ES2587136T3 - Lactobacilos con acción antioxidante - Google Patents

Lactobacilos con acción antioxidante Download PDF

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Publication number
ES2587136T3
ES2587136T3 ES10703681.6T ES10703681T ES2587136T3 ES 2587136 T3 ES2587136 T3 ES 2587136T3 ES 10703681 T ES10703681 T ES 10703681T ES 2587136 T3 ES2587136 T3 ES 2587136T3
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Spain
Prior art keywords
casei
rhamnosus
termophilus
lactobacilli
delbrueckii
Prior art date
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ES10703681.6T
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English (en)
Inventor
Gianfranco Grompone
Marie-Christine Degivry
Sophie Legrain-Raspaud
Isabelle Chambaud
Raphaëlle BOURDET-SICARD
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Gervais Danone SA
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Gervais Danone SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/245—Lactobacillus casei

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Fodder In General (AREA)

Abstract

Cepa de Lactobacillus rhamnosus depositada en la CNMC con el número CNMC I-4271.

Description

imagen1
imagen2
imagen3
Tabla 1: Efecto de las bacterias acidolácticas alimentadas sobre la duración de vida de C. elegans.
Cepa -Especie
% de viabilidad
S2A – S. termophilus
95,7
S1B – S. termophilus
98,0
S2B – S. termophilus
94,1
S1C – S. termophilus
94,5
S1D – S. termophilus
98,2
S1E – S. termophilus
100,0
S1F – S. termophilus
95,
S1G – S. termophilus
98,2
S1H – S. termophilus
97,1
L2A – L. acidophilus
91,9
L5A – L. casei
100
L6A – L. delbrueckii
94,1
L8A – L. johnsoni
96,0
L9A – L. plantarum
91,75
OP50
89,5
Esto está según el hallazgo de Ikeda et al. (2007, citado anteriormente).
Supervivencia bajo estrés oxidativo
5 Se ensayó el efecto de 99 cepas de bacterias acidolácticas sobre la supervivencia en estrés oxidativo con H2O2 2, 3 y 5 mM. En la presencia de H2O2 5 mM, la viabilidad en la presencia de E. coli OP50 fue de aproximadamente el 93 % en comparación con la ausencia de estrés. Esto es indicativo de un 93 % de protección frente al estrés oxidativo. La siguiente Tabla 2 muestra el efecto de las bacterias acidolácticas seleccionadas sobre la protección frente al estrés oxidativo, mostrándose el efecto protector ejercido por la E. coli OP50 del control al 100 % como
10 nivel de referencia.
Tabla 2: nivel de protección frente a un estrés oxidativo producido por H2O2 5 mM, conferido por bacterias acidolácticas en comparación con E. coli OP50
Cepa -Especie
% de nivel de protección
E. coli OP50
100
Lactobacilos
L8F L. plantarum (299v)
14,6
L9F L. rhamnosus (LGG)
21,6
L10F L. rhamnosus
9,7
L1G L. acidophilus
102,5
L3G L. casei
7
L4G – L. casei
30
L6G – L. fermentum
23
5
Cepa -Especie
% de nivel de protección
L7G – L. helveticus
95
L8G – L plantarum
18
L9G – L rhamnosus (HN001)
81
L10G – L. rhamnosus
77
L1H – L. amylovorus
70
L4H – L. casei
87
L5H – L. delbrueckii
6
L7H – L. johnsoni
3
L8H – L. plantarum
9
L10H – L. rhamnosus
8
L8B – L. jonhsoni
76,8
L9A – L. plantarum
18,7
L9B – L. plantarum
13,3
L10B – L. rhamnosus
5,2
L11B – L. rhamnosus
70,9
L2C – L. delbrueckii
15,7
L4C – L. brevis
12,8
L6C – L. delbrueckii
0,0
L8C – L. johnsoni
59,3
L10C – L. rhamnosus
105
L11C – L. rhamnosus
96,3
L4D – L. casei
7,5
L6B – L. delbrueckii
21,2
L8B – L. johnsoni
82,2
L5C – L. casei
4,1
L7C-Lactobacillus sp.
5,7
L2D – L. bulgaricus
0,0
L5D – L. casei
0,0
L2E – L. bulgaricus
0,0
L3F – L. casei
0,0
L4F – L. casei
85,1
L6F – L. fermentum
0,0
L7F – L. helveticus
11,0
L11A – L. rhamnosus
102
6
Cepa -Especie
% de nivel de protección
L4B – L. casei
109
L3B – L. bulgaricus
80,1
L6A – L. delbrueckii
26,3
L2A – L. acidophilus
100
L2B – L. brevis
16,0
L5A – L. casei
9,8
L7B – L. fermentum
0,0
L5B – L. casei
89,6
L8A – L. johnsoni
111
L8D – L. johnsoni
87,1
L9D – L. reuteri
91,6
L10D – L. rhamnosus
94,1
L11D – L. rhamnosus
100
L3E – L. casei
104
L4E – L. casei
59,4
L5E – L. delbrueckii
34,2
L6E – L. fermentum
56,7
L8E – L. pentosus
54,2
L9E – L. gasseri
58,1
L10E – L. rhamnosus
88,6
L1F – Lactobacillus sp.
87,5
L2F – L. bulgaricus
52,2
L3A – Lactobacillus sp.
3
L1B – L. acidophilus
1
Bifidobacterias
B1B – B. animalis
35,8
B1C – B. animalis
26,2
B1D – B. animalis
7,4
B1E – B. animalis
0,0
B1G – B. bifidum
9,0
B2G – B. longum
5,9
Estreptococos
7
imagen4
imagen5

Claims (1)

  1. imagen1
ES10703681.6T 2010-01-08 2010-01-08 Lactobacilos con acción antioxidante Active ES2587136T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2010/000194 WO2011083354A1 (en) 2010-01-08 2010-01-08 Lactobacilli with anti-oxidant action

Publications (1)

Publication Number Publication Date
ES2587136T3 true ES2587136T3 (es) 2016-10-20

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US (1) US9056123B2 (es)
EP (1) EP2521769B1 (es)
CN (1) CN102858948B (es)
BR (1) BR112012016894A2 (es)
EA (1) EA024911B1 (es)
ES (1) ES2587136T3 (es)
PL (1) PL2521769T3 (es)
WO (1) WO2011083354A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102618456B (zh) * 2012-02-28 2013-08-21 江南大学 一种能够缓解慢性酒精性肝损伤的鼠李糖乳杆菌及其用途
EP2863929B1 (en) 2012-06-22 2016-07-20 Nestec S.A. Probiotic and polyphenol against neurodegeneration
JP2016507216A (ja) * 2012-11-12 2016-03-10 コンパニ・ジェルベ・ダノンＣｏｍｐａｇｎｉｅ Ｇｅｒｖａｉｓ Ｄａｎｏｎｅ 体脂肪の蓄積を低減させるためのラクトバチルスラムノサス株
EP2917335B1 (en) * 2012-11-12 2018-04-04 Compagnie Gervais Danone Use of lactobacillus rhamnosus strain for reducing weight gain and/or insulin resistance
US20160279180A1 (en) * 2013-08-23 2016-09-29 Consejo Superior de Investigaciones Científicas ( CSIC) Probiotic Strain of Lactobacillus Reuteri Exhibiting Anti-Helicobacter Activity, a Probiotic or Biotherapeutic Product Comprising Said Strain, and the Use Thereof
WO2015159125A1 (en) * 2014-04-15 2015-10-22 Compagnie Gervais Danone Use of lactobacillus rhamnosus for promoting recovery of the intestinal microbiota diversity after antibiotic dysbiosis
US9468659B2 (en) * 2014-11-06 2016-10-18 NWO Stem Cure, LLC Nutraceutical supplement with Lactobacillus rhamnosus
RU2617946C1 (ru) * 2015-11-24 2017-04-28 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Штаммы Lactobacillus brevis и Lactobacillus rhamnosus с установленной последовательностью генома, синтезирующие глутатион и комплекс внутриклеточных антиоксидантов
RU2705250C2 (ru) * 2018-02-05 2019-11-06 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Штамм Lactobacillus fermentum U-21, продуцирующий комплекс биологически активных веществ, осуществляющих нейтрализацию супероксид-аниона, индуцируемого химическими агентами
CN108410761B (zh) * 2018-03-06 2020-03-20 山东凤凰生物有限公司 一株具有降亚硝酸盐、抗氧化的鼠李糖乳杆菌及筛选分离方法
US20220241357A1 (en) * 2019-06-14 2022-08-04 Compagnie Gervais Danone Composition for amelioration of anxiety and/or stress

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Publication number Priority date Publication date Assignee Title
EP0649603B1 (en) 1993-05-11 2000-10-25 Otsuka Pharmaceutical Co., Ltd. Antioxidant food, antioxidant preparation and antioxidization method
WO1996020607A1 (fr) 1995-01-02 1996-07-11 Compagnie Gervais Danone Ferment lactique, et son utilisation pour la preparation de produits anti-diarrheiques
SE510753C2 (sv) * 1997-08-05 1999-06-21 Probi Ab Användning av en stam av Lactobacillus för tillverkning av ett läkemedel för reduktion av fibrinogenhalten i blod
PL347029A1 (en) 1998-10-01 2002-03-11 Probi Ab Reduction of oxidative stress factors
SE523771C2 (sv) * 1999-05-21 2004-05-18 Probi Ab Sportdryck innehållande mikronäringsämnen i kombination med levande laktobaciller
FR2809312B1 (fr) * 2000-05-25 2002-07-12 Gervais Danone Sa Utilisation de l. casei dans des compositions immunostimulantes
EE04580B1 (et) 2001-06-29 2006-02-15 Tartu �likool Mikroorganismi tüvi Lactobacillus fermentum ME-3 kui antimikroobne ja antioksüdantne probiootikum
GB0319503D0 (en) * 2003-08-19 2003-09-17 Danisco Process
FR2876029B1 (fr) * 2004-10-04 2008-11-14 Oreal Composition cosmetique et/ou dermatologique pour peaux sensibles.
US20100310713A1 (en) * 2007-09-21 2010-12-09 Kerry Group Services International Limited Probiotic composition
FR2928935B1 (fr) * 2008-03-19 2011-05-20 Gervais Danone Sa Souche de lactobacillus rhamnosus.

Also Published As

Publication number Publication date
US20130171117A1 (en) 2013-07-04
US9056123B2 (en) 2015-06-16
EP2521769A1 (en) 2012-11-14
BR112012016894A2 (pt) 2015-09-15
EA024911B1 (ru) 2016-11-30
CN102858948A (zh) 2013-01-02
PL2521769T3 (pl) 2017-01-31
CN102858948B (zh) 2015-11-25
WO2011083354A1 (en) 2011-07-14
EP2521769B1 (en) 2016-05-18
EA201290623A1 (ru) 2013-01-30

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