el mismo o diferente de halo y 0-1 sustituciones con grupos metilo, difluorometilo, trifluorometilo, metoxi, trifluorometoxi o trifluoroetoxi o ii) 2 trifluorometilo; R2 es metilo, fluorometilo, trifluorometilo o perfluoroetilo; R3a y R3b se seleccionan independientemente de: hidrógeno, metilo, etilo, fluorometilo o R3a y R3b junto con el carbono al que están unidos forman un anillo de ciclopentilo o un anillo de ciclohexilo; Z es -CH2-, -CH2-CH2-, -CH(CH3)- o -C(CH3)2- y R6 es hidrógeno o metilo o una sal del mismo.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562383P | 2011-11-21 | 2011-11-21 | |
| US201161562428P | 2011-11-21 | 2011-11-21 | |
| US201161562428P | 2011-11-21 | ||
| US201161562383P | 2011-11-21 | ||
| PCT/US2012/065397 WO2013078071A1 (en) | 2011-11-21 | 2012-11-16 | Isoxazoline derivatives used in the control of ectoparasites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2599728T3 true ES2599728T3 (es) | 2017-02-02 |
Family
ID=47279084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12795228.1T Active ES2599728T3 (es) | 2011-11-21 | 2012-11-16 | Derivados de isoxazolina usados en el control de ectoparásitos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8546357B2 (es) |
| EP (1) | EP2782449B1 (es) |
| JP (1) | JP6118812B2 (es) |
| CN (2) | CN104066330B (es) |
| AR (1) | AR088669A1 (es) |
| AU (2) | AU2012327171B2 (es) |
| CA (1) | CA2891530A1 (es) |
| DK (1) | DK2782449T3 (es) |
| ES (1) | ES2599728T3 (es) |
| HK (1) | HK1202774A1 (es) |
| TW (1) | TW201333022A (es) |
| WO (1) | WO2013078071A1 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006214247C1 (en) * | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| US8716478B2 (en) | 2010-01-27 | 2014-05-06 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| PT2950644T (pt) | 2013-01-30 | 2017-08-16 | Agrofresh Inc | Utilização de benzoxaboróis como agentes antimicrobianos voláteis em carnes, plantas ou partes de planta |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| WO2014121124A1 (en) | 2013-02-01 | 2014-08-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| CA2917815C (en) | 2013-07-29 | 2022-08-30 | Attillaps Holdings | Organophosphates for treating afflictions of the skin |
| US11446241B2 (en) | 2013-07-29 | 2022-09-20 | Attillaps Holdings Inc. | Treatment of ophthalmological conditions with acetylcholinesterase inhibitors |
| ES2925021T3 (es) | 2014-06-19 | 2022-10-13 | Attillaps Holdings | Inhibidores de la acetilcolinesterasa para el tratamiento de afecciones dermatológicas |
| RU2595831C2 (ru) * | 2014-11-06 | 2016-08-27 | Федеральное государственное бюджетное научное учреждение Якутский научно-исследовательский институт сельского хозяйства | Способ защиты домашних северных оленей от нападения гнуса |
| SG10201912724SA (en) * | 2015-04-08 | 2020-02-27 | Boehringer Ingelheim Animal Health Usa Inc | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| CA3015662A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| PE20190119A1 (es) | 2016-05-12 | 2019-01-17 | Anacor Pharmaceuticals Inc | Esteres de oxaborol y sus usos |
| US11214655B2 (en) * | 2016-08-03 | 2022-01-04 | Galderma Research & Development | Method of crosslinking glycosaminoglycans |
| BR112019002290A2 (pt) * | 2016-08-03 | 2019-06-18 | Centre Nat Rech Scient | um novo hidrogel feito de glicosaminoglicanos reticulados duplos, particularmente ácido hialurônico reticulado, condroitina ou sulfato de condroitina, com ligações reversíveis usando ácido borônico ou derivados de boroxol levando a novos benefícios. glicosaminoglicanos reticulados duplos, uma ligação por meio de duas uniões de éter com um grupo hidroxila de cada dos dois glicosaminoglicanos e outra ligação por meio de um ânion de éster alcoxiboronato formado entre um hemiéster de boronato enxertado a um dos glicosaminoglicanos e uma função diol de ao outro glicosaminoglicano. a função diol pode ser uma função diol de cadeia principal ou uma porção diol de uma fração funcional diol enxertada ao outro glicosaminoglicano. |
| CN110023340A (zh) * | 2016-08-03 | 2019-07-16 | 高德美研究及发展公司 | 使糖胺聚糖交联的方法 |
| EP3609504A4 (en) | 2017-03-01 | 2021-03-03 | Anacor Pharmaceuticals, Inc. | NEW OXABOROLE ANALOGUES AND USES OF THE LATEST |
| CN112770742A (zh) | 2018-07-27 | 2021-05-07 | 阿佩塔生物科学有限公司 | 用于治疗蠕形螨引起的眼部和面部疾病的多杀菌素制剂 |
| CN109879826B (zh) * | 2019-03-18 | 2021-04-13 | 丽珠集团新北江制药股份有限公司 | 一种异噁唑啉类杀虫剂的制备方法 |
| CN110028462B (zh) * | 2019-04-12 | 2021-03-23 | 丽珠集团新北江制药股份有限公司 | 一种制备异噁唑啉类中间体及异噁唑啉的方法 |
| CN110684000B (zh) * | 2019-10-18 | 2021-08-31 | 上海皓元医药股份有限公司 | 苯并呋喃衍生物的制备方法 |
| US20210188789A1 (en) | 2019-12-18 | 2021-06-24 | Elanco Tiergesundheit Ag | Isoxazoline derivatives |
| CN111909143B (zh) * | 2020-07-30 | 2021-10-29 | 山东省联合农药工业有限公司 | 一种异噁唑啉取代的苯甲酰胺类衍生物及其制备方法与用途 |
| EP4204012A1 (en) | 2020-08-31 | 2023-07-05 | Pfizer Inc. | Methods of protecting rna |
| CN112552252B (zh) * | 2020-09-30 | 2024-01-02 | 浙江美诺华药物化学有限公司 | 一种氟雷拉纳中间体的制备方法 |
| WO2022192623A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling flea infestations in a canine |
| EP4304571A1 (en) * | 2021-03-11 | 2024-01-17 | In the Bowl Animal Health, Inc. | Oral canine feed and methods for controlling flea infestations in a canine |
| WO2022192631A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling tick infestations in a canine |
| BR112023026359A2 (pt) | 2021-06-16 | 2024-03-05 | Bayer Animal Health Gmbh | Pesticidas de (ti)oxazolina |
| EP4355735A1 (en) | 2021-06-16 | 2024-04-24 | Elanco Tiergesundheit AG | Isoxazoline pesticides |
| CN113735681B (zh) * | 2021-10-11 | 2023-12-12 | 丽珠集团新北江制药股份有限公司 | 一种氟雷拉纳中间体及其制备氟雷拉纳的方法 |
| WO2023118434A1 (en) * | 2021-12-22 | 2023-06-29 | Globachem Nv | Pesticidally active amide compounds |
| CN116102511A (zh) * | 2023-02-10 | 2023-05-12 | 河北圣雪大成制药有限责任公司 | 一种高纯度氟雷拉纳中间体的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1731512T3 (pl) * | 2004-03-05 | 2015-03-31 | Nissan Chemical Ind Ltd | Związek benzamidowy podstawiony izoksazoliną i środek do kontroli szkodliwych organizmów |
| AU2006214247C1 (en) | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
| CN101351450A (zh) * | 2005-12-15 | 2009-01-21 | 学校法人中央大学 | 金属配位化合物以及应用该化合物的有机电致发光元件 |
| TWI412322B (zh) * | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| EP1976536A4 (en) * | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| RS54108B1 (en) | 2006-02-16 | 2015-12-31 | Anacor Pharmaceuticals Inc. | SMALL MOLECULES CONTAINING BORON AS AGENTS FOR INFLAMMATION |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| TWI556741B (zh) * | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| US9493489B2 (en) * | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| WO2011019618A1 (en) * | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
-
2012
- 2012-11-06 AR ARP120104167A patent/AR088669A1/es unknown
- 2012-11-09 TW TW101141930A patent/TW201333022A/zh unknown
- 2012-11-16 JP JP2014543503A patent/JP6118812B2/ja active Active
- 2012-11-16 DK DK12795228.1T patent/DK2782449T3/en active
- 2012-11-16 US US13/678,578 patent/US8546357B2/en not_active Expired - Fee Related
- 2012-11-16 WO PCT/US2012/065397 patent/WO2013078071A1/en active Application Filing
- 2012-11-16 ES ES12795228.1T patent/ES2599728T3/es active Active
- 2012-11-16 CA CA2891530A patent/CA2891530A1/en not_active Abandoned
- 2012-11-16 AU AU2012327171A patent/AU2012327171B2/en not_active Ceased
- 2012-11-16 CN CN201280066186.XA patent/CN104066330B/zh not_active Expired - Fee Related
- 2012-11-16 EP EP12795228.1A patent/EP2782449B1/en not_active Not-in-force
- 2012-11-16 CN CN201610243119.0A patent/CN105906655A/zh active Pending
-
2015
- 2015-04-01 HK HK15103302.0A patent/HK1202774A1/xx not_active IP Right Cessation
-
2016
- 2016-06-22 AU AU2016204248A patent/AU2016204248A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014534260A (ja) | 2014-12-18 |
| AU2016204248A1 (en) | 2016-07-14 |
| HK1202774A1 (en) | 2015-10-09 |
| CN104066330B (zh) | 2016-05-18 |
| EP2782449B1 (en) | 2016-08-03 |
| TW201333022A (zh) | 2013-08-16 |
| US20130131017A1 (en) | 2013-05-23 |
| AU2012327171A1 (en) | 2013-06-06 |
| JP6118812B2 (ja) | 2017-04-19 |
| AR088669A1 (es) | 2014-06-25 |
| WO2013078071A1 (en) | 2013-05-30 |
| DK2782449T3 (en) | 2016-11-14 |
| EP2782449A1 (en) | 2014-10-01 |
| CN104066330A (zh) | 2014-09-24 |
| CN105906655A (zh) | 2016-08-31 |
| CA2891530A1 (en) | 2013-05-30 |
| AU2012327171B2 (en) | 2016-03-31 |
| US8546357B2 (en) | 2013-10-01 |
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